CLINICAL PHARMACOLOGY AND TOXICOLOGY
Εξάμηνο 5th ()
Ώρες Διδασκαλίας Teaching 0 hours, Laboratory 2 hours, Tutorial 0 hours , Clinical Training 0 hours (per week)
Δ.Ε.Π.
Γενική Περιγραφή
The purpose of this course is to study the way in which the genotype determines the response to drugs, how drugs alter gene expression and also how they can be used for individualization of drug therapy and innovative product development.
More specific topics are:
- Phenotype, genotype, haplotype
- Genetic polymorphisms
- Frequency of alleles - Law of Hardy & Weinberg
- Genetic polymorphisms and pharmacological response
- Studies of genotype / phenotype correlation
- Whole genome strategies
- Candidate gene approaches
- SNPs mapping as a base for the study of correlation and as a tool for individualizing therapy
- Toxicogenomics
- Implications of pharmacogenomics to the development of new drugs