Τμ. Ιατρικής Πανεπιστημίου Πατρών

GEORGOPOULOS NEOKLIS, Professor

Sector: Division of Internal Medicine Ι

Clinic/Laboratory: Department of Internal Medicine

Knowledge Subject:

Research Area: hypogonadotropic hypogonadism, hypothalamic amenorrhea, PCOS

Department of Internal medicine I, Division of Reproductive Endocrinology, Patras Medical School, University Hospital, Rio 20500

+302610329876 neoklisgeorgo@gmail.com

Office hours

Download Curriculum Vitae

Summary of Curriculum Vitae

Name: Georgopoulos Neoklis

Degree: Assistant Professor in Reproductive Endocrinology

Date of birth: 9.12.58

Place of birth: Patras-Greece

Family status: Married. Two children ( girls)

Address: Benizelou Roufou 63, Patras 26222-Greece

Medical school: Bucarest School of Medicine -Romania1977-1983 Gratuated 12.9.1983.

M.D. : Diplomat of the Greek Board of Endocrinology 21.4.1994.

Doctorate: “Hormonal response to stress and the characteristics of personality in adolescents with IDDM” Univ. of Athens–Greece. 23.1.1995.

Postgratuate courses:

• 43rd Postgraduate course in Endocrinology The Endocrine Society San Diego, California (USA) 9-13.10.1991

• European Society for Paediatric Endocrinology Summer School 1993 Monterey, California (USA) 30.5- 3.6.1993

• Postgraduate course on Growth Hormone and Growth factors Stokholm, Sweden 2-6.5.1994 Scholarship: Scholar under the authority of the Fulbright-Hays Act (P.L 256, the 87th Congress) at the Reproductive Unit of the Massachusetts General Hospital and the Harvard Medical School 1.9.94–31.12.95

Training:

• Resident in Internal Medicine, Department of Medicine, University of Patras Medical School under the direction of Professor A.G. Vagenakis 1.8.84–10.9.85.

• Resident in Internal Medicine, Department of Medicine, Hospital of God’s Providence “Pammakaristos” Athens 10.7.87–9.7.89.

• Clinical Fellow in Paediatric Endocrinology, Department of Paediatrics, Endocrine Unit “Ag. Sophia” Childrens Hospital, University of Athens Medical School, under the direction of Prof. A. Dacou-Voutetakis 3.8.89–13.8.91.

• Research Fellow in Paediatric Endocrinology, (6 months) Department of Paediatrics, Endocrine Unit, University of Athens Medical School, under the direction of Prof. A. Dacou-Voutetakis 13.8.91–11.2.92.

• Fellow in Adult Endocrinology, Department of Internal Medicine, Division of Endocrinology, University of Patras Medical School, under the direction of Prof. A. Vagenakis. 17.2.92–16.2.94.

• Research Fellow in Reproductive Endocrinology, Reproductive Unit of the Massachusetts General Hospital and the Harvard Medical School Boston, USA, Under the direction of Prof. W. Crowley 1.9.94–18.9.96.

• Research Fellow in Endocrinology Department of Internal Medicine, Division of Endocrinology, University of Patras Medical School under the direction of Prof. A. Vagenakis. 30.9.96–30.9.97.

• Register in Endocrinology Department of Internal Medicine, Division of Endocrinology, University of Patras Medical School under the direction of Prof. A. G. Vagenakis. 1.10.97 – 21.5.2001.

• Lecturer in Reproductive Endocrinology Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Patras Medical School under the direction of Prof. V. A. Tzingounis. 21.5.2001-1.9.2007.

• Assistant Professor in ReproductiveEndocrinology Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Patras Medical School under the direction of Prof. G. Decavalas 1.9.2007-2.2013.

• Associate Professor in Reproductive Endocrinology Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Patras Medical School under the direction of Prof. G. Decavalas 2.2013-7.2017.

• Professor in Reproductive Endocrinology, University of Patras Medical School 7.2017-today.

Today Field of interest in research: Reproductive Endocrinology, Growth.

Speaking languages:

Greek, English, French, Romanian

Undergraduate Courses

Postgraduate Courses

Postgratute course in Basic Medical Science of Patras Medical Scool. Clinical examples of stimulatory and inhibitory mutations;genotype, phenotype correlations. 2001 until today.

Postgratute course in Reproductive Endocrinology of Athens University of Medicine. Evaluation of amenorrhea. 2001 until today of Patras Medical Scool.

Selected Publications

Nr. of publications: 80

Citation index: 1180

Self-refering: 70

h-index: 17.0

Cumulative Impact factor: 225.102 (80)

Mean Impact Factor:225.102/79=2.850

Georgopoulos N, Pralong F, Seidman C, J Seidman J, Crowley W,Vallejo M. Genetic heterogeneity evidenced by low incidence of KAL–1 gene mutations in sporadic cases of Gonadotropin Releasing Hormone (GnRH) deficiency. J. Clin. Endocrinol. Metab., 82: 213–217 (1997). Impact Factor: 5,641. Citation Index: 102

Georgopoulos N, Markou K, Theodoropoulou A, Paraskevopoulou P, Varaki L, Kazantzi Z, Leglise M, Vagenakis AG. Growth and pubertal development in elite female rhythmic gymnasts. J Clin Endocrinol. Metab. 84: 4525-4530, (1999). Impact Factor: 5,641. Citation Index: 98

Markou K, Georgopoulos N, Kyriazopoulou V, and Vagenakis AG. Iodine-Induced Hypothyroidism. Thyroid 11(5): 501-510 (2001). Impact Factor: 2,219. Citation Index: 181

Georgopoulos NA, Markou K.B, Theodoropoulou A, Vagenakis GA, Benardot D, Leglise M, Dimopoulos J .., and Vagenakis A G. Height velocity and skeletal maturation in elite female rhythmic gymnasts. J Clin Endocrinol. Metab. 86:5159-5164 (2001). Impact Factor: 5,641. Citation Index: 58

Georgopoulos NA, Markou KB, Theodoropoulou ABenardot D, Leglise M, Vagenakis AG. Growth Retardation in Artistic Compared to Rhythmic Elite Female Gymnasts. J Clin Endocrinol. Metab. 87(7): 3169-3173 (2002). Impact Factor: 5,641. Citation Index: 43

Neoklis A. Georgopoulos, Gerasimos P. Sykiotis, Argyro Sgourou, Adamantia Papachatzopoulou, Kostas B. Markou, Venetsana Kyriazopoulou, Athanasios G. Papavassiliou and Apostolos G. Vagenakis. Autonomously Functioning Thyroid Nodules in a Former Iodine Deficient Area Commonly Harbor Gain-of-function Mutations in Thyrotropin’s Signaling Pathway. Eur J Endocrinol 149:287-292 (2003). Impact Factor: 2,131 Citation Index: 19

Georgopoulos NA, Theodoropoulou A, Leglise M, Vagenakis AG Markou KB. Growth and Skeletal Maturation in Male and Female Artistic Gymnasts. J Clin Endocrinol. Metab. 89: 4377-4382 (2004). Impact Factor: 5,641. Citation Index: 32

Markou KB, Mylonas P, Theodoropoulou A, Kontogiannis A, Leglise M, Vagenakis AG, Georgopoulos NA. The influence of intensive physical exercise on bone acquisition in adolescent elite male and female artistic gymnasts. J Clin Endocrinol. Metab. 89: 4383-4387 (2004). Impact Factor: 5,641. Citation Index: 42

Theodoropoulou A, Markou KB, Vagenakis GA, Benardot D, Leglise M, Kourounis G, Vagenakis AG, Georgopoulos NA. Delayed but normally progressed puberty is more pronounced in artistic Compared with rhythmic elite gymnasts due to the intensity of training. J Clin Endocrinol Metab. 90(11):6022-7 (2005). Impact Factor: 5,641. Citation Index: 23

Vagenakis GA, Sgourou A, Papachatzopoulou A, Kourounis G, Papavassiliou AG, Georgopoulos NA. The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. Fertil Steril. 84(6):1762-1765 (2005). Impact Factor: 3,344. Citation Index: 13

Georgopoulos NA, Koika V, Galli-Tsinopoulou A, Spiliotis BE, Adonakis G, Keramida MK, Sgourou A, Koufogiannis KD, Papachatzopoulou A, Papavassiliou AG, Kourounis G, Vagenakis GA. Renal dysgenesis and KAL1 gene defects in patients with sporadic Kallmann syndrome. Fertil Steril. 88(5):1311-1317, (2007). Impact Factor: 3,344. Citation Index: 14

Georgopoulos NA, Saltamavros AD, Vervita V, Karkoulias K, Adonakis G, Decavalas G, Kourounis G, Markou KB, Kyrazopoulou V. Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance. Fertil Steril. Jul;92(1):250-5 (2009). Impact Factor: 4,167. Citation Index: 15

Marioli DJ, Saltamavros AD, Vervita V, Koika V, Adonakis G, Decavalas G, Markou KB, Georgopoulos NA. Association of the 17-hydroxysteroid dehydrogenase type 5 gene polymorphism (-71A/G HSD17B5 SNP) with hyperandrogenemia in polycystic ovary syndrome (PCOS). Fertil Steril. Aug;92(2):648-52 (2009). Impact Factor: 4,167. Citation Index: 9

Koika V, Marioli DJ, Saltamavros AD, Vervita V, Koufogiannis KD, Adonakis G, Decavalas G, Georgopoulos NA. Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor 2 (PPARgamma2) with decreased Basic Metabolic Rate (BMR) in women with polycystic ovary syndrome (PCOS). Eur. J. Endocrinol. Aug;161(2):317-22 (2009). Impact Factor: 3,791. Citation Index: 13

Georgopoulos NA, Karagiannidou E, Koika V, Roupas ND, Armeni A, Marioli D, Papadakis E, Ck W, Panidis D. Increased frequency of the Anti-Mullerian-inhibiting hormone receptor 2 (AMHR2) 482 A>G polymorphism in women with Polycystic Ovary Syndrome (PCOS): Relationship to Luteinizing Hormone (LH) Levels. J Clin Endocrinol Metab. 2013 Aug 22. Impact factor: 6.500

Selected Presentations

107 Lectures from 2000 to 2013 Adolescent athletes Chair: Neoklis A. GEORGOPOULOS (Greece), Patrick FENICHEL (France) The adolescent athlete: present and future. 16th Word Congress of Pediatric and Adolescent Gynecology Montpellier, France, 22-25. 5. 2010 The influence of intensive physical training on growth and pubertal development. ESPE Paediatric and Adolescent Gynaecology Working Group. 50th ESPE annual Meeting 2011 Glascow, Scotland, 25.9.2011 Puberte et sport. L’adolescente, le sport et ses consequences. 25emes journees INFO-GYN Tarbes, France 30.9.2011 Thyroid function in menopause. 9th European Congress on Menopause and Andropause (EMAS) Athens 28-31.3.2012 The genetic component of erectile dyfunction. 1st Mediterranean Congress on Human Sexuality and Reproduction, Cypriot Symposium on the conflict of sexes and the conflict of Nations. Pafos, Cyprus, 22-23.11.2012 Intensice exercise and adolescence. 1st COMBO Endcorinology Course: The ovary. Monastery “Evagelistria: Viotia, Greece, 11-14.9.2013

PhD Theses Advisor

Member of PhD Committees that have been fulfilled

1. Liatsis Spyridon: “Evaluation of the placental hormone concentration in the neonatal cordon blood in newborns whose mothers smoked during pregnancy”

2. Margeli Theodora: “The function of the hypothalamic - pituitary-adrenal axis in hospitalized patients in the Medical Department due to various degrees of disease”

3. Vervita Vasiliki: “Study of plasma viscosity in women with polycystic ovary syndrome (PCOS) and its correlation with hormonal and metabolic parameters”

4. Saltamavros Alexandros: “Study of basal metabolic rate (BMR), insulin resistance as well as the polymorphisms of A2b and b3 adrenergic receptors genes, of PPAR gene and of HSD1 gene in women with polycystic ovary syndrome”

5. Gkogkos Panagiotis; “Assessment of AHP and beta-HCG serum levels during the second trimester of pregnancy as indices of prediction of adverse outcome”

6. Fotopoulos Andreas: “Follow up by vaginal ultrasound and endometrial scraping of women with breast cancer treated with tamoxifen and evaluation of the presence of polymorphisms in genes of the estrogen pathway”

7. Vagenakis George: “Detection of gene mutations in patients with GnRH deficiency (Kallmann Syndrome and Idiopathic Hypogonadotropic Hypogonadism”.

Supervisor of PhD thesis that have been fulfilled

1. Armeni Anastasia: “The genetic predisposition of female sexuality”.

2. Roupas Nikolaos: “The hormonal homeostasis of adipose tissue in intense physical exercise in male and female athletes”.

3. Karela Anastasia: “Determination of genetic, early vascular and hormonal markers of cardiovascular risk in young women with polycystic ovarian syndrome (PCOS)”.

4. Markantes George: “The influence of hormonal contraceptives in genetic, vascular, early biochemical and hormonal markers of high risk for cardiovascular disease in young women with polycystic ovarian syndrome (PCOS)”.

Other Activities

Reviewer in International Scientific Journals

1. Annals of Nutrition and Metabolism Impact factor: 1.970

2. Applied Physiology, Nutrition, and Metabolism. Impact factor: 2.424

3. Archieves of Medical Research Impact factor: 1.884

4. Asian Journal of Andrology Impact factor: 1.3205.

5. Behavioural Brain Research Impact factor: 2.473

6. Biological Psychiatry Impact factor: 5.505

7. Clinical Endocrinology Impact factor: 3.201

8. Clinical Pharmacology Therapeutics (CLIN PHARMACOL THER) Impact factor: 5.061

9. European Journal of Endocrinology Impact factor: 3.539

10. European Journal of Human Genetics Impact factor: 3.564

11. European Journal of Internal Medicine Impact factor: 1.385

12. European Journal of Obstetrics & Gynecology and Reproductive Biology Impact factor: 2.321

13. Fertility Sterility Impact factor: 3.344

14. Gene Impact factor: 2.266

15. Hormones (Athens) Impact factor: 2.100

16. Human Reproduction Impact factor: 3.856

17. Human Molecular Reproduction Impact factor: 3.344

18. International Journal of Medical Sciences (IJMS) Impact factor: 2.865

19. Journal of Cancer Research and Clinical Oncology Impact factor: 2.194

20. Journal of Cellular and Molecular Medicine Impact factor: 5.228

21. Journal of Neuroendocrinology Impact factor: 3.700

22. Journal of Physical activity and health Impact factor:

23. Journal of the Renin-Angiotensin-Aldosterone System. Impact factor: 1.600

24. Obesity Impact factor: 3.366

25. Metabolism Impact factor: 2.588

26. Molecular Medicine Impact factor: 5.020

27. Systems Biology in Reproductive Medicine. Impact factor: 0.800

28. Thyroid Impact factor: 2.219

MEMBER OF EDITORIAL BOARD

1. Anir (Men) Official Journal of the Greek Society of Andrology

2. Hormones (Athens) Official Journal of the Greek Endocrine Society

RECOGNITION OF SCIENTIFIC WORK:

AWARDS

1. C. Dakou–Voutetakis, K. Karavanaki–Karanassiou, V. Petrou, N. Georgopoulos, M. Maniati–Christidi “The growth pattern and final height in girls with Turner Syndrome treated with human growth hormone and in untreated Controls” Pediatrics, 101, 663–668, (1998). Award of D. Ikkou of Greek Endocrine Society as the best Greek publication in 1998. 27th Panellenic Congress of Endocrinology and Metabolism, Athens 2001

2. G Sykiotis, A. Sgourou, A. Papachatzopoulou, KB. Markou, V. Kyriazopoulou, AG. Papavassiliou AG Vagenakis, NA. Georgopoulos “Gain-of function mutations in the thyrotropin signaling pathway in autonomous thyroid nodules”. Award of S. Pitouli as the best announced work in Laboratory Investigation of the Greek Endocrine Society 28th Panellenic Congress of Endocrinology and Metabolism, Ioannina March 2002

3. Georgopoulos NA, Markou K, Theodoropoulou A,Vagenakis G.A, Benardot D, Leglise M, Dimopoulos J.C.A. and Vagenakis A.G. 2001. “Height velocity and skeletal maturation in elite female rhythmic gymnasts”. J Clin Endocrinol Metab 86:5159-5164. Award G. Kalaitzoglou of Greek Society of Gynecology, Child and Youth school-age. 28th National Congress of Child and Adolescent Gynecology, Ioannina March 2002

4. KB Markou, P Mulonas, A Theodoropoulou, NA Georgopoulos, A Kontogiannis, M Leglise and AG Vagenakis “Bone mineral density, skeletal maturation and puberty in high level athletes in gymnastics” Best of Congress Award “Alexandros Kalos” of the Greek Society for the Study of Bone Metabolism 11st National Congress of the Study of the Metabolism of Bones Athens April 2003

5. NA Georgopoulos, S Papapetropoulos. E Xroni, ES Papadeas, PA Dimopoulos, V Kyriazopoulou, M.B. Davis, L. Eunson, G Kourounis, VA Tziggounis “Cerebellar ataxia, hypergonadotrophic hypogonadism and familial sensorineural hearing loss” Best of Congress Award of Greek Society of Gynecology, Child and Youth. 9th National Congress of Obstetrics and Gynecology Alexandroupoli 2003

6. K Markou, AG Vagenakis, C Scopa, M makri, K Vagenas D Koukouras, NA Georgopoulos, A Theodoropoulou, I Chabaios, V.Koika.” The symporter Na/I in the thyroid and the mammary gland. Basic and biochemical study of its physiology and pathophysiology. Its role in the adaptive mechanisms of thyroid when treated with pharmacological doses of iodine” Award of Greek Endocrine Society 2006

7. L Rottstein , G Polykarpou, E Lampropoulou, A theodoropoulou, P Mulonas, G Oikonomou, A Tsekouras, P Giamalis, E Koukkou, AG Vagenakis, NA Georgopoulos, KB Markou. “Muscle mass and body mass index, a powerful growth factor in bone density of young athletes gymnastics high level racing” Best of Congress Award “Alexandros Kalos” of the Greek Society for the Study of the Metabolism of Bones 15th National Congress of the Study of the Metabolism of Bones Pafos, Cyprus, May 2007

8. NA Georgopoulos, Vasiliki Koika, Petros Varnavas, Dionusios Chrysis, Stefanos Mantagos. “Genetic diagnosis of Kallmann Syndrome during childhood” Award of S. Pitouli as the best announced work in Laboratory Investigation of the Greek Endocrine Society. 35th Panellenic Congress of Endocrinology and Metabolism, Athens March 2008

9. Award of Honor awarded by the University of Patras for the voluntary action in the treatment of Iodine deficiency in residents of the mountainous Caucasus region. Patras, April 2008

10. DK Panidis, AD Piouka, IK Katsikis, NA Georgopoulos “The Anti-mullerian hormone serum level are elevated in women with the 'classical' polycystic ovaries syndrome and are positively influenced by serum LH concentrations and negative by BMI” Honorary distinction as the best work of the Congress 2nd Panellenic Congress of Gynecological Endocrinology Athens 2009

11. Markou KB, Tsekouras A, Anastasiou E, Vlassopoulou B, Koukkou E, Vagenakis GA, Mylonas P, Vasilopoulos C, Theodoropoulou A, Rottstein L, Lampropoulou E, Apostolopoulos D, Jabarov R, Vagenakis AG, Georgopoulos NA. ”Treating Iodine Deficiency: Long-Term effects of iodine repletion on growth and Pubertal Development in school-age children”. Award of “Professor D. Koutra” as the best Greek publication in the field of Thyroid on 2008. 36th Panellenic Congress of Endocrinology and Metabolism, Alexandroupoli, April 2009

12. Vasiliki Koika, Xatzi Elisabeth, Dimitra Marioli, Koutsouni Anastasia, Ioannis Georgiou, NA Georgopoulos “ Functional analysis of the presence of a mutation in heterozygosis in the second intracellular loop of the GnRH receptor and its contribution in the pathogenesis of Idiopathic Hypogonadotropic Hypogonadism (IHH)” Award of S. Pitouli as the best announced work in Laboratory Investigation of the Greek Endocrine Society 36th Panellenic Congress of Endocrinology and Metabolism, Alexandroupoli April 2009

13. Vasiliki vervita, Anastasia Karela, George A Vagenakis, Vasiliki Koika, Dimitra Marioli, Neoklis A Georgopoulos “Determination of genetic, early vascular and hormonal markers of cardiovascular risk in young women with polycystic ovarian syndrome (PCOS)”. Sponsored 2009 by Procter and Gamble Hellas Ltd “Papanikolaou grant” 11th Panellenic Congress of Obstetrics and Gynecology, Athens, April 2009

14. NA Georgopoulos, AD Piouka, I Katsikis, AD Saltamavros, K Mpakatselou, G Decavalas, A Karnakaki, D Panidis “Correlation of the Anti-Mullerian hormone with the LH and FSH serum levels and with the obesity in young women with polycystic ovarian syndrome (PCOS)” Award of A Farmakioti as the best poster of the Congress, 37th Panellenic Congress of Endocrinology and Metabolism, Athens April 2010

Abstracts In International Scientific Meetings

68 Abstracts from 2001 to 2013

Abstracts In National Scientific Meetings

94 Abstracts from 2001 to 2013

Scientific Lectures

107 Lectures from 2000 to 2013

Round tables Presidencies in Scientific Meetings

Grants

1. Co-investigator in the Grant “Study of growth hormone (GH) release in beta-thalassemia adult patients. 1 year replacement treatment in patients with GH neurosecretory dysfunction and impaired GH secretion. Highlighting the necessity and beneficial effects of treatment with GH. Funded by the Ministry of Research and Technology and the Society Upjon-Hellas in 1997 Principal Investigator: T Alexandridis Research Team AG Vagenakis, M Spylioti: NAGeorgopoulos.

2. Co-investigator – Laboratory Leader in the Grant “Detection of mutations in the TSH receptor in toxic thyroid adenomas”, funded by C. Caratheodory Program of the Research Committee of the University of Patras Medical School, 1.10.1998. Realization of the project: 1998-2000. Principal Investigator: Κ. Markou Research team: NA Georgopoulos, AG Vagenakis, V Kyriazopoulou.

3. Co-investigator in the Grant "Program for emergency supplementation of Iodine in school-age population of the mountainous areas of the Republic of Azerbaijan." The aim of the project was the treatment with iodine of 250.000 children in regions of Azerbaijan with Iodine deficiency. It was funded by the European Union: 96 million drachmas, the Ministry of Foreign Affaires of the Hellenic Republic and the Greek Society of Endocrinology in 1999, under the auspices of the NGO "Doctors of the World-Greek Section" which had developed and implemented this program. Realization of the project: 10.1999-10.2000. Research team: AG Vagenakis, K Markou, NA Georgopoulos, E Anastasiou, V Vlassopoulou, N Lazarou, M Makri.

4. Co-coordinator in the Grant “Monitoring and supporting growth and pubertal development in Rhythmic and Artistic Gymnasts of the Greek National Team” funded by the Greek Federation of Gymnastics Research team: AG Vagenakis, NA Georgopoulos, K Markou.

5. Coordinator of the grant “Evaluation of the presence of mutations in the gene of GnRH, the receptor gene of GnRH and in the sequence of the promoter of these genes in patients with hypogonadotropic hypogonadism” funded by C. Caratheodory Program of the Research Committee of the University of Patras Medical School. Realization of the project: 2002-2005.

6. Co-investigator in the Grant "Treatment of iodine deficiency in school-age population of the mountainous Azerbaijan" funded by the Ministry of Foreign Affairs and the Ministry of Education. The aim of the project was the administration of iodine in 250000 children in mountainous regions of Azerbaijan Realization of the project: 2004-2005. Research team: AG Vagenakis, K Markou, NA Georgopoulos.

7. Design and implemention of a project for mutations detection in Kallmann syndrome, funded by the Greek Society of Endocrinology 2007. Project title: "Detection of gene mutations in FGFR 1, the gene for GPR54, the Prokineticin 2 gene and the Prokineticin receptor 2 in patients with GnRH deficiency (idiopathic hypogonadotropic hypogonadism and Kallmann syndrome) as well as detection of mutations in the gene KAL1 in patients with renal agenesis / dysgenesis Realization of the project: 2007-2008. Principal Investigator: NA Georgopoulos.

8. Co-investigator in the Grant "Inventory of iodine deficiency disorders (IDD) and the daily iodine intake in school-age populations of Uzbekistan" funded by the Agency for International Development Cooperation of the Ministry of Foreign Affairs and the Direction of International Relations in Education of the Ministry of Education of the Hellenic Republic. The aim of the project was detection and confrontation of IDD in Uzbekistan. Realization of the project: 2006-2007. Research team: AG Vagenakis, K Markou, NA Georgopoulos.

9. Co-investigator in the Grant "Recording the daily iodine intake and the iodine deficiency disorders (IDD) in school-age populations in the Republic of Georgia" participating in the design and implemention of this program funded by the Ministry of Education and Foreign Affair of the Hellenic Republic in 2008. The aim of the project was to administrate iodine in 1000 pregnant women in regions with iodine deficiency of the Republic of Georgia. Realization of the project: 2008-2010. Research team: AG Vagenakis, K Markou, NA Georgopoulos.

10. Co-investigator in the Grant "Contribution to the treatment of iodine deficiency disorders (IDD) of the school-age population in mountainous areas (Caucasus) of Azerbaijan" participating in the design and implemention of this program funded by the Ministry of Education and Foreign Affairs of the Hellenic Republic in 2004. The aim of the project was to follow the results of the previous administration of iodine in 250000 children in regions with iodine deficiency of mountainous regions of Azerbaijan and to transfer technology in Azerbaijani doctors by creating a fully equipped laboratory for the detection of IDD in the mountainous areas of Azerbaijan. Realization of the project: 2004-2005. Research team: AG Vagenakis, K Markou, NA Georgopoulos.

11. Coordinator of the grant “Evaluation of the presence of gene mutations in FGFR1, the gene for GPR54, the Prokineticin 2 gene, the Prokineticin receptor 2, and in the GnRH receptor in patients with GnRH deficiency (idiopathic hypogonadotropic hypogonadism and Kallmann syndrome). Evaluation, in vitro, of the functional effect of new described mutations in the GnRHR and in GPR54 receptor as well as detection of mutations in the gene KAL1 in patients with renal agenesis / dysgenesis” funded by C. Caratheodory Program of the Research Committee of the University of Patras Medical School, 2010 20 presidencies from 2002 to 2013 Congress Organizing Committee “Endorama” Congress of Endocrinology, from 2009 until nowadays in Patras, Greece.