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SPIRIDONIDIS ALEXANDROS, Professor

SPIRIDONIDIS ALEXANDROS

Sector: Division of Internal Medicine Ι

Clinic/Laboratory: Department of Internal Medicine

Knowledge Subject:

Research Area: Hematopoietic Stem Cells and Engineering (Ex vivo expansion, purging, plasticity) - Leukemia (Chemoresistance, Leukemic Stem Cells) - Hematopoietic Stem Cell Transplantation (Patogenesis of GvHD, Allo-Immunoregulation, adoptive cell therapy)

University Hospital of Patras, Hematology Division / BMT Unit, 5th Floor, 26500 Rio-Patras, Greece 5th Floor, BMT Unit

+30 2610 999247 +30 2610993950 spyridonidis@upatras.gr

Download Curriculum Vitae

Undergraduate Courses

Selected Publications

  1. A. Spyridonidis, M. Liga, E. Triantafyllou, M. Themeli, M. Karakantza, N. Zoumbos. Pharmacokinetics and clinical activity of very low dose alemtuzumab in transplantation for acute leukemia Bone Marrow Transplant (in press, 2010)
  2. Waterhouse M, Themeli M, Bertz H, Zoumbos N, Finke J, Spyridonidis A. Horizontal DNA transfer from donor to host cells as an alternative mechanism of epithelial chimerism after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. (in press, 2010).
  3. M Themeli, L Petrikkos, M Waterhouse, H Bertz, E Lagadinou, N Zoumbos, J Finke and A Spyridonidis. Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro study and implications to secondary neoplasia. Leukemia 24, 536-543, 2010
  4. E. Lagadinou, P. Ziros, O. Tsopra, K. Dimas, D. Kokkinou, E. Thanopoulou, M. Karakantza, P. Pantazis, A. Spyridonidis, N. Zoumbos. C-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myelod leukemia. Leukemia 10, 1899-908, 2008
  5. Marks R, Potthoff K, Hahn J, Ihorst G, Bertz H, Spyridonidis A, Holler E, Finke JM. Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies. Blood 112(2):415-25, 2008
  6. Faber P, Fisch P, Waterhouse M, Schmitt-Graff A, Bertz H, Finke J, Spyridonidis A. Frequent genomic alterations in epithelium measured by microsatellite instability following allogeneic hematopoietic cell transplantation in humans. Blood 5:107:3389-3396, 2006
  7. Metaxas Y, Zeiser R, Schmitt-Graeff A, Waterhouse M, Faber P, Follo M, BertzH, Finke J, Spyridonidis A. Human hematopoietic cell transplantation results in generation of donor-derived epithelial cells. Leukemia. 19(7):1287-9, 2005
  8. Spyridonidis A, Bertz H, Ihorst G, Grullich C, Finke J. Hematopoietic cell transplantation from unrelated donors as an effectivetherapy for older patients (> or = 60 years) with active myeloid malignancies. Blood. 105(10):4147-8, 2005
  9. Spyridonidis A, Dwenger A, Tomann T, Follo M, Behringer D, Finke J. Epithelial tissue chimerism after human hematopoietic cell transplantation is a real phenomenon. Am J Pathol 164:1147-1155, 2004
  10. Dwenger A, Rosenthal F, Machein M, Waller C, Spyridonidis A Transplanted bone marrow cells preferentially home to the vessels of in situ generated murine tumors rather than of normal organs. Stem cells 22: 86-92, 2004
  11. Spyridonidis A, Bernhardt W, Behringer D, Köhler G, Azemar A, Pflug A, Henschler R: Influence of culture conditions on the survival and proliferation of tumor cells during ex vivo culture of CD34+ progenitor cells. Blood 93:746-755, 1999
  12. Spyridonidis A, Schmidt M, Bernhardt W, Papadimitriou A, Azemar M, Wels W, Groner B, Henschler R: Purging of mammary carcinoma cells during ex vivo culture of CD34+ hematopoietic progenitors with recombinant immunotoxins. Blood 91:1820-1827, 1998

Selected Presentations

  1. Spyridonidis A. Tumor cell depletion during ex vivo expansion of haematopoietic stem cells. Ex vivo expansion of hematopoietic stem cells. 3rd Annual European Cancer Center (EuCC) Symposium Clinical and Experimental Oncology Strasbourg (invited speaker), June 1996
  2. Spyridonidis A. Purging of mammary carcinoma cells during CD34+ expansion culture. 6th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego April, (invited speaker) 1998
  3. Spyridonidis A. Ex vivo purging in breast cancer autografting. EBMT Solid Working Party. International Meeting on Hematopoietic Progenitor cells expanded ex vivo. Ravenna, Italy, (invited speaker) November, 1999
  4. Spyridonidis A. Ex vivo expansion as a purging procedure in autografts for breast cancer. IBMTR/ABMTR Tandem Meeting of the American Society of Bone Marrow Transplantation (ASBMT), California, USA, (invited speaker) 2000
  5. Spyridonidis A, Finke J. Epithelial chimerism after human HSCT is a real phenomenon not caused by fusion. 2nd International Symposium on the Clinical Use of Cellular Products, Regensburg, March, (invited speaker) 2003
  6. Spyridonidis A. Stem Cell Plasticity. Facts or Fiction? 5th International Symposium in "Molecular Hematology". Freiburg (invited speaker) 2004
  7. Spyridonidis A. Stem Cell Plasticity. Facts or Fiction? 1st Meeting from the Working Group of Stem Cell Research of the German Society for Hematology and Oncology, Heidelberg, (invited speaker) 2005
  8. Spyridonidis A. New insights in the development of biological chimeras after human hematopoietic cell transplantation. 1st International Conference 2008 of the Cyprus Society of Human Genetics (CSHG), Nicosia, Cyprus, (invited speaker) October 2008
  9. Spyridonidis A. Advances in stem cell transplantation, Deutsche Arbeitsgemeinschaft fur Knochenmark und Blutstamzelltransplantation, Germany (invited speaker) May 2009
  10. Spyridonidis A. Should we transplant old patients with acute myeloid leukemia? 2nd World Cancer Congress 2009, China (invited speaker) June 2009
  11. Spyridonidis A. Treatment of AML in elderly. Panhellenic Haematological Symposium, Athens, 2004 (invited speaker)
  12. Spyridonidis A. Mobilization of healthy donors with G-CSF. Panhellenic Haematological Symposium, Thessaloniki, 2007 (invited speaker)
  13. Spyridonidis A. Haploidentical hematopoietic stem cell transplantations. Panhellenic Haematological Symposium, Athens, 2008 (invited speaker)
  14. Spyridonidis A. GCP and GMP in Hematology. Panhellenic Haematological Symposium, Crete, 2009
  15. Spyridonidis A. Donor Lymphocyte Infusions for treatment of relapse in AML. Panhellenic Haematological Symposium, Thessaloniki, 2010

PhD Theses Advisor

  1. Lazana Ioanna, MD University of Patras, Medical School «Role of ΗLA-G molecule in bone marrow transplantation» Presentation : project in progress Publication : Haema 2009: 12 (suppl. 1) 126, Best oral presentation
 

Other Activities

  • Associate Professor of Hematology / Bone Marrow Transplantation in Univeristy of Patras
  • Head of the Bone Marrow Transplantation Program in University of Patras
  • Consultant Hematologist in univeristy Hospital of Patras
  • Head of the BMT Laboratory in University of Patras (Chimerism Lab, HLA Lab, Cyclosporin levels Lab, Biobanking)
  • Scientific Director of the Centre to Advance Public Awareness and Recruitment of Bone Marrow Donor Volunteers University of Patras(CBMDP) (http://www.xarisezoi.gr/)
  • Consultant in Hellenic transplant Organization (EOM)
  • Mentor of the H-Net Masterclass of the European Hematology Association (EHA)
  • Member of the Research Commitee of the Medical School in University of Patras
  • Alternate Member of the Animal Commitee of the Medical School in University of Patras
  • Lecturer (Privat Dozent) of University of Freiburg, Germany