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Hematopoietic

Semester 6th ()

Code MED_631

Hours Teaching 25 hours,2 weeks

Teachers

Description

Description of the disease entities and disease groups of the hematopoietic tissue, with their currently used nomenclature and the latest classification systems.

Presentation of the basic physiology of the hematopoietic tissue / pathophysiology of abnormal hematopoiesis, by incorporating the background knowledge of cellular and molecular biology and biochemistry

Description of the epidemiology and the clinical features of the hematological disorders, both inherited and acquired, benign and malignant.

Presentation of the applied clinical diagnostic approach of the patients, based on the principle of {problem-oriented medical diagnosis”.

Description of 7-8 typical clinical cases from the various disease entities and processing to state of the art differential diagnosis till the confirmation of the final diagnosis.

Demonstration of typical peripheral blood, bone marrow and lymph node smear and histologic pictures, as well as imaging techniques findings for each disease entity.

The educational program in particular consists of:

  • Classification and diagnostic approach of anemia and description of the various etiologic groups of anemia.

  • Anemia of chronic diseases and congenital types of anemias/hemoglobinopathies.

  • Principles of transfusion medicine and indications of supporting transfusions with the various blood products.

  • Classification, pathogenesis and treatment of the congenital and acquired bone marrow failure syndromes.

  • Classification, pathogenesis, clinical manifestations and treatment of acute leukemias.

  • Chronic myeloproliferative neoplasms, myelodysplastic syndromes and overlapping disorders.

  • Epidemiology, classification, pathogenesis, clinical manifestations and treatment of the lymphoproliferative disorders.

  • Multiple myeloma and other plasma cell dyscrasias.

  • Autoimmune blood cytopenias and lysosomal storage disorders.

  • Basic principles of the novel therapeutic approaches, such as immunotherapies, biological treatments on specific molecular targets, hematopoietic stem cell transplantation and cell therapies.

  • Physiology and pathophysiology of blood coagulation, common disorders of hemostasis and thrombosis and their diagnostic approach.

Scope

This course makes an initial description of the diseases of the hematopoietic tissue, starting from the normal structure and function of the hematopoietic cells. It analyzes the pathogenesis, epidemiology, clinical manifestations, prognosis and the current therapeutic approaches of blood disorders, starting from diagnostic approach of typical clinical cases or clinical scenarios. There are specified tasks for each educational area and description of the various disease entities is relied on the currently used classification schemes. The course spend more time on the most commonly and epidemiologically more frequent diseases / disease groups, which are described in depth to the point of molecular pathology/pathophysiology. On the contraire, precise therapeutic options are not described in detail, but emphasis is given in understanding the principles of therapeutics and the general concepts of treatment strategies.

After fulfilling this course the student should know:

  • The principles of normal hematopoiesis and its derrangements

  • The basis disease entities and disease groups of blood disorders

  • The epidemiology, classification, etiopathogenesis, pathophysiology, clinical manifestations, prognosis and treatment approaches of the congenital and the acquired disorders of the hematopoietic tissue.

  • The principles of transfusion therapy and the indications for supportive transfusion of the various blood products.

  • The basic aspects of the current treatment approaches, such as immunotherapy, targeted biological treatments, stem cell transplantation and cell therapies.

The students should realize that this is a rapidly expanding area of the Internal Medicine, with fast development of knowledge and understanding of the pathogenesis of blood diseases, as well as in the design and incorporation of novel treatment strategies and perspectives, resulting in continuous reconstruction and re-identification of the diagnostic criteria and disease management.

Reading Material

- Recommended basic literature: Williams Hematology 9th Edition 2016 Mc Graw-Hill, Harrison’s Principles of Internal Medicine 19th Edition.

- Area scientific Journals: Blood, Haematologica, Leukemia, Bone Marrow Transplantation, Transfusion, Journal of Thrombosis and Hemostasis.