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BRAVOU VASSILIKI, Professor

BRAVOU VASSILIKI

Sector: Division of Basic Medical Sciences II

Clinic/Laboratory: Department of Anatomy

Knowledge Subject: Macroscopic, Microscopic and Molecular Anatomy

Research Area: Cancer molecular pathology (mechanisms of invasion and metastasis, tumour microenvironment, actin cytoskeleton and integrin -associated proteins, TGF- signaling, EMT) and Renal Pathology.

Department of Anatomy-Histology, Embryology, School of Medicine, University of Patras, 26500, Rio Patras, Greece

+30 2610969196, +30 2610969195 +30 2610969178 vibra@upatras.gr

Download Curriculum Vitae

Summary of Curriculum Vitae

Dr Vasiliki Bravou is a physician obtained her MD with distinctions in 2001 at the School of Medicine, University of Patras. She holds an Msc (2003) and a PhD (2006) from Medical School, University of Patras. Dr Bravou was trained in Pathology (2007-2011) at the Department of Pathology, Agios Andreas, Hospital of Patras and also at the Department of Histopathology, Hammersmith Hospital, London UK (2010), where she specialized in Renal Pathology and Electron Microscopy under the supervision of Prof T. Cook. In 2011 she was appointed as an Assistant Professor at the Department of Anatomy, Medical School, University of Patras.She teaches Anatomy, Histology and Embryology in first and second year medical students and co-ordinates and teaches the pregraduate course Molecular Anatomy. She also co-ordinates the post graduate course Molecular Anatomy (Postgraduate program Applications of Basic Medical Sciences) and she  teaches various subjects in three Postgraduate Programs, organized by the University of Patras (Applications of Basic Medical Sciences, Life science informatics, Biomedical Engineering). Her research focuses on: 1.Cancer molecular pathology (mechanisms of invasion and metastasis, tumour microenvironment, actin cytoskeleton and integrin -associated proteins, TGF- signaling, EMT, cancer stem cells and chemoresistanse)2.  Renal Pathology )  3.Molecular pathogenesis of cardiovascular diseases. Dr. Bravou has published over 27  original articles in high-impact peer reviewed journals in her field (Citations: 491, h-index:13, I-10 index: 14), she has participated as a collaborating investigator/researcher in 4 national grants and she is involved in national and international collaborations in the field of cancer biology-pathology and renal pathology.

Undergraduate Courses

Postgraduate Courses

  1. Molecular Anatomy (Co-ordinator). Msc: Applications of Basic Medical Sciences. Medical School, University of Patras
  2. Pathobiology.  Applications of Basic Medical Sciences.Medical School, University of Patras
  3. Research Methodology II. Msc: Applications in Basic Medical Sciences, Medical School, University of Patras
  4. Invited speakers seminars.  Msc: Applications in Basic Medical Sciences.Medical School, University of Patras
  5. Anatomy. Msc: Biomedical Engineering and Medical Physics, University of Patras
  6. Structure and function of the human body. Msc: Life sciences informatics.  University of Patras

Selected Publications

1. Mitsos S, Koletsis EN, Katsanos K, Bravou V, Kolonitsiou F,
Marinos E, Flordellis CS, Dougenis D. Intramyocardial thrombin promotes angiogenesis and improves cardiac function in an experimental rabbit model of acute
myocardial infarction. J Thorac Cardiovasc Surg 2013 [Epub ahead of print)

2. Gialmanidis IP, BravouV, Petrou I , Kourea H ,Mathioudakis A, Lilis I, Papadaki H. Expression of Bmi1, FoxF1, Nanog and γ-catenin in relation to Hedgehog signaling pathway in human non-small cell lung cancer. Lung. 2013;191(5):511-213. 

3. Bravou V, Galliford J, McLean A, Willicombe M, Taube D, Cook HT, Roufosse C. A case of chronic antibody-mediated rejection in the making. Clin Nephrol. 2013;80(10):306-9.

4. Katsanos K, Mitsos S, Koletsis E, Bravou V, Karnabatidis D, Kolonitsiou F, Diamantopoulos A, Dougenis D, Siablis D.Transauricular embolization of the rabbit coronary artery for experimental myocardial infarction: comparison of a minimally invasive closed-chest model with open-chest surgery.J Cardiothorac Surg. 2012;7:16.

5.Sharma V, Antonacopoulou AG, Tanaka S, Panoutsopoulos AA, Karoulias N, Bravou V*, Kalofonos HP , Episkopou V*. Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer. Cancer Res. 2011;71(20):6438-49*Corresponding author
6. Athanasopoulou A, Aroukatos P, Nakas D, Repanti M, Papadaki H, Bravou V*. Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression.Urol Oncol 2013;31(6):836-42 *Corresponding author
7. Bravou V, McLean AG,Loucaidou Μ, Cairns TD Cook ΗT, Roufosse CA. Praproteins zippers. Kidney Int. 2011;80(1): 126
8. Antonacopoulou AG, Floratou K, Bravou V, Kottorou A, Dimitrakopoulos FI, Marousi S, Stavropoulos M, Koutras AK, Scopa CD, Kalofonos HP. Τhe survivin -31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival. Cell Oncol. (Dordr). 2011;34(4):381-91
9. Sotiropoulou N, Bravou V*, Kounelis S, Damaskou V, Papaspirou E, Papadaki H.Tumour expression of lymphangiogenic growth factors but not lymphatic vessel density is implicated in human cervical cancer progression. Pathology. 2010;42(7):629-36*Corresponding author.
10. Papanikolaou S, Bravou V*, Gyftopoulos K, Nakas D, Repanti M, Papadaki H. ILK expression in human basal cell carcinoma correlates with epithelial-mesenhymal transition markers and tumour invasion. Histopathology 2010; 56: 799-809. *Corresponding author
11. Peroukides S, Bravou V*, Alexopoulos A, Varakis J, Kalofonos H, Papadaki H. Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin. Histol Histopath 2010, 25(3): 299-307. *Corresponding author
12. Klironomos G, Bravou V, Papachristou DJ, Gatzounis G, Varakis J, Parassi E, Repanti M, Papadaki H. Loss of inhibitor of Growth (ING-4) is implicated in the pathogenesis and progression of Human astrocytomas. Brain Pathol. 2010;20(2):490-7.
13. Alexopoulos A, Bravou V, Peroukides S, Kaklamanis L, Varakis J, Alexopoulos D, Papadaki H. Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves Int J Cardiol. 2010;139(2):142-9.
14. Bravou V, Antonacopoulou A, Papadaki H, Floratou K, Stavropoulos M, Episkopou V, Petropoulou C, Kalofonos. H. TGF-β repressors SnoN and Ski are implicated in human colorectal carcinogenesis. Cell Oncol. 2009; 31(1):41-51.
15. Gialmanidis IP, Bravou V, Amanetopoulou SG, Varakis J, Kourea H, Papadaki H. Overexpression of hedgehog molecules and FOXM1 in non-small cell lung carcinomas. Lung Cancer. 2009; 66: 64-74
16. Peroukides S, Bravou V*, Varakis J, Alexopoulos A, Κalofonos H, Papadaki H.ILK overexpression in human hepatocellular carcinoma and liver cirrhosis correlates with activation of Akt. Oncol Rep. 2008;20(6):1337-44. *Corresponding author
17. Goulioumis AK, Bravou V, Varakis J, Goumas P, Papadaki H. Integrin-LinkedKinase cytoplasmic and nuclear expression in laryngeal carcinomas Virchows Archiv. 2008; 453(5): 511-9
18. Kalogianni DP, Bravou V, Christopoulos TK, Ioannou PC, Zoumbos NC. Dry reagent disposable dipstick test for visual screening of seven leukemia-related chromosomal translocations Nucleic Acids Res. 2007; 35(4) e23
19. Bravou V, G Klironomos, Papadaki E, S Taraviras S, Varakis J. ILK overexpression in human colon cancer progression correlates with activation of β-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. J Pathol, 2006; 208: 91-99.
20. Bravou V, Klironomos G, Papadaki E, Stefanou D, Varakis J. Integrin-linked kinase (ILK) expression in human colon cancer. Br J Cancer 2003; 89 (12): 2340-1.

 

Selected Presentations

10/2009. Integrin-linked kinase: new insights in signaling and cancer. 14th World Congress on Advances in Oncology and 12th International symposium on Molecular medicine, Loutraki, Greece.
5/2009. Molecular Anatomy of the renal corpuscle.  11th Hellenic Congress of Pathology, Patras, Greece
 

PhD Theses Advisor

Athanasopoulou A. PhD Title: The role of actin-cytoskeleton associated proteins in human urothelial bladder tumors
 
Supervisor of 4 Msc Students (G. Tsinias, P. Chalmouki, E. Aggelou and  D. Tsoumas)

Other Activities

-Member of the teaching laboratories committee.
-Member of the Editorial Board of Americal Journal of Cancer Research
-Reviewed Grants for:
• Fundação para a Ciência e a Tecnologia, Portugal (2006)
Reviewed Manuscripts for:
-Pathology, PLOS one, Disease Markers,BMC Cancer, Digestive and Liver Disease