School of Medicine
University of Patras
>University of Patras
Personel - MOUZAKI AT.



Sector: Division of Internal Medicine Ι

Clinic/Laboratory: Department of Internal Medicine

Knowledge Subject: Laboratory Hematology and Transfusion Medicine

Research Area: Immunology (molecular, cellular, clinical), Immunohematology, Hematology

Laboratory of Immunohematology, Division of Hematology, Dpt. of Internal Medicine, Medical School, University of Patras, Rion, Patras GR-26500, Greece Build. "GIANNIS VARAKIS", 1st floor, west wing


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Download Curriculum Vitae

Summary of Curriculum Vitae

1977: High School Diploma from 2nd Lyceon for Girls (Patras, Greece). 1979: General Certificates of Education(GCEs) in Chemistry, Physics, Mathematics and English (Cambridge Board, UK). 1983: Bachelor's degree (B.Sc./Honors) in Biological Sciences (Major: Physiology, Specialization: Cellular Toxicology) (University of Plymouth, UK). Diploma thesis: “Response of the lymphoid organs of the laboratory mouse to Plasmodium yoelli infection”. 1985: Master's degree (MSc.) in Biological Sciences (Immunology) (University of Salford, UK). MSc thesis: “Gasterosteus aculeatus, Linnaeus: The lymphoid system, diseases and ecological correlates”. 1988: Doctor of Philosophy (Ph.D.) (University of Salford, UK and Free University of Berlin, DE). Ph.D. thesis: “The rat receptor for Interleukin-2”. Positions/Teaching appointments: 1983-1985: Part-time lecturer and demonstrator, Laboratory of Immunology, University of Salford, Greater Manchester, UK. 1985-1987: Research assistant, Institute of Immunology, Medical School, Klinikum Steglitz, Berlin, Germany. 1987-1990: Assistante post-doctorante, Dpt. of Molecular Biology, University of Geneva, Geneva, Switzerland. 1991-1992: Assistante post-doctorante, Dpt. of Hematology, Medical School and University Hospital, Geneva, Switzerland. 1992-1995: Maitre Assistante, Dpt. of Hematology, Medical School and University Hospital, Geneva, Switzerland. 1995-1997: Lecturer of Laboratory Hematology and Transfusion Medicine, Medical School, University of Patras, Patras, Greece. 1997-2003: Assistant Professor of Laboratory Hematology and Transfusion Medicine, Medical School, University of Patras, Patras, Greece. 2003-2009: Associate Professor of Laboratory Hematology and Transfusion Medicine, Division of Hematology, Dpt. of Internal Medicine, Medical School, University of Patras, Greece. Current appointment: Professor of Laboratory Hematology and Transfusion Medicine, Division of Hematology, Dpt. of Internal Medicine, Medical School, University of Patras, Greece. Director of the Immunohematology Laboratory.

Undergraduate Courses

Postgraduate Courses

1996-now: Participation in post-graduate courses of the post-graduate program “Basic Medical Sciences” (Faculty of Medicine, University of Patras). Teaching (hours per year) in:

Research methodology [28h]-coordinator of unit II

How to write scientific papers [6h]

Current topics of biological research [4h]-coordinator (1/2)

Immunology [20 h]

Practical training in Immunohematology and Immunology [40h]

1997-now: Participation in the post-graduate program “Medicinal Chemistry” (Faculty of Medicine and Dpt. of Chemistry, University of Patras). Teaching the unit: “Basic and Translational Immunology” [26h]

2001-2011: Participation in the post-graduate program of the Dpt. of Biology, Univ. of Patras. Teaching the unit: “The immune response” [20h]

2004-2011: Participation in the post-graduate program “Clinical and Laboratory Medicine” (Faculty of Medicine, University of Patras). Teaching the unit: “How to write science papers” [4h]
2022-now: Participation in the post-graduate program "Cell and Gene Therapies" (Faculty of Medicine University of Patras & University of West Attica) [8h]

Selected Publications

Di Stefano R, Mouzaki A, Araneda D, Diamanstein T, Tilney NL, Kupiec-Weglinski JW. 1988. Anti-interleukin 2 receptor monoclonal antibodies spare phenotypically distinct T suppressor cells in vivo and exert synergistic biological effects. J. Exp. Med., 167(6):1981-1986.

Mouzaki A, Weil R, Muster L, Rungger D. 1991. Silencing and trans-activation of the mouse IL-2 gene in Xenopus oocytes by proteins from resting and mitogen-induced primary T-lymphocytes. EMBO J., 10(6):1399-1406.

Hentsch B, Mouzaki A, Pfeuffer I, Rungger D, Serfling E. 1992. The weak, fine-tuned binding of ubiquitous transcription factors to the IL-2 enhancer contributes to its T cell-restricted activity. Nucleic Acids Res., 20(11):2657-2665.

Mouzaki A, Rungger D, Tucci A, Doucet A, Zubler RH. 1993. Occurrence of a silencer for the interleukin-2 gene in naïve but not memory resting T helper cells. Eur. J. Immunol. 23(7):1469-1474.

Mouzaki A, Rungger D. 1994. Properties of transcription factors regulating interleukin 2 gene transcription through the NFAT binding site in untreated or drug-treated naïve and memory T helper cells. Blood, 84(8):2612-2621.

Mouzaki A, Matthes T, Miescher PA, Beris P. 1995. Polyclonal hypergammaglobulinaemia in a case of B cell Chronic Lymphocytic Leukaemia: The result of IL-2 production by the proliferating monoclonal B cells? Br. J. Haematol., 91(2):345-349.

Mouzaki A, Doucet A, Mavroidis E, Muster L, Rungger D. 2000. A repression-derepression mechanism regulating the transcription of human immunodeficiency virus type 1 in primary T cells. Mol. Med., 6(5):377-390.

Mouzaki A, Theodoropoulou M, Gianakopoulos I, Vlaha V, Kyrtsonis M-C, Maniatis A. 2002. Expression Patterns of Th1 and Th2 Cytokine Genes in Childhood Idiopathic Thrombocytopenic Purpura (ITP) at Presentation and their Modulation by Intravenous Immunoglobulin G (IVIg) Treatment; their Role in Prognosis. Blood, 100(5):1774-1779.

Panitsas F, Theodoropoulou M, Kouraklis A, Karakantza M, Theodorou G, Zoumbos NC, Maniatis A & Mouzaki A. 2004. Adult chronic idiopathic thrombocytopenia purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood, 103(7):2645-2647.

Argyropoulos C, Nikiforidis GC, Theodoropoulou M, Adamopoulos P, Boubali S, Georgakopoulos TN, Paliogianni F, Papavassiliou AG, Mouzaki A. 2004. Mining microarray data to identify transcription factors expressed in naïve resting but not activated T lymphocytes. Genes Immun., 5(1):16-25.

Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A. 2004. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS). In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients. J. Autoimmun., 23(2):169-177.

Matsoukas J, Apostolopoulos V, Kalbacher H, Papini A-M, Tselios T, Chatzantoni K, Biagioli T, Lolli F, Deraos S, Papathanassopoulos P, Troganis A, Mantzourani E, Mavromoustakos T, Mouzaki A. 2005. Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: Enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators. J. Med. Chem., 48(5):1470-1480.

Fourtounas C, Mouzaki A, Vlachojannis JG. 2008. Desensitization during renal transplantation. NEJM, 359(16):1731.

Papanastasiou AD, Chatzantoni K, Mouzaki A. 2008. Current therapeutic leads for the treatment of autoimmune diseases: stem cell transplantation and inhibition of post-translational modifications of autoantigens. Exp. Opin. Drug Disc., 3(10):1255-1265.

de Lastic A-L, Rodi M, Mouzaki A. 2016. Effect of dendritic cell state and antigen-presentation conditions on resulting T-cell phenotypes and Th cytokine profiles. Immunobiology, 221(8):862-870.

Rodi M, Dimisianos N, de Lastic A-L, Sakellaraki P, Deraos G, Matsoukas J, Papathanasopoulos P, Mouzaki A. 2016. Regulatory cell populations in Relapsing-Remitting Multiple Sclerosis (RRMS) Patients: Effect of Disease Activity and Treatment Regimens. Int. J. Mol. Sci., 17(9):1398, pp.1-17.

Panagoulias I, Georgakopoulos T, Aggeletopoulou I, Agelopoulos M, Thanos D, Mouzaki A. 2016. Transcription Factor Ets-2 Acts as a Pre-induction Repressor of Interleukin-2 (IL-2) Transcription in Naive T Helper Lymphocytes. J. Biol. Chem., 291(52):26707-26721.

Panagoulias I, Karagiannis F, Aggeletopoulou I, Georgakopoulos T, Argyropoulos CP, Akinosoglou K, Gogos C, Skoutelis A, Mouzaki A. 2018. Ets-2 acts as a transcriptional repressor of the human immunodeficiency virus type 1 through binding to a repressor-activator target sequence of 5’-LTR. Front. Immunol., 8:1924.

Psianou K, Panagoulias I, Papanastasiou AD, de Lastic A-L, Rodi M, Spantidea PI, Degn SE, Georgiou P, Mouzaki A. 2018. Clinical and immunological parameters of Sjögren’s syndrome. Autoimmun. Rev., 17(10):1053-1064.

Davoulou P, Aggeletopoulou I, Panagoulias I, Georgakopoulos T, Mouzaki A. 2020. Transcription factor Ets-2 regulates the expression of key lymphotropic factors. Mol. Biol. Rep., 47(10):7871-7881.

Triantos C, Aggeletopoulou I, Thomopoulos K, Mouzaki A. 2021. Vitamin D - liver disease association: Biological basis and mechanisms of action. Hepatology, 74(2):1065-1073.

Tourkochristou E, Triantos C, Mouzaki, A. 2021. The influence of nutritional factors on immunological outcomes. Front. Immunol., 12:665968.

Thomas I, Panagoulias I, Aggeletopoulou I, Varvarigou A, Spiliotis BE, Mouzaki A. 2021. The role of leptin in childhood immune thrombocytopenia (ITP): an anti-inflammatory agent? Int. J. Mol. Sci., 22(14):7636.

Triantos C, Aggeletopoulou I, Mantzaris GJ, Mouzaki A. 2022. Molecular basis of vitamin D action in inflammatory bowel disease. Autoimmun. Rev., 21(8):103136.

Panagoulias I, Charokopos N, Iason Thomas I, Spantidea PI, de Lastic AL, Rodi M, Anastasopoulou S, Aggeletopoulou I, Lazaris C, Karkoulias K, Leonidou L, Georgopoulos NA, Markou KB, Mouzaki A. 2023. Shifting gears: study of immune system parameters of male habitual marathon runners. Front. Immunol., 13:1009065.

Anastasopoulou S, Georgakopoulos T, Mouzaki A. 2023. HIV-1 transcriptional activator Tat inhibits IL-2 expression by preventing the presence of Pol II on the IL2 promoter. Biomolecules, 13(6):881.

Gakis G, Angelopoulos I, Panagoulias I, Mouzaki A. 2024. Current knowledge on multiple sclerosis pathophysiology, disability progression assessment and treatment options, and the role of autologous hematopoietic stem cell transplantation. Autoimmun. Rev., 23(2):103480.


Selected Presentations

Participation in 125 international and national scientific meetings (invited in 89).

PhD Theses Advisor

Supervisor in 18 Ph.D. Theses (15 completed)

Supervisor in 42 MSc. theses (completed)

Supervisor in 14 Diploma projects (12 completed).

Co-supervisor and member of the examination committees of 76 Ph.D. theses (65 completed) and 20 MSc. theses (19 completed).

Other Activities

Research grants: Recipient of 34 research grants (PI or co-PI) amounting to approximately 5M €. My share of these grants amounted to 1,441,374 €.

Societies: Member of 11 Scientific Societies. Founding member of the Hellenic Academy of Neuroimmunology.

Clinical duties: Responsible for the Laboratory of the Hellenic Center for Disease Control and Prevention in Patras, Greece. The laboratory measures the HIV viral load and performs HLA-B*5701 typing and genotypic analyses to determine drug-resistance and other mutations of individuals with established HIV-1 infection attending the Division of Infectious Diseases of the University Hospital, Patras, Greece. Responsible for the Laboratory of Molecular Diagnosis of Infectious Agents, Medical School, University of Patras, which runs molecular diagnostic tests for the 6th Health District of Greece for the detection of viruses such as SARS-CoV-2, Monkeypox, Influenza A and B, RSV.

Administrative duties: Established the research laboratory of Immunohematology and participated in the setting and start-up of common research facilities of the Medical School, University of Patras. Member (1/5) of a committee appointed by the Health Ministry to design the application of molecular testing for viruses in the Blood Centers of Greece. Established the Laboratory of Molecular Diagnosis of Infectious Agents of the Medical School, University of Patras. Member (1/3) of a committee that runs the quality control of the post-graduate course “Biomedical Sciences” of the Medical School, University of Patras. Member of the General Assembly of the Medical School, University of Patras, for the acad. years 1995-96, 1998-99, 2001-02, 2006-07, 2011-12, 2015-24. Member (since 1995) of a committee that organizes and supervises the laboratory courses of the students of the Medical School, University of Patras. Head of the committee since 2009. Vice President of the post-graduate program Medicinal Chemistry & Biological Chemistry (Dpt. of Chemistry and Medical School, University of Patras) for acad. years 2018-24. Member of electoral boards for the election of faculty in Hematology and Immunology in all Greek Universities and the Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Editorial duties: Section Editor, International Journal of Molecular Sciences, MDPI / Topic Editor, International Journal of Molecular Sciences, MDPI, Section: Molecular Immunology / Member of the Editorial Board, Biomolecules, MDPI / Member of the Editorial Board, International Journal of Molecular Sciences, MDPI / Topic Editor, Frontiers in Immunology / Associate Editor, Frontiers in Immunology