School of Medicine
University of Patras
>University of Patras
Personel - LIOSSIS ST.



Sector: Division of Internal Medicine Ι

Clinic/Laboratory: Department of Internal Medicine

Knowledge Subject: Rheumatology

Research Area: Systemic Lupus Erythematosus B and T cell physiology Signal transduction in human lymphocytes

Division of Rheumatology Dept of Internal Medicine Patras University Hospital 26504 Rion 1st floor, Rheumatology Outpatient Clinic

+302613603693 +302610993982

Download Curriculum Vitae

Summary of Curriculum Vitae

I was born in Canada (1962) and I reside at Patras, Greece.  I graduated from the University of Patras Medical School (1979-1985) and later on (1999) I obtained my PhD degree from the same school.  I specialized in Rheumatology (1995).  During the same year, funded by a scholarship from the Greek Rheumatology Association, I trained at the Department of Clinical Physiology (Uniformed Services University for the Health Sciences [USU], Bethesda, MD) and the Department of Cellular Injury (Walter Reed Army Institute of Research, Washington DC) for approximately 3 years.  During the latest 2 years of them I was appointed Assistant Professor of Medicine at the Edward Hebert School of Medicine at USU.  On my return to Greece I worked as an associate at the 1st Propedeutic Dept of Medicine, University of Athens Medical School, for 2 years (1998-2000).  On 2002 I got elected as a Lecturer in Medicine / Rheumatology at the University of Patras Medical School, Dept of Internal Medicine, Division of Rheumatology.  On 2007 I got elected as Assistant Professor and on 2012 as Associate Professor of Medicine at the same school.
My research interests are the study of the T and B cells from patients with Systemic Lupus Erythematosus.  On this issue I have written and published original articles, reviews and book chapters from 1996 until today (>2000 citations, h-index: 23).  Currently I am involved in the Rheumatology outpatient clinic, I teach medical students (year 1 through year 6) and perform / supervise research scientists at the Researh Rheumatology Laboratory of our Department.

Undergraduate Courses

Postgraduate Courses

  • ΠΒ4. Αρχές Νοσολογίας, Ιατρικής Πρακτικής και Μεθοδολογίας (ΔΠΜΣ ΠΕΖ)
Life Sciences Informatics: University of Patras

Selected Publications

  1. Liossis SN, Kovacs B, Dennis G, Kammer GM, Tsokos GC. B cells from patients with systemic lupus erythematosus display abnormal antigen-receptor-mediated early signal transduction events. Journal of Clinical Investigation 1996; 98:2549-57.
  2. Liossis SN, Ding XZ, Kiang JG, Tsokos GC. Overexpression of the heat-shock protein 70 enhances the TCR/CD3- and the Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells. Journal of Immunology 1997; 158:5668-75.
  3. Liossis SN, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T-cell receptor zeta chain. Journal of Clinical Investigation 1998; 101:1448-57.
  4. Tsokos GC, Liossis SN. Immune cell signalling in lupus: activation, anergy and death. Immunology Today 1999; 20:119-24.
  5. Liossis SN, Solomou EE, Dimopoulos MA, Panayiotidis P, Mavrikakis M, Sfikakis PP. B-cell kinase Lyn deficiency in patients with systemic lupus erythematosus. Journal of Investigative Medicine 2001; 49:157-165. Enyedy EJ,
  6. Nambiar MP, Liossis SN, Dennis GJ, Kammer GM, Tsokos GC. Fcε receptor type I γ chain replaces the deficient T cell receptor ζ chain in T cells οf patients with systemic lupus erythematosus. Arthritis & Rheumatism 2001; 44:1114-1121.
  7. Katsiari CG, Liossis SN, Souliotis VL, Dimopoulos MA, Manoussakis MN, Sfikakis PP. Αberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus. Clinical Immunology 2002; 103:54-62.
  8. Katsiari CG, Liossis SN, Dimopoulos AM, Charalambopoulos DV, Mavrikakis M, Sfikakis PP. CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition. Lupus 2002; 11:370-
  9. Liossis SN, Tsokos GC. Monoclonal antibodies and fusion proteins in medicine. Journal of Allergy and Clinical Immunology 2005; 116:721-9.
  10. Liossis SN, Bounas A, Andonopoulos AP. Mycophenolate mofetil as first-line treatment improves early clinically evident scleroderma lung disease. Rheumatology 2006; 45:1005-8.
  11. Liossis SN, Sfikakis PP. Rituximab-induced B-cell depletion in autoimmune diseases: potential effects on T cells Clinical Immunology 2008; 127:280-5.
  12. Kalliolias GD, Liossis SN. The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still’s disease and systemic-onset juvenile idiopathic arthritis. Expert Opinion on Investigational Drugs 2008; 17:349-59.
  13. Equally first author. Daoussis D, Liossis SN, Tsamandas AC, Kalogeropoulou C, Kazantzi A, Sirinian C, Karampetsou M, Yiannopoulos G, Andonopoulos AP. Experience with Rituximab in scleroderma. A 1-year proof-of-principle study. Rheumatology 2010; 49:271-80 (E-pub: May 2009). 
  14. Equally first author. Daoussis D, Liossis SN, Solomou EE, Tsanaktsi A, Bounia K, Karampetsou M, Yiannopoulos G, Andonopoulos AP. Evidence that Dickkopf-1 is dysfunctional in ankylosing spondylitis. Arthritis and Rheumatism 2010; 62; 150-8. Equally First author.
  15. Crispin JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends in Molecular Medicine 2010; 12:47-57.

PhD Theses Advisor

  1. 1. Effects of rituximab treatment on the Treg and Th17 subpopulations in patients with rheumatoid arthritis 2. Analysis of the Th1/17 T cell subpopulation in patients with Systemic Lupus erythematosus. 3. Effects of B cell depletion treatment on T cell subpopulations in patients with diffuse scleroderma

Other Activities

I am a Reviewer (ad hoc) for 28 different international scientific journals focusing on Immunology and Rheumatology. Among them prestigious journals such as the Journal of Immunology, Arthritis & Rheumatism, Arthritis Research & Treatment and Rheumatology can be found. I am an Academic Editor for PLoS ONE and also a member for 4 additional journals such as the Frontiers in Immunology and Clinical Immunology. I have reviewed research grants for funding from the Israel Science Foundation and from the Dutch Arthritis Association. I am the Greek Delegate in EULAR for "Clinical Affairs". I have been awarded the 1st John F. Maher Award for Research Excellence (USA) and 4 additional awards from the Hellenic Rheumatism Association. I am a member (elected) of the American College for Rheumatology (ACR) and of the Greek Society for Rheumatology. Finally, I have been awarded with the "Certificate for Reviewing Excellence" from the journal Clinical Immunology.