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PALIOGIANNI FOTINI, Professor

PALIOGIANNI FOTINI

Sector: Division of Clinical Laboratories

Clinic/Laboratory: Department of Microbiology

Knowledge Subject:

Research Area: MICROBIOLOGY-IMMUNOLOGY

DEPARTMENT OF MICROBIOLOGY UNIVERSITY OF PATRAS MEDICAL SCHOOL 3RD FLOOR

2610996111, 2610993978 261-994922 FPAL@UPATRAS.GR fpal@med.upatras.gr

Download Curriculum Vitae

Summary of Curriculum Vitae

Dr. Fotini Paliogianni a graduate from the Patras Medical School (1984) obtained her PhD from the same University in 1991. She had her training in Microbiology at the Department of Microbiology, University Hospital of Patras and she was board certified in Microbiology in 1990. She continued her studies at the National Institutes of Health (NIH), Bethesda MD, USA, as a postdoctoral fellow in Cellular and Molecular Immunology from 1990-1993, and worked as a visiting scientist in the same department during the years 1994, 1995 and 1996. From 1994 she joined the faculty at the Department of Microbiology, University of Patras Medical School, initially as lecturer and now as a professor of Microbiology-Immunology. Her expertise lies in the fields of the biology of the immune response and host defense against infection. Her work, using immunosupressine drugs as model, first delineated the signal transduction pathways (Ca++ and cAMP dependent) leading to lymphocyte activation. More recent work is focused in innate immunity mechanisms involved in host defense against P. aeruginosa and Brucella. Her laboratory combines a collection of molecular, genetic, and biochemical approaches to elucidate the role of bacterial products in the regulation of the inflammatory response, the development of innate immunity, and dissect signalling events that are initiated by innate immunity receptors and lead to regulatory/ inflammatory cytokine production. Dr. Paliogianni successfully mentored 6 Ph.D. students and she has active collaborations with research labs at Medical Schools of Crete and Thessaloniki, School of Biotechnology in Ioannina and Biomedical Research Foundation in Athens.

Undergraduate Courses

Postgraduate Courses

  • Ερευνητική Μεθοδολογία (ΠΜΣ - ΚΚΙΕ)

Selected Publications

  1. Paliogianni F., Raptis A., Ahuja S.S., Najjar S., Boumpas D.T.: Negative transcriptional regulation of the human interleukin 2 gene by glucocorticoids through interference with nuclear factors AP-1 and NF-AT. J. Clin. Invest. 91: 1481-1489, 1993. 
  2. Paliogianni F., Ahuja S.S., Ballow J.P., Balow J.E., Boumpas D.T.: Novel mechanism for inhibition of T-cells by glucocorticoids (GC): GC modulate signal transduction through IL-2 receptor. J. Immunol. 151: 4081-4089, 1993. 
  3. Paliogianni F., Kincaid R.L., Boumpas D.T.: Prostaglandin E2 and other cAMP elevating agents inhibit interleukin-2 gene transcription by counteracting calcineurin dependent pathways. J. Exp. Med. 178: 1813-1817, 1993. 
  4. Paliogianni F., Hama N., Balow J.E., Valentine M.A., Boumpas D.T.: Glucocorticoid mediated regulation of phosphorylation in primary induction of phosphatase activity. J. Immunol. 155: 1809-1817, 1995. 
  5. Paliogianni F., Boumpas D.T.: Glucocorticoids regulate calcineurin - dependent trans - activation pathways for interleukin-2 gene transcription in human T lympocytes . Transplantation 59: 1333-1339, 1995. 
  6. Hama N., Paliogianni F., Fessler B.J., Boumpas D.T.: Calcium/calmodulin dependent protein Kinase II downregulates both calcineurin and protein Kinase C mediated pathways for cytokine gene transcription in human T cells. J. Exp. Med. 181: 1217-1222, 1995. 
  7. Paliogianni F., Hama N., Mavrothalassitis G., Thyphronitis G., Boumpas D.T.: Signal requirements for IL-4 gene transcription during T-cell activation. Cellular Immunology 168: 33-38, 1996. 
  8. Paliogianni F., Boumpas D.T.: PGE2 inhibits the nuclear transcription of the human interleukin-2 but not the IL-4 gene in human T cells by targeting transcription factors AP-1 and NF-AT. Cellular Immunology 170: 1-7, 1996. 
  9. G.Lagoumintzis, M.Christofidou, G.Dimitracopoulos, F.Paliogianni: Pseudomonas aeruginosa slime glycolipoprotein is a potent stimulant of tumor necrosis factor alpha gene expression and activation of transcription activators nuclear factor kappa B and activator protein 1 in human monocytes. Infect. Immun.71:4614-4622,2003. 
  10. Olga Kogkopoulou, , Evaggelos Tzakos, George Mavrothalassitis, Cosima T. Baldari, Fotini Paliogianni, Howard A. Young, and George Thyphronitis. Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity. J. Leuc. Biol 79, 2006: 1052-1060. 
  11. Simitsopoulou M. Roilides E. Likartsis C. Ioannidis J. Orfanou A. Paliogianni F. Walsh TJ: Expression of Immunomodulatory genes in human monocytes induced by Voriconazole in the presence of Aspergillus fumigatus. Antimicrob. Agents Chemother. 2007, 51(3): 1048-54. 
  12. G.Lagoumintzis, P.Xaplanteri, G. Dimitracopoulos & F.Paliogianni :TNF-alpha Induction by Pseudomonas aeruginosa Lipopolysaccharide or Slime-glycolipoprotein in Human Monocytes is Regulated at the Level of Mitogen-activated Protein Kinase Activity: A Distinct Role of Toll-like Receptor 2 and 4. Scand. J. Immunol 2008, 67(2):193-203. 
  13. K.Liopeta, S.Boubali, L.Virgilio, G.Thyphronitis, G.Mavrothalassitis, G.Dimitracopoulos, F. Paliogianni: cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: a potential role for MEF2. Mol Immunol. 2009 46(3):345-354 
  14. P. Xaplanteri, G.Lagoumintzis, G. Dimitracopoulos, F.Paliogianni: Mannose receptor controls in synergy with TLR2 proinflammatory cytokine production by human monocytes in response to Pseudomonas aeruginosa. Eur J Immunol. 2009 39(3):730-40 
  15. A. Katragou, Kruhlak MJ, Simitsopoulou M, Chatzimoschou A, Taparkou A, Cotten CJ, Paliogianni F, Diza-Mataftsi E, Tsantali C, Walsh TJ, Roilides E: Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents. J. Infect. Dis. 2010 201(12): 1941-49.

PhD Theses Advisor

  1. Lagoumintzis George: Signal transduction pathways leading to proinflammatory cytokine production in response to Pseudomonas aeruginosa slime glycolipoprotein. Presented on 2004.
  2. Xaplanteri Panagiota: The role of innate immunity receptors in recognition of Pseudomonas aeruginosa by human monocyte/ macrophages. Presented on 2008.
  3. Liopeta Kassianni: Regulation of cytokine production by c-AMP dependent pathway in normal lymphocytes. Presented on 2008.
  4. Boubali Stavroula: Regulation of IL-10 production by calcium dependent pathway in normal lymphocytes. Presented on 2009.
  5. Dimitrakopoulos Odysseas: Mechanisms of innate immunity involved in Brucella infection chronicity. On going

Other Activities

Dr. Fotini Paliogianni was a member of the organizing committee for the development and application of the reformed undergraduate medical curriculum of Patras Medical School. She teaches Microbiology, Immunology and Research Bioethics at undergraduate level and Research Methodology at postgraduate level. She developed the training curriculum in Basic and Diagnostic Immunology for residents of Biopathology in the Microbiology Department of University of Patras teaching hospital and for a decade teaches Immunology of Host Defense, participating in education seminars organized by Greek Society for Immunology. From 1993 until now she worked as senior scientist in all the sections of Diagnostic Microbiology Department at the University of Patras teaching hospital, training residents in Biopathology. From 2009 is in charge of the Diagnostic Immunology Section of the same department, which covers a great variety of immunological tests for diagnosis of infectious and autoimmune diseases.