Ελληνικά
School of Medicine
University of Patras
>University of Patras
HQA
Personel - DINOS GE.
  1. Home
  3. Personel
  5. Professors

DINOS GEORGE, Professor

DINOS GEORGE

Sector: Division of Basic Medical Sciences I

Clinic/Laboratory: Department of Biochemistry

Knowledge Subject: Biochemistry-Enzymology-Protein Synthesis

Research Area: Structure and Function of prokaryotic Ribosome

Laboratoty of Biochemistry, School of Medicine, University of Patras, 26500-Patras, Greece 3rg, SE wing

2610-996259 2610-969167 dinosg@upatras.gr

Download Curriculum Vitae

Summary of Curriculum Vitae

Academic Position
Associate Professor of Biochemistry
Εducation and Positions
BSc., in Chemistry, Univ. of Athens 1979
PhD in Biochemistry, School of Medicine, Univ. of Patras 1995
 
Research Interests
  • Ribosome biogenesis
  • Development of inhibitors for ribosome biogenesis
  • Combined functional and crystal structure studies of new ketolides effective against macrolides resistant strain

Undergraduate Courses

Postgraduate Courses

Methodology in basic sciences
Molecular basis of Transcription and Translation
Research Activities
Clinical Biochemistry

Selected Publications

  1. Dinos G, Connell S., Nierhaus K and Kalpaxis D (2003) “Erythromycin, roxithromycin and clarithromycin: Use of slow-binding kinetics to compare their in vitro interaction with a ribosomal complex active in peptide bond formation” Mol. Pharmacol. 63, 617-623. 
  2. Connell S, Trieber CA, Dinos G, Εinfeldt E, Taylor D and Nierhaus K. (2003) “Mechanism of Tet(O)-mediated tetracycline resistance” EMBO J. 22, 945-963. 
  3. Xaplanteri M, Andreou A, Dinos G, and Kalpaxis D.(2003) “Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action “ Nucl. Acids. Res. 31: 5074-5083 
  4. Kalpaxis D, Theos C, Xaplanteri M, Dinos G, Catsiki A and Leotsinidis M (2004) “Biomonitoring of Gulf of Patras, N Peloponnesus, Greece. Application of a biomarker suite including evaluation of translation efficiency in Mylitus galloprovinciallis cells” Environ Res. 94(2):211-20. 
  5. Dinos G, Wilson D, Teraoka Y, Fucini P, Kalpaxis D and Nierhaus K. (2004) “Dissecting the inhibition mechanisms of edeine and pactamycin: Antagonistic interplay on the ribosome between these translational inhibitors” Moll Cell 13: 113-124. (Rated “Must Read” by F1000, http://www.f1000biology.com/article/id/1018199). 
  6. Petropoulos A, Xaplanteri M, Dinos G, Wilson D, and Kalpaxis D. (2004) “Polyamines affect diversely the antibiotic potency: insight gained from kinetic studies of the blasticidin S and spiramycin interactions with functional ribosomes” J Biol Chem. 279(25): 26518-25. 
  7. Xaplanteri M, Petropoulos A, Dinos G and Kalpaxis D (2005) “Localization of spermine binding sites in 23S rRNA by photoaffinity labeling: parsing the spermine contribution to ribosomal 50S subunit functions” Nucl. Acids Res. 33: 2792-805 
  8. Dinos G, Kalpaxis DL, Wilson DN, and Nierhaus K (2005) “Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolysed by EF-Tu”. Nucleic Acids Res., 33, 5291-5296.
  9. Karahalios P, Kalpaxis D, Fu H, Katz L, Wilson D and Dinos G (2006) “On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics” Mol. Pharmacol. 70:1271-1280 
  10. Petropoulos A, Kouvela E, Dinos G, and Kalpaxis D (2008) Stepwise Binding of Tylosin and Erythromycin to Escherichia coli Ribosomes, Characterized by Kinetic and Footprinting Analysis. J Biol Chem 283(8):4756-65 /li>
  11. Petropoulos AD, Kouvela EC, Starosta AL, Wilson DN, Dinos GP, Kalpaxis D (2008) Time-resolved binding of azithromycin to Escherichia coli ribosomes. J Mol Biol. 385:1179-1192 
  12. Kouvela EC, Kalpaxis DL, Wilson DN, Dinos G. (2009) A distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. Antimicrob Agents Chemother. 53:1411-1419.
  13. Krokidis MG, Kostopoulou ON, Kalpaxis DL, and Dinos G. (2009) Dissecting the ribosomal inhibition mechanism of a new ketolide carrying an aryl-alkyl group at C-13 of its lactone-ring. International Journal of Antimicrobial Agents,35:235-239 
  14. Mamos P, Krokidis M, Papadas A, Karahalios P, Starosta A, Wilson D, Kalpaxis D, and Dinos G (2013) On the use of the antibiotic chloramphenicol to target polypeptide chain mimics to the ribosomal exit tunnel, Biochimie, 95:1765-72 
  15. Krokidis M, Márquez V, Wilson DN,, Kalpaxis D, and Dinos G, (2013) Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesis, Antimicrob. Agents Chemother,in press.

      16. Selected Presentations

      Dinos G (2006) In vitro studies on the interaction between new 16-membered 9-O-arylalkyloxime macrolides with functional ribosomes, 9th Workshop on Experimental Sstrategies for Ribosomal Research, Patras-Psathopyrgos, Greece, 20-25 March 2006.
      Dinos G.(2009) A distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity"10th International Workshop on Experimental Strategies for Ribosome Research;Schloss Ringberg Castle of the Max Planck Society 19th April - 22nd April 2009.

      PhD Theses Advisor

      Supervisor of one PhD student and two Master students

      Other Activities

      Reviewer in many scientific Journals
      Reviewer of National Funding Proposals