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STATHOPOULOS CONSTANTINOS, Professor

STATHOPOULOS CONSTANTINOS

Sector: Division of Basic Medical Sciences I

Clinic/Laboratory: Department of Biochemistry

Knowledge Subject: Biochemistry

Research Area: RNA Biology

University of Patras School of Medicine Department of Biochemistry 1 Asklipiou st., 26504 Rio-Patras, Greece 3rd Floor, West Section

+30 2610 997932 (Office), +30 2610 997936 (Laboratory) +30 2610 969167 cstath@med.upatras.gr

Download Curriculum Vitae

Summary of Curriculum Vitae

ACADEMIC POSITION
Professor and Head
Department of Biochemistry, School of Medicine, University of Patras
Τel. +302610997932, Fax. 2610969167, email: cstath@med.upatras.gr
　
STUDIES
1991 B.Sc, in Biology, University of Patras
1996 Ph.D. in Biochemistry, School of Medicine, University of Patras
1998-2002 Post-doctoral Research Associate, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
　

MAIN RESEARCH INTERESTS

  • RNA Biology
  • RNA-dependent regulation of gene expesssion and translation
  • Non-coding RNAs as biomarkers
  • -Omics in molecular diagnostics and precision medicine

COLLABORATIONS

  • Prof. Hubert Becker, University Louis Pasteur, Starsbourg, FRANCE
  • Dr Jinwei Zhang, NIH-NIDDK, USA
  • Dr Astris Haase, NIH-NIDDK, USA
  • Prof. Michael Ibba, Dept. of Microbiology, Ohio State University, Colombus, OH U.S.A
  • Prof. Dieter Soll, Dept. of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT U.S.A.
  • Prof. Spyridon Pournaras, Dept. of Microbiology, School of Medicine, University of Athens, Greece
  • Prof. George Spyroulias, NMR Center, School of Pharmacy, University of Patras, Greece

Undergraduate Courses

Postgraduate Courses

Graduate courses in the Postgraduate Program “Applications of Basic Medical Sciences”: Molecular mechanisms of transcription and translation (coordinator), Biomedical instrumentation (coordinator), Invited speakers seminars (coordinator), Current bibliography, Current research topics, Biochemistry of disease, Advanced courses in molecular and cellular biology 2012-present, Inter-Departmental Postgraduate Program in University of Patras, Patras, Greece “Life Sciences Informatics” Courses on RNA biology for the “Genes and Genomes” module 2003-present, Department of Biology University of Athens, Postgraduate Program in “Microbial Biotechnology” Courses on “Microbial Systems and their applications”

Selected Publications

  1. Stathopoulos C., Li T., Longman R., Vothknecht U.C., Becker H.D., Ibba M. and Söll D. (2000). One polypeptide with two aminoacyl-tRNA synthetase activities. Science 287:479-482.
  2. Ibba M., Becker H. D., Stathopoulos C., Tumbula D. and Söll D. (2000) The adaptor hypothesis revisited. Trends Biochem Sci 25:311-316.
  3. Kamtekar S., Kennedy D.W., Wang J., Stathopoulos C., Söll D. and Steitz, T.A. (2003) The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases. Proc Natl Acad Sci USA 100: 1673-1678.
  4. Korencic D., Ahel I., Schelert J., Sacher M., Ruan B., Stathopoulos C., Blum P., Ibba, M. and Söll D. (2004) A freestanding proofreading domain is required for protein synthesis quality control in archaea. Proc Natl Acad Sci USA 101:10260-10265.
  5. Bailly M., Giannouli S., Blaise M., Stathopoulos C., Kern D and Becker H. D. (2006) A single tRNA base-pair mediates bacterial tRNA-dependent biosynthesis of asparargine. Nucleic Acids Res 34:6083-6094.
  6. Pournaras S., Ntokou E., Zarkotou O., Ranellou K., Themeli-Digalaki K., Stathopoulos C . and Tsakris A. (2013) Emergence of linezolid-dependent Staphylococcus epidermidis bloodstream isolates. Emerging Infect Dis 19: 129-132.
  7. Saad N. Y., Stamatopoulou V., Drainas D., Stathopoulos C. and Becker H. D. (2013) Τwo-codon T-box riboswitch binding two tRNAs. Proc Natl Acad Sci USA 110:12756-12761.
  8. Kokkori S., Apostolidi M., Tsakris A., Pournaras S., Stathopoulos C. and Dinos G. (2014) Linezolid-dependent structure and function adaptation of ribosomes from linezolid-dependent S. epidermidis. J Antimicrob Chemoth 58: 4651-4656.
  9. Apostolidi M., Saad N. Y., Drainas D., Pournaras S., Becker H. D. and Stathopoulos C. (2015) A glyS T-box riboswitch with species-specific structural features responding to both proteinogenic and non-proteinogenic tRNAGly isoacceptors. RNA 21:1790-1806. (Cover Featured Article)
  10. Anastasakis D., Skeparnias I., Shaukat N-A., Grafanaki K., Kanellou A., Taraviras S., Papachristou D. J., Papakyriakou A. and Stathopoulos C. (2016) Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development. Nucleic Acids Res 44:8908-8920.
  11. Chaliotis A., Vlastaridis P., Mossialos D., Ibba M., Becker H. D., Stathopoulos C. (*) and Amoutzias G. D. (2017) The complex evolutionary history of aminoacyl-tRNA synthetases. Nucleic Acids Res 45:1059-1068.
  12. Stamatopoulou V., Apostolidi M., Li S., Labrinou K., Papakyriakou A., Zhang J. and Stathopoulos C. (2017) Direct modulation of T-box riboswitch controlled transcription by protein synthesis inhibitors. Nucleic Acids Res 45:10242-10258.
  13. Grafanaki K., Anastasakis D., Kyriakopoulos G., Skeparnias I., Georgiou S. and Stathopoulos C. (2019) Translation regulation in skin cancer from a tRNA point of view. Epigenomics 11:215-245. 
  14. Li, S., Su Z., Lehmann J., Stamatopoulou V., Giarimoglou N., Henderson F.E., Fan L., Pintilie G.D., Zhang K., Chen M., Wang Y-X., Stathopoulos C., Chiu W. and Zhang, J. (2019) Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions Nature Stuct Mol Biol 26: 1094-1105.
  15. Skeparnias I., Αnastasakis D., Grafanaki K., Kyriakopoulos G., Alexopoulos P., Dougenis D., Scorilas A., Kontos C. Stathopoulos C. (2020) Contribution of miRNAs, tRNAs and tRFs to aberrant signaling and translation deregulation in lung cancer. Cancers 12:3056.

Selected Presentations

  1. 56th Conference of the Hellenic Society of Biochemistry and Molecular Biology (speaker and member of the organizing committee), 2004.
  2. Department of Biology, University of Athens, Graduate Program on Microbial Sytems, 2005-2009. Department of Chemistry, University of Thessaloniki, Greece, 2005.
  3. Department of Biochemistry, University of Tübingen, Germany.
  4. University of Thessaly, school of Medicine, Graduate Program on primary care, 2005.
  5. Nano2Life 2007 “-omics and Nanotechnology in Biomedicine”, Larissa, Greece.
  6. 5th Annual National Conference on Medical Bio-pathology.
  7. 2nd Symposium on Medical Education, Larissa, Greece. Biotechnology-2011, 1st World Congress in Biotechnology, Hyderbad, India, 2008.
  8. 1st Annual Symposium of Bacteriology and Infection (SBI-2011), Beijing, China, 2010.
  9. 63ο Conference of the Hellenic Society of Biochemistry and Molecular Biology (speaker and session chair), 2012.
  10. Department of Biology, University of Athens, 2013.
  11. Max Plank Institute for Developmental Biology, Tubingnen, Germany, 2015.
  12. MitoCross LabEx, University of Strasbourg, France 2016.

  13. University of Strasbourg, Dept of Molecular Microbiology, Genomics and Genetics, France 2017.

  14. 27th tRNA Conference 23-27 Sept, Strasbourg, France 2018. 

  15. 28th tRNA Conference 31 May- 6 June, Columbus, USA.

PhD Theses Advisor

5 completed, 5 in progress

Other Activities

Editorships

International Journal of Molecular Sciences (IF 4.556) Editorial Board Member, Section: Biochemistry, Molecular and Cellular Biology http://www.mdpi.com/journal/ijms/sectioneditors/biochemistry

Antibiotics (IF 2.446) Editorial Board Member, Section: Mechanisms of Antibiotics Action https://www.mdpi.com/journal/antibiotics/sectioneditors/Mechanisms_Antibiotic_Action

Reviewer for 33 peer-reviewed journals

Reviewer Ad hoc 2019 ELIDEK, 2019 GSRT, 2018 ELIDEK, 2018 Cyrpus Fundation of Reserach and Technology, 2018 ERC, 2017 ELIDEK, 2017 IKY State Scholarships Foundation, PhD applications, 2016 IKY State Scholarships Foundation PhD applications, 2011 IKY State Scholarships Foundation MSc applications, 2010 General Secretariat of Research and Technology, 2009 General Secretariat of Research and Technology, Israeli Research Foundation 2017, ERC Starting Grants 2018, HORIZONS 2020 (IMI) 2020.

Member Ad hoc, 2005-2009 General Exams Committee, Ministry of Education

Administrative positions (recent)

University of Patras Research Committee, Karatheodoris Grants Committee, Member

Institute of Cellular Therapies, University of Patras, Board Member

Director, Postgraduate Program in Biomedical Sciences

Committee for University Service Laboratories, Member

Head, Committee for Academic Quality Assessment, School of Medicine (OMEA)

Member, Committee for Academic Quality Assessment, University of Patras (MODIP)

Vice President, ERASMUS Committee, School of Medicine

Executive director, Unit for Special Biochemical Analyses

ERASMUS+ coordinator, Federal University of Rio de Janeiro, Brazil

ERASMUS coordinator, University of Strasbourg, France

Memberships: The RNA Society; International Society for Infectious Diseases (corresponding member); European Society of Clinical Microbiology and Infectious Diseases; European Protein and Peptides Society; Hellenic Society of Biochemistry and Molecular Biology, Hellenic Society of Biological Sciences; Hellenic Union of Bioscientists; Hellenic Proteomics Society; Hellenic Society of Biotechnology; National Initiative MIKROBIOKOSMOS