GEORGAKOPOULOS CONSTANTINOS, Professor

Department of Ophthalmology, University of Patras, Medical School

+30 210 999286 +30 2610 993994 cgeorg@upatras.gr cgeorg@med.upatras.gr

Office hours

Summary of Curriculum Vitae

Education/Post Doctoral Training: 1984-1990 School of Medicine, University of Patras

1992 -1993 Internship in Surgery and Internal Medicine, Regional Hospital of Mesologi, Greece

1997 -2001 Residency in Ophthalmology, University Hospital of Patras, Greece

Research Fellowships 2000 and 2001 Karolinska Institutet, Stockholm, Sweden

2013 Massachusetts Eye and Ear Infirmary, Boston, USA

Licensure and Certification

1990 Medical School Diploma

March 2000 International Council of Ophthalmology “Basic Science Assessment in Ophthalmology including Optics and Refraction”

March 2001 International Council of Ophthalmology “Clinical Sciences Assessment in Ophthalmology”

August 2001 National Board Certificate in Ophthalmology

Academic /Hospital Appointments:

2002-2008     Lecturer in Ophthalmology, University of Patras, Medical School Attending Physician, Full-Time Faculty, Eye Clinic, University Hospital of Patras

2008-2014     Assistant Professor of Ophthalmology, University of Patras, Medical School

2014-2023     Associate Professor of Ophthalmology, University of Patras, Medical School

 2023             Professor of Ophthalmology, University of Patras, Medical School

2019-2022

and 2024 till now - Head of the Department of Ophthalmology , University Hospital of Patras, Greece                            

                                                             

Professional Societies: Ophthalmological Society of Western Greece (President, 2011-2013)

Hellenic Ophthalmological Society (Member) Greek Glaucoma Society (Member)

Hellenic Society of Intraocular Implant and Refractive Surgery (Member) European Association for Vision and Eye Research (Member)

Research Funding Information 2000-2003 Greek Council of Health Research Fund Grant “Corneal proteoglycans in bacterial ulcers”

2003 Principal Investigator in Greece for Pfizer Corp., Xalaco-0076-036 study “Fixed Combo Xalacom vs Unfixed Combo Xalatan+Timolol”

2003-2006 Research Committee of University of Patras, “Karatheodoris” Research Fund Grant “Biochemical changes of vitreous in experimental endophthalmitis”

2010-2013 Research Committee of University of Patras, “Karatheodoris” Research Fund Grant “The effect of free radicals in cataract formation and apoptosis in retina cells. Possible prevention using natural herbal products”

Undergraduate Courses

• Ophthalmology (Semester: 8th)
• Ophthalmology (Clinical Training) (Semester: 11th & 12th)
• Ophthalmology (Clinical Training - Elective) (Semester: 11th & 12th)

Postgraduate Courses

 MSc "Ocular Surgery" Aristotle University of Thessaloniki

Selected Publications

Makri OE, Tsekouras IK, Mastronikolis SN, Panagiotopoulos VE, Constantoyannis C, Georgakopoulos CD. Terson's Syndrome with Roth Spot-Resembling Features and Third Nerve Palsy without Radiologically Diagnosed Subarachnoid Haemorrhage. Vision (Basel). 2024 Oct 7;8(4):61. doi: 10.3390/vision8040061. PMID: 39449394; PMCID: PMC11503416.

Lykouras M, Papaspyridakou P, Makri OE, Georgakopoulos CD, Orkoula MG. Development of Analytical Method for the Quantitation of Monoclonal Antibodies Solutions via Raman Spectroscopy: The Case of Bevacizumab. Pharmaceuticals (Basel). 2024 Mar 29;17(4):446. doi: 10.3390/ph17040446. PMID: 38675406; PMCID: PMC11055105.

Mastronikolis S, Kagkelaris K, Pagkalou M, Tsiambas E, Plotas P, Georgakopoulos CD. Antioxidant Defense and Pseudoexfoliation Syndrome: An Updated Review. Med Sci (Basel). 2022 Dec 14;10(4):68. doi: 10.3390/medsci10040068. PMID: 36548003; PMCID: PMC9785126.

Mastronikolis S, Tsiambas E, Pagkalou M, Makri OE, Thomopoulou VK, Peschos D, Ragos V, Roukas D, Georgakopoulos CD. c-FOS Expression Analysis in Pterygia Cell Spot Arrays. In Vivo. 2022 Sep-Oct;36(5):2143-2148. doi: 10.21873/invivo.12940. PMID: 36099089; PMCID: PMC9463921.

Kagkelaris K, El Mubarak MA, Plotas P, Panaretos D, Panayiotakopoulos GD, Sivolapenko GB, Georgakopoulos CD. Aqueous Humour Ofloxacin Concentration after Topical Instillation in Patients with Dry Eye Disease. Medicina (Kaunas). 2022 Aug 1;58(8):1031. doi: 10.3390/medicina58081031. PMID: 36013498; PMCID: PMC9414636.

 Makri OE, Tsekouras IK, Leonidou L, Kagkelaris K, Kozobolis V, Georgakopoulos CD. Kyrieleis Arteriolitis Associated with Acute Retinal Necrosis due to Herpes Simplex Virus Type 1 Secondary to Herpetic Encephalitis. Vision (Basel). 2022 May 18;6(2):27. doi: 10.3390/vision6020027. PMID: 35645381; PMCID: PMC9149933.

Mastronikolis S, Pagkalou M, Baroutas G, Kyriakopoulou K, Makri ΟE, Georgakopoulos CD. Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment. IUBMB Life. 2022 Oct;74(10):995-1002. doi: 10.1002/iub.2606. Epub 2022 Feb 24. PMID: 35201654.

Tsapardoni F, Makri OE, Lazaris V, Labropoulou V, Lygeros S, Mastronikolis S, Kouraklis A, Symeonidis A, Georgakopoulos CD. Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population. Clin Ophthalmol. 2020 Dec 24;14:4511-4518. doi: 10.2147/OPTH.S285312. PMID: 33380785; PMCID: PMC7769196.

 Efstathiou NE, Moustafa GA, Maidana DE, Konstantinou EK, Notomi S, Barbisan PRT, Georgakopoulos CD, Miller JW, Vavvas DG. Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. PLoS One. 2020 Dec 23;15(12):e0244307. doi: 10.1371/journal.pone.0244307. PMID: 33362238; PMCID: PMC7757886.

 Georgakopoulos CD, Pallikari A, Plotas P, Kagkelaris K, Mastronikolis S, Plota M, Emmanuil A, Makri OE. Effect of Intravitreal Injection of Aflibercept on Cardiovascular Risk Parameters in Patients with Neovascular Age-Related Macular Degeneration. Curr Rev Clin Exp Pharmacol. 2021;16(3):289-293. doi: 10.2174/1574884715666201016121934. PMID: 33069198.

Makri OE, Pallikari A, Kagkelaris K, Mastronikolis SN, Karanasios G, Symeonidis C, Plotas P, Georgakopoulos CD. The Acute Effects of Electronic Cigarette Vaping and Tobacco Cigarette Smoking on Choroidal Thickness in Young, Healthy, Habitual, Dual Smokers. Toxics. 2020 Oct 11;8(4):85. doi: 10.3390/toxics8040085. PMID: 33050596; PMCID: PMC7712466.

 Georgakopoulos CD, Tsapardoni FN, Makri OE, Vavvas D. TWO-YEAR RESULTS OF INTRAVITREAL INJECTIONS OF AFLIBERCEPT IN COATS DISEASE: A CASE REPORT. Retin Cases Brief Rep. 2022 Jul 1;16(4):473-478. doi: 10.1097/ICB.0000000000001011. PMID: 32541440.

Georgakopoulos CD, Makri OE, Pallikari A, Kagkelaris K, Plotas P, Grammenou V, Emmanuil A. Effect of intravitreal injection of aflibercept on blood coagulation parameters in patients with age-related macular degeneration. Ther Adv Ophthalmol. 2020 Feb 11;12:2515841420903929. doi: 10.1177/2515841420903929. PMID: 32095777; PMCID: PMC7013113.

Makri OE, Tsapardoni FN, Tsekouras IK, Lagogiannis AP, Chairas N, Pallikari A, Pagoulatos DD, Georgakopoulos CD. Visual and anatomic outcomes of aflibercept treatment in treatment-naive patients with neovascular age-related macular degeneration; real-life data over 24 months. Hell J Nucl Med. 2019 Sep-Dec;22 Suppl 2:55-62. PMID: 31802046.

Tsapardoni FN, Makri OE, Lagogiannis AP, Tsekouras IK, Chairas N, Pallikari A, Pagoulatos DD, Georgakopoulos CD. Functional and anatomic results of up to 24 months aflibercept treatment for diabetic macular edema in real-life setting. Hell J Nucl Med. 2019 Sep-Dec;22 Suppl 2:47-54. PMID: 31802045.

 Oikonomakou MZ, Makri OE, Panoutsou E, Kagkelaris K, Plotas P, Garatziotou D, Georgakopoulos CD, Eliopoulou MI. Bacteriology and Antimicrobial Susceptibility Patterns of Childhood Acute Bacterial Conjunctivitis in Western Greece. Med Hypothesis Discov Innov Ophthalmol. 2019 Winter;8(4):266-271. Epub 2019 Oct 1. PMID: 31788487; PMCID: PMC6778672.

 Makri OE, Plotas P, Christopoulou E, Georgakopoulos CD. Effect of a single session of micropulse laser trabeculoplasty on corneal endothelial parameters. Clin Exp Optom. 2020 Jul;103(4):479-483. doi: 10.1111/cxo.12968. Epub 2019 Oct 16. PMID: 31618800.

Makri OE, Pagoulatos D, Kagkelaris K, Plotas P, Georgakopoulos CD. Evaluation of intraocular pressure in the first 24hours after micropulse laser trabeculoplasty in eyes with pseudoexfoliation glaucoma. J Fr Ophtalmol. 2019 Nov;42(9):983-986. doi: 10.1016/j.jfo.2019.05.008. Epub 2019 Jun 6. PMID: 31178072.

 Georgakopoulos CD, Makri OE, Pagoulatos D, Karamanos NK. Expression and Localization of Glycosaminoglycans/Proteoglycan in Pterygium: An Immunohistochemical Study. Med Hypothesis Discov Innov Ophthalmol. 2019 Spring;8(1):39-43. PMID: 30923722; PMCID: PMC6433205.

 Papadopoulou G, Zisimopoulos D, Kalaitzopoulou E, Makri OΕ, Tsapardoni FN, Georgakopoulos CD, Georgiou CD. Age-related aqueous humor (AH) and lens epithelial cell/capsule protein carbonylation and AH protein concentration in cataract patients who have pseudoexfoliative diseases. Mol Vis. 2018 Dec 31;24:890-901. PMID: 30713426; PMCID: PMC6334981.

Georgakopoulos CD, Plotas P, Kagkelaris K, Tsapardoni F, Makri OE. Analgesic Effect of a Single Drop of Nepafenac 0.3% on Pain Associated with Intravitreal Injections: A Randomized Clinical Trial. J Ocul Pharmacol Ther. 2019 Apr;35(3):168-173. doi: 10.1089/jop.2018.0113. Epub 2019 Jan 28. PMID: 30688558.

 Georgakopoulos CD, Plotas P, Angelakis A, Kagkelaris K, Tzouvara E, Makri OE. Dexamethasone implant for immunogammopathy maculopathy associated with IgA multiple myeloma. Ther Adv Ophthalmol. 2019 Jan 8;11:2515841418820441. doi: 10.1177/2515841418820441. PMID: 30671569; PMCID: PMC6329023.

Aletras AJ, Trilivas I, Christopoulou ME, Drakouli S, Georgakopoulos CD, Pharmakakis N. UVB-mediated down-regulation of proteasome in cultured human primary pterygium fibroblasts. BMC Ophthalmol. 2018 Dec 18;18(1):328. doi: 10.1186/s12886-018-0987-8. PMID: 30563490; PMCID: PMC6299496.

Makri OE, Pallikari A, Pagoulatos D, Kagkelaris K, Kostopoulou EV, Georgakopoulos CD. Micropulse laser trabeculoplasty on pseuodexfoliation glaucoma patients under topical prostaglandin analogue monotherapy: 1-year results. Graefes Arch Clin Exp Ophthalmol. 2019 Feb;257(2):349-355. doi: 10.1007/s00417-018-4195-2. Epub 2018 Nov 28. PMID: 30488265.

27: Georgakopoulos CD, Tsapardoni F, Kostopoulou EV, Makri OE. Pattern dystrophies in patients treated with deferoxamine: report of two cases and review of the literature. BMC Ophthalmol. 2018 Sep 12;18(1):246. doi: 10.1186/s12886-018-0911-2. PMID: 30208862; PMCID: PMC6134579.

 Pagoulatos D, Kapsala Z, Makri OE, Georgakopoulos CD. Christmas tree cataract and myotonic dystrophy type 1. Eye (Lond). 2018 Nov;32(11):1794-1795. doi: 10.1038/s41433-018-0161-9. Epub 2018 Jul 9. PMID: 29988074; PMCID: PMC6224496.

Makri OE, Plotas P, Tsapardoni FN, Georgakopoulos CD. Brinzolamide-brimonidine fixed combination to prevent intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy. J Cataract Refract Surg. 2018 Apr;44(4):514-515. doi: 10.1016/j.jcrs.2018.03.006. Epub 2018 Apr 25. PMID: 29705011.

Makri OE, Tsapardoni FN, Plotas P, Aretha D, Georgakopoulos CD. Analgesic Effect of Topical Nepafenac 0.1% on Pain Related to Intravitreal Injections: A Randomized Crossover Study. Curr Eye Res. 2018 Aug;43(8):1061-1064. doi: 10.1080/02713683.2018.1461908. Epub 2018 Apr 16. PMID: 29634375.

Makri OE, Vavvas D, Plotas P, Pallikari A, Georgakopoulos CD. The Effect of Ranibizumab on Normal Neurosensory Retina in the Eyes of Patients with Exudative Age Related Macular Degeneration. Open Ophthalmol J. 2017 Dec 29;11:368-376. doi: 10.2174/1874364101711010368. PMID: 29399233; PMCID: PMC5759102.

Makri OE, Tsapardoni FN, Pagoulatos DD, Pharmakakis N, Georgakopoulos CD. Diclofenac for pain associated with intravitreal injections: a prospective, randomized, placebo-controlled study. Clin Exp Ophthalmol. 2017 Dec;45(9):867-874. doi: 10.1111/ceo.12988. Epub 2017 Jun 30. PMID: 28508561.

 Balasopoulou A, Κokkinos P, Pagoulatos D, Plotas P, Makri OE, Georgakopoulos CD, Vantarakis A. Α molecular epidemiological analysis of adenoviruses from excess conjunctivitis cases. BMC Ophthalmol. 2017 Apr 24;17(1):51. doi: 10.1186/s12886-017-0447-x. PMID: 28438142; PMCID: PMC5404675.

Georgakopoulos CD, Makri OE, Pagoulatos D, Vasilakis P, Peristeropoulou P, Kouli V, Eliopoulou MI, Psachoulia C. Effect of Omega-3 Fatty Acids Dietary Supplementation on Ocular Surface and Tear Film in Diabetic Patients with Dry Eye. J Am Coll Nutr. 2017 Jan;36(1):38-43. doi: 10.1080/07315724.2016.1170643. Epub 2016 Oct 31. PMID: 27797641.

Plotas P, Makri OE, Georgalas I, Pharmakakis N, Vantarakis A, Georgakopoulos CD. Efficacy of Topical Ofloxacin 0.3 % Administration on Conjunctival Bacterial Flora in Diabetic Patients Undergoing Intravitreal Injections. Semin Ophthalmol. 2017;32(6):738-742. doi: 10.3109/08820538.2016.1170165. Epub 2016 Aug 3. PMID: 27487463.

Georgakopoulos CD, Tsapardoni F, Makri OE. EFFECT OF BROMFENAC ON PAIN RELATED TO INTRAVITREAL INJECTIONS: A Randomized Crossover Study. Retina. 2017 Feb;37(2):388-395. doi: 10.1097/IAE.0000000000001137. PMID: 27442130.

 Ferlemi AV, Makri OE, Mermigki PG, Lamari FN, Georgakopoulos CD. Quercetin glycosides and chlorogenic acid in highbush blueberry leaf decoction prevent cataractogenesis in vivo and in vitro: Investigation of the effect on calpains, antioxidant and metal chelating properties. Exp Eye Res. 2016 Apr;145:258-268. doi: 10.1016/j.exer.2016.01.012. Epub 2016 Jan 22. PMID: 26808488.

 Makri OE, Psachoulia C, Exarchou A, Georgakopoulos CD. Intravitreal Ranibizumab as Palliative Therapy for Iris Metastasis Complicated With Refractory Secondary Glaucoma. J Glaucoma. 2016 Jan;25(1):e53-5. doi: 10.1097/IJG.0000000000000163. PMID: 25304284.

Makri OE, Ferlemi AV, Lamari FN, Georgakopoulos CD. Saffron administration prevents selenite-induced cataractogenesis. Mol Vis. 2013 May 30;19:1188-97. PMID: 23734088; PMCID: PMC3669538.

Makri OE, Georgalas I, Georgakopoulos CD. Drug-induced macular edema. Drugs. 2013 Jun;73(8):789-802. doi: 10.1007/s40265-013-0055-x. PMID: 23640687.

Georgakopoulos CD, Makri OE, Plotas P, Pharmakakis N. Brinzolamide-timolol fixed combination for the prevention of intraocular pressure elevation after phacoemulsification. Clin Exp Ophthalmol. 2013 Sep-Oct;41(7):662-7. doi: 10.1111/ceo.12092. Epub 2013 Apr 11. PMID: 23432730.

 Georgakopoulos CD, Makri OE, Vasilakis P, Exarchou A. Angiographically silent cystoid macular oedema secondary to paclitaxel therapy. Clin Exp Optom. 2012 Mar;95(2):233-6. doi: 10.1111/j.1444-0938.2011.00672.x. Epub 2011 Oct 25. PMID: 22023333.

 Pharmakakis N, Giannopoulos K, Stasinos S, Makri OE, Georgakopoulos CD. Effect of a fixed brimonidine-timolol combination on intraocular pressure after phacoemulsification. J Cataract Refract Surg. 2011 Feb;37(2):279-83. doi: 10.1016/j.jcrs.2010.08.046. PMID: 21241910.

Georgakopoulos CD, Eliopoulou MI, Stasinos S, Exarchou A, Pharmakakis N, Varvarigou A. Periorbital and orbital cellulitis: a 10-year review of hospitalized children. Eur J Ophthalmol. 2010 Nov-Dec;20(6):1066-72. doi: 10.1177/112067211002000607. PMID: 20544674.

 Georgakopoulos CD, Eliopoulou MI, Exarchou AM, Tzimis V, Pharmakakis NM, Spiliotis BE. Decreased contrast sensitivity in children and adolescents with type 1 diabetes mellitus. J Pediatr Ophthalmol Strabismus. 2011 Mar- Apr;48(2):92-7. doi: 10.3928/01913913-20100420-02. Epub 2010 Apr 22. PMID: 20438040.

Georgakopoulos CD, Lamari FN, Karathanasopoulou IN, Gartaganis VS, Pharmakakis NM, Karamanos NK. Tear analysis of ascorbic acid, uric acid and malondialdehyde with capillary electrophoresis. Biomed Chromatogr. 2010 Aug;24(8):852-7. doi: 10.1002/bmc.1376. PMID: 20024890.

 Pharmakakis NM, Petropoulos IK, Georgakopoulos CD, Vantzou CV, Anastassiou ED, Mavropoulos A, Zolota V. Apoptotic mechanisms within the retina in Staphylococcus epidermidis experimental endophthalmitis. Graefes Arch Clin Exp Ophthalmol. 2009 May;247(5):667-74. doi: 10.1007/s00417-008-0996-z. Epub 2008 Nov 28. PMID: 19039600.

Georgakopoulos CD, Exarchou AM, Gartaganis SP, Kolonitsiou F, Anastassiou ED, Dimitracopoulos G, Hjerpe A, Theocharis AD, Karamanos NK. Immunization with specific polysaccharide antigen reduces alterations in corneal proteoglycans during experimental slime-producing Staphylococcus epidermidis keratitis. Curr Eye Res. 2006 Feb;31(2):137-46. doi: 10.1080/02713680500516540. PMID: 16500764.

 Assouti M, Vynios DH, Anagnostides ST, Papadopoulos G, Georgakopoulos CD, Gartaganis SP. Collagen type IX and HNK-1 epitope in tears of patients with pseudoexfoliation syndrome. Biochim Biophys Acta. 2006 Jan;1762(1):54-8. doi: 10.1016/j.bbadis.2005.09.005. Epub 2005 Oct 11. PMID: 16257185.

Gartaganis SP, Georgakopoulos CD, Patsoukis NE, Gotsis SS, Gartaganis VS, Georgiou CD. Glutathione and lipid peroxide changes in pseudoexfoliation syndrome. Curr Eye Res. 2005 Aug;30(8):647-51. doi: 10.1080/02713680590968367. PMID: 16109644.

 Gartaganis SP, Georgakopoulos CD, Assouti M, Mela EK, Exarchou A, Giannelou I, Gotsis SS, Ziouti N, Vynios DH, Tripathi BJ, Tripathi RC. Changes in HNK-1 epitope and collagen type IX in the aqueous humour of patients with pseudoexfoliation syndrome. Curr Eye Res. 2004 Jan;28(1):5-10. doi: 10.1076/ceyr.28.1.5.23490. PMID: 14704908.

Gartaganis SP, Georgakopoulos CD, Exarchou A, Mela EK, Psachoulia C, Eliopoulou MI, Kourakli A, Gotsis SS, Tripathi RC. Alterations in conjunctival cytology and tear film dysfunction in patients with beta-thalassemia. Cornea. 2003 Oct;22(7):591-7. doi: 10.1097/00003226-200310000-00002. PMID: 14508254.

Mela EK, Georgakopoulos CD, Georgalis A, Koliopoulos JX, Gartaganis SP. Severe ocular injuries in Greek children. Ophthalmic Epidemiol. 2003 Feb;10(1):23-9. doi: 10.1076/opep.10.1.23.13771. PMID: 12607156.

Gartaganis SP, Georgakopoulos CD, Mela EK, Exarchou A, Ziouti N, Assouti M, Vynios DH. Matrix metalloproteinases and their inhibitors in exfoliation syndrome. Ophthalmic Res. 2002 May-Jun;34(3):165-71. doi: 10.1159/000063661. PMID: 12097800.

Georgakopoulos CD, Exarchou A, Koliopoulos JX, Gartaganis SP, Anastassiou ED, Kolonitsiou F, Lamari F, Karamanos NK, Dimitracopoulos G. Levels of specific antibodies towards the major antigenic determinant of slime-producing Staphylococcus epidermidis determined by an enzyme immunoassay and their protective effect in experimental keratitis. J Pharm Biomed Anal. 2002 Jun 20;29(1-2):255-62. doi: 10.1016/s0731-7085(02)00056-0. PMID: 12062685.

Gartaganis SP, Georgakopoulos CD, Exarchou AM, Mela EK, Lamari F, Karamanos NK. Increased aqueous humor basic fibroblast growth factor and hyaluronan levels in relation to the exfoliation syndrome and exfoliative glaucoma. Acta Ophthalmol Scand. 2001 Dec;79(6):572-5. doi: 10.1034/j.1600-0420.2001.790605.x. PMID: 11782221.