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Papafaklis Michail, Assistant Professor

Papafaklis Michail

Sector: Division of Internal Medicine Ι

Clinic/Laboratory: Department of Internal Medicine

Knowledge Subject: Cardiology - Interventional Cardiology

Research Area: percutaneous coronary intervention; stents; fractional flow reserve; intravascular ultrasound; optical coherence tomography; hemodynamics; shear stress; invasive and non-invasive three-dimensional (3D) imaging of coronary arteries; biomedical engineering in the cardiovascular system; survival studies following percutaneous coronary interventions; pathophysiology and molecular mechanisms of atherosclerosis (coronary artery disease and carotids)

University Hospital of Patras (office 1.12 - 1st floor)

2613603936, 6944376572 mpapafaklis@upatras.gr

Office hours

Tuesday 12.00-14.00

Summary of Curriculum Vitae

Michail (Michael) I. Papafaklis, M.D., Ph.D., FESC is an Interventional Cardiologist and currently works as Assistant Professor of Medicine - Interventional Cardiology at the Medical School, University of Patras and the University Hospital of Patras.

Dr Papafaklis received his MD degree and also his PhD diploma from the Medical School of the University of Ioannina. He completed his Cardiology training at the University Hospital of Ioannina. He has been trained in Interventional Cardiology at Barts Heart Centre, St Bartholomew's Hospital in London, UK, and is fully certified in Interventional Cardiology by the European Association of Percutaneous Coronary Intervention (EAPCI) and the Hellenic Ministry of Health. His primary clinical expertise in interventional cardiology includes the assessment of coronary physiology, intracoronary imaging with intravascular ultrasound and optical coherence tomography, and complex high-risk indicated percutaneous coronary intervention (CHIP-PCI).

Dr Papafaklis has worked as a Postdoctoral Research Fellow at the Brigham and Women's Hospital, Harvard Medical School and Massachusetts Institute of Technology in USA, and he joined the George D. Behrakis Cardiovascular Research Fellowship in 2011. In the past, he also was a visiting scientist in the Interventional Department of the Thoraxcenter, Erasmus MC in the Netherlands.

Dr Papafaklis has authored more than 110 peer-reviewed papers and he has presented several abstracts in international cardiology conferences. He was the winner of the distinguished Young Investigator Award by the European Society of Cardiology in 2011, and he has received awards from the Academy of Athens and the Hellenic Cardiological Society.

Undergraduate Courses

Selected Publications

PUBLICATION & CITATIONS Mini Summary
Peer-reviewed full-text publications: 119
Citations: > 4500 (Source: SCOPUS Database; Elsevier)
h-index: 33

Key Full-text Publications (from a total of 119 publications)

  1. Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Raber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK. Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol 2022 Apr 21. doi: 10.1038/s41569-022-00687-9. Online ahead of print.
  2. Wentzel JJ, Papafaklis MI, Antoniadis AP, Takahashi S, Cefalo NV, Cormier M, Saito S, Coskun AU, Stone PH. Sex-related differences in plaque characteristics and endothelial shear stress related plaque-progression in human coronary arteries. Atherosclerosis 2021 Dec;342:9-18.
  3. Sakellariou XM, Papafaklis MI*, Domouzoglou EM, Katsouras CS, Michalis LK, Naka KK. Exercise-mediated adaptations in vascular function and structure: Beneficial effects in coronary artery disease. World J Cardiol 2021 Sep;13(9):399-416. *Corresponding author
  4. Papafaklis MI, Katsouras CS, Tsigkas G, Toutouzas K, Davlouros P, Hahalis GN, Kousta MS, Styliadis IG, Triantafyllou K, Pappas L, Tsiourantani F, Varytimiadi E, Anyfantakis ZA, Iakovis N, Grammata P, Karvounis H, Ziakas A, Sianos G, Tziakas D, Pappa E, Dagre A, Patsilinakos S, Trikas A, Lamprou T, Mamarelis I, Katsimagklis G, Karmpaliotis D, Naka K, Michalis LK. "Missing" acute coronary syndrome hospitalizations during the COVID-19 era in Greece: Medical care avoidance combined with a true reduction in incidence? Clin Cardiol 2020 Oct;43(10):1142-9.
  5. Anagnostopoulos CD, Siogkas PK, Liga R, Benetos G, Maaniitty T, Sakellarios AI, Koutagiar I, Karakitsios I, Papafaklis MI, Berti V, Sciagra R, Scholte A, Michalis LK, Gaemperli O, Kaufmann PA, Pelosi G, Parodi O, Knuuti J, Fotiadis DI, Neglia D. Characterization of functionally significant coronary artery disease by a coronary computed tomography angiography-based index: a comparison with positron emission tomography. Eur Heart J Cardiovasc Imaging 2019 Aug;20(8):897-905.
  6. Papafaklis MI, Baumbach A. From Lumenogram to "Functional Angiography" and the Evolution of Virtual Fractional Flow Reserve. Circulation 2019;139(4):485-8.
  7. Papafaklis MI, Mavrogiannis MC, Siogkas PK, Lakkas LS, Katsouras CS, Fotiadis DI, Michalis LK. Functional assessment of lesion severity without using the pressure wire: Coronary imaging and blood flow simulation. Expert Rev Cardiovasc Ther 2017 Nov;15(11):863-77.
  8. Karanasiou GS, Papafaklis MI, Conway C, Michalis LK, Tzafriri R, Edelman ER, Fotiadis DI. Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling. Ann Biomed Eng 2017 Apr;45(4):853-72.
  9. Papafaklis MI. Characterizing the hyperemia-induced mechanical stress acting on the plaque. J Am Coll Cardiol Img 2016 Jun;9(6):760-1.
  10. Papafaklis MI*, Mavrogiannis MC, Michalis LK. Prolonged dual antiplatelet therapy: a potential mitigator of the adverse effects of local haemodynamic shear stress in high-risk coronary regions? EuroIntervention 2016 Feb;11(11):e1218-20. *Corresponding Author
  11. Papafaklis MI, Mizuno S, Takahashi S, Coskun AU, Antoniadis AP, Tsuda M, Feldman CL, Saito S, Stone PH. Incremental predictive value of combined endothelial shear stress, plaque necrotic core, and plaque burden for future cardiac events: A post-hoc analysis of the PREDICTION study. Int J Cardiol 2016 Jan 1;202:64-6.
  12. Kotsia AP, Papafaklis MI, Michael TT, Rangan BV, Peltz M, Roesle M, Jessen M, Willis B, Christopoulos G, Nakas G, Giannitsi S, Michalis LK, Fotiadis DI, Banerjee S, Brilakis ES. Serial Multimodality Evaluation of Aortocoronary Bypass Grafts During the First Year After CABG Surgery. J Am Coll Cardiol Img 2015 Nov;8(11):1341-3.
  13. Papafaklis MI, Bourantas CV, Yonetsu T, Vergallo R, Kotsia A, Nakatani S, Lakkas LS, Athanasiou LS, Naka KK, Fotiadis DI, Feldman CL, Stone PH, Serruys PW, Jang IK, Michalis LK. Anatomically correct three-dimensional coronary artery reconstruction using frequency domain optical coherence tomographic and angiographic data: head-to-head comparison with intravascular ultrasound for endothelial shear stress assessment in humans. EuroIntervention 2015 Aug;11(4):407-15.
  14. Papafaklis MI, Takahashi S, Antoniadis AP, Coskun AU, Tsuda M, Mizuno S, Andreou I, Nakamura S, Makita Y, Hirohata A, Saito S, Feldman CL, Stone PH. Effect of the local hemodynamic environment on the de novo development and progression of eccentric coronary atherosclerosis in humans: insights from PREDICTION. Atherosclerosis 2015 May;240(1):205-11.
  15. Vergallo R*, Papafaklis MI*, Yonetsu T, Bourantas CV, Andreou I, Wang Z, Fujimoto JG, McNulty I, Lee H, Biasucci LM, Crea F, Feldman CL, Michalis LK, Stone PH, Jang IK. Endothelial shear stress and coronary plaque characteristics in humans: combined frequency-domain optical coherence tomography and computational fluid dynamics study. Circ Cardiovasc Imaging 2014 Nov;7(6):905-11. *First equal author
  16. Papafaklis MI, Muramatsu T, Ishibashi Y, Lakkas LS, Nakatani S, Bourantas CV, Ligthart J, Onuma Y, Echavarria-Pinto M, Tsirka G, Kotsia A, Nikas DN, Mogabgab O, van Geuns RJ, Naka KK, Fotiadis DI, Brilakis ES, Garcia-Garcia HM, Escaned J, Zijlstra F, Michalis LK, Serruys PW. Fast virtual functional assessment of intermediate coronary lesions using routine angiographic data and blood flow simulation in humans: comparison with pressure wire - fractional flow reserve. EuroIntervention 2014 Sep;10(5):574-83.
  17. Bourantas CV, Papafaklis MI, Kotsia A, Farooq V, Muramatsu T, Gomez-Lara J, Zhang YJ, Iqbal J, Kalatzis FG, Naka KK, Fotiadis DI, Dorange C, Wang J, Rapoza R, Garcia-Garcia HM, Onuma Y, Michalis LK, Serruys PW. Effect of the endothelial shear stress patterns on neointimal proliferation following drug-eluting bioresorbable vascular scaffold implantation: an optical coherence tomography study. JACC Cardiovasc Interv 2014 Mar;7(3):315-24.
  18. Bourantas CV*, Papafaklis MI*, Lakkas L, Sakellarios A, Onuma Y, Zhang YJ, Muramatsu T, Diletti R, Bizopoulos P, Kalatzis F, Naka KK, Fotiadis DI, Wang J, Garcia Garcia HM, Kimura T, Michalis LK, Serruys PW. Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived reconstructions. Int J Cardiovasc Imaging 2014 Mar;30(3):485-94. *First equal author
  19. Papafaklis MI, Bourantas CV, Farooq V, Diletti R, Muramatsu T, Zhang Y, Fotiadis DI, Onuma Y, Garcia Garcia HM, Michalis LK, Serruys PW. In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography. EuroIntervention 2013 Nov;9(7):890.
  20. Sakellarios AI, Papafaklis MI, Siogkas P, Athanasiou LS, Exarchos TP, Stefanou K, Bourantas CV, Naka KK, Michalis LK, Parodi O, Fotiadis DI. Patient-specific computational modeling of subendothelial LDL accumulation in a stenosed right coronary artery: effect of hemodynamic and biological factors. Am J Physiol Heart Circ Physiol 2013 Jun;304(11):H1455-70.
  21. Bourantas CV*, Papafaklis MI*, Athanasiou L, Kalatzis FG, Naka KK, Siogkas PK, Takahashi S, Saito S, Fotiadis DI, Feldman CL, Stone PH, Michalis LK. A New Methodology for Accurate 3-dimensional Coronary Artery Reconstruction Using Routine Intravascular Ultrasound and Angiographic Data: Implications for Widespread Assessment of Endothelial Shear Stress in Humans. EuroIntervention 2013 Sep;9(5):582-93. *First equal author
  22. Stone PH, Saito S, Takahashi S, Makita Y, Nakamura S, Kawasaki T, Takahashi A, Katsuki T, Nakamura S, Namiki A, Hirohata A, Matsumura T, Yamazaki S, Yokoi H, Tanaka S, Otsuji S, Yoshimachi F, Honye J, Harwood D, Reitman M, Coskun AU, Papafaklis MI, Feldman CL. Prediction of Progression of Coronary Artery Disease and Clinical Outcomes Using Vascular Profiling of Endothelial Shear Stress and Arterial Plaque Characteristics: The PREDICTION Study. Circulation 2012 Jul;126(2):172-81.
  23. Papafaklis MI*, Chatzizisis YS, Naka KK, Giannoglou GD, Michalis LK. Drug-eluting stent restenosis: effect of drug type, release kinetics, hemodynamics and coating strategy. Pharmacol Ther 2012 Apr;134(1):43-53. *Corresponding author
  24. Papafaklis MI, Koskinas KC, Chatzizisis YS, Stone PH, Feldman CL. In-vivo assessment of the natural history of coronary atherosclerosis: vascular remodeling and endothelial shear stress determine the complexity of atherosclerotic disease progression. Curr Opin Cardiol 2010 Nov;25(6):627-38.
  25. Papafaklis MI, Bourantas CV, Theodorakis PE, Katsouras CS, Naka KK, Fotiadis DI, Michalis LK. The effect of shear stress on neointimal response following sirolimus- and paclitaxel-eluting stent implantation compared to bare metal stents in humans. J Am Coll Cardiol Intv 2010 Nov;3(11):1181-9.
  26. Papafaklis MI, Bourantas CV, Theodorakis PE, Katsouras CS, Fotiadis DI, Michalis LK. Relationship of shear stress with in-stent restenosis: bare metal stenting and the effect of brachytherapy. Int J Cardiol 2009 May;134(1):25-32.
  27. Sianos G, Papafaklis MI, Daemen J, Vaina S, van Mieghem CA, van Domburg RT, Michalis LK, Serruys PW. Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infarction: the importance of thrombus burden. J Am Coll Cardiol 2007 Aug;50(7):573-583.
  28. Papafaklis MI, Naka KK, Papamichael ND, Kolios G, Sioros L, Sclerou V, Katsouras CS, Michalis LK. The impact of renal function on the long-term clinical course of patients who underwent percutaneous coronary intervention. Catheter Cardiovasc Interv 2007 Feb;69(2):189-97.
  29. Papafaklis MI, Sianos G, Cost B, Vaina S, Manginas A, Dardas P, Tsikaderis D, Van Mieghem CA, Michalis LK, Serruys PW. Clinical and angiographic follow-up after overlapping implantation of polytetrafluoethylene covered stents with drug eluting stents. EuroIntervention 2006 Aug;2:218-223.