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Personel - TSOPANOGLOU NI.

TSOPANOGLOU NIKOS, Professor

TSOPANOGLOU NIKOS

Sector: Division of Basic Medical Sciences II

Clinic/Laboratory: Department of General Pharmacology

Knowledge Subject: Pharmacology

Research Area: Thrombin and its receptor, PAR1, as novel pharmacological targets for the development of new agents in the treatment of cardiovascular diseases

Department of Pharmacology, Medical School, Builting of Preclinical Activities, University of Patras, 26504 Rio-Patras, Greece Third Level, East Section

+30-2610-996171 +30-2610-994720 ntsopan@med.upatras.gr

Download Curriculum Vitae

Summary of Curriculum Vitae

Dr. Nikos E. Tsopanoglou is Associate Professor of Pharmacology with long experience in the field of angiogenesis. For more than twenty years, his research interests focus on the role of thrombin and its receptor, PAR1, in angiogenesis. He was the first reported that thrombin is a potent activator of angiogenesis.  More recently, he has discovered the potential biological roles for parstatin, the peptide released upon the activation of PAR1 by thrombin. He has shown that parstatin exerts potent anti-angiogenic effects and provide protection to myocardium and kidneys against ischemia and reperfusion injury. He has established an extended network of collaborators in Greece, Europe and the USA. His research activities were supported by several research grants from University of Patras, Greek Secretary of Research and Technology, Greek Ministry of Education as well as private pharmaceutical and biotech companies.  He has published 31 research papers in peer-reviewed journals (mean IF: 3.718; citations: >1000; h-index:18), has edited 2 books and 33 abstract in National and International lournals. Also, he has filed 7 patent applications and he has supervised 16 Msc thesis and 5 PhD thesis. He has reviewed numerous manuscripts for publication for many scientific journals and he has served as research grant reviewer for France, Portuguese and Greek Science and Technology Foundations. Recently, Dr. Tsopanoglou is co-founder of spin-off company AngioLogic LLC.  

Undergraduate Courses

Postgraduate Courses

  • Ερευνητικά Θέματα (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Εργαστηριακή Εκπαίδευση I (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Μεθοδολογία της έρευνας στις Βασικές Ιατρικές Επιστήμες II (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Ανάλυση Τρέχουσας Βιβλιογραφίας (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Εργαστηριακή Εκπαίδευση II (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Φαρμακοκινητική – Τοξικολογία (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Παρουσίαση Αποτελεσμάτων (ΠΜΣ - Βασικών Ιατρικών Επιστημών)

Selected Publications

  1. Tsopanoglou NE, Pipilli-Synetos E, and Maragoudakis ME. Thrombin promotes angiogenesis by a mechanism independent of fibrin formation. American Journal of Physiology-Cell Physiology, 1993; 264: C1302-C1307.
  2. Tsopanoglou NE, and Maragoudakis ME. On the mechanism of thrombin-induced angiogenesis: Potentiation of vascular endothelial growth factor activity on endothelial cells by upregulation of its receptors. Journal of Biological Chemistry, 1999; 274: 23969-23976.
  3. Tsopanoglou NE, Andriopoulou P, and Maragoudakis, NE. On the mechanism of thrombin-induced angiogenesis: Involvement of ανβ3 integrin. American Journal of Physiology-Cell Physiology, 2002; 283: C1501-C1510.
  4. Tsopanoglou NE, and Maragoudakis ME. Role of thrombin and its receptors in angiogenesis and tumor progression. Seminars in Thrombosis and Haemostasis, 2004; 30: 63-69.
  5. Papaconstantinou M, Carrell CJ, Pineda AO, Bobofchak KE, Mathews FS, Flordellis SC, Maragoudakis ME, Tsopanoglou NE*, and Di Cera E. Thrombin functions through its RGD sequence in a non-canonical conformation. Journal Biological Chemistry (Accelerated Publication), 2005; 280: 29393-29396.
  6. Zania P, Kritikou S, Flordellis CS, Maragoudakis ME, and Tsopanoglou NE. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1 (PAR-1): Association with endothelial cell growth suppression and induction of apoptosis. Journal of Pharmacology and Experimental Therapeutics, 2006, 318: 246-254.
  7. 21. Zania P, Gourni D, Aplin AC, Nicosia RF, Flordellis SC, Maragoudakis ME, and Tsopanoglou NE. Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis. Journal of Pharmacology and Experimental Therapeutics, 2009, 328: 378-389.
  8. Katsanos K, Karnabatidis D, Diamantopoulos A, Kagadis GC, Ravazoula P, Nikiforidis GC, Siablis D, and Tsopanoglou NE. Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model. Journal of Vascular Surgery, 2009, 49: 1000-1012.
  9. Routhu KV, Tsopanoglou NE, and Strande JL. Parstatin (1-26): The putative signal peptide of PAR1 confers potent protection from myocardial ischemia-reperfusion injury. Journal of Pharmacology and Experimental Therapeutics, 2010, 332: 898-905.
  10. Huang H, Vasilakis P, Zhong X, Shen J-K, Geronatsiou K, Papadaki H, Maragoudakis ME, Gartaganis SP, Vinores SA and Tsopanoglou NE.* Parstatin suppresses ocular neovascularization and inflammation. Investigative Ophthalmology & Visual Science, 2010, 51: 5825-5832.
  11. Zampatis ED, Rutz C, Furkert J, Schmidt A, Wüstenhagen D, Kubick S, Tsopanoglou NE* and Schülein R. The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression. FEBS Letters, 2012, 586: 2351-2359.
  12. Diamantopoulos A, Kyriazis I, Geronatsiou K, Papadaki H, Loudos G, Kagadis G, Katsanos K, Liatsikos E, Karnabatidis D, Siamblis D, and Tsopanoglou NE.* Parstatin prevents renal injury following ischemia/reperfusion and radiocontrast administration. American Journal of Nephrology, 2012, 36: 278-286
  13. Ventosa-Andres P, Valdivielso AM, Pappos I, Garcia-Lopez MT, Tsopanoglou NE, and Herranz R. Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1. European Journal of  Medicinal Chemistry, 2012, 58: 98-111.
  14. Karatzas A, Katsanos K, Lilis I, Papadaki H, Panagiotis Kitrou P, Lecht S, Marcinkiewicz C, Siablis D, Lelkes PI, Lazarovici P, and Tsopanoglou NE*. NGF promotes hemodynamic recovery in a rabbit hindlimb ischemic model through trkA- and VEGFR2-dependent pathways. Journal of Cardiovascular Pharmacology , 2013. (in press)

Selected Presentations

• 8th International Conference on Angiogenesis: Basic Science and Clinical Applications, Chandris Hotel, Corfu, Greece, June, 2006.
• 5th General Meeting of the International Proteolysis Society, Conference and Cultural Center, University of Patras, October, 2007.
• 9th International Conference on Angiogenesis: Basic Science and Clinical Applications, Conference and Cultural Center, University of Patras, June, 2008.
• Leibniz-Institut fur Molekulare Pharmakologie (FMP), Berlin, Germany, February, 2009.
• 14th  Hellenic Pharmacy Conference, Conference Center of Athens, May 2009.
• 6th  Hellenic Pharmacology Conference, Heraklion, Crete, June 2010.
• ISER 2012, XX Biennial Meeting of the International Society for Eye Research, Berlin, Germany, July 21-25, 2012.

PhD Theses Advisor

  1. Matthew Papaconstantinou. "Functional and biological role of RGD sequence of thrombin" (2005)
  2. Panagiota Zania. Thrombin and its receptor, PAR1, as targets for the development of new agents for the treatment of angiogenesis-related diseases. (2007)
  3. Konstantinos Katsanos. "Investigation of angiogenic and arteriogenic effects of thrombin in rabbit hind-limb ischemia model". (2009)
  4. Sotiria Kefala. "Studies on the mechanism of action of parstatin 1-26" (in progress)

Other Activities

Honors
1989-1990  University of Patras, Academic Scholarship for Graduate Studies
1990-1993  National Scholarship Foundation for Graduate Studies
1997-1999  National Scholarship Foundation for Postdoctoral Research
2002-2004  Member, Scientific Council for Drugs Approval, National Drug Organization
 
Reviewer for the Journals

- Archives of Medical Research
- Archives in Pharmacology
- Apoptosis
- Blood
- British Journal of Pharmacology
- Current Medicinal Chemistry
- Experimental Neurology
- In Vitro Cellular & Developmental Biology – Animal
- Investigative Ophthalmology & Visual Science
- Journal of Cellular and Molecular Medicine
- Journal of the Neurological Sciences
- Journal of Thrombosis and Hemostasis
- Molecular and Cellular Biochemistry
- Molecular Pharmacology
- Oncogene
- Vascular Pharmacology

 
Reviewer for the Research Grants

• External expert reviewer for research proposal submitted to Portuguese Science and Technology Foundation (FCT)

• External expert reviewer for research proposal submitted to French National Research Agency (ANR)

• External expert reviewer for research proposal submitted to Greek National Research Agency (GSRT)