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Personel - Zarkadis Nt.

Zarkadis Ntouros Ioannis, Professor

Zarkadis Ntouros Ioannis

Sector: Division of Basic Medical Sciences I

Clinic/Laboratory: Department of General Biology

Knowledge Subject:

Research Area: Studies on complement system: molecular evolution in the teleost level, complement genes and human diseases. Molecular and functional studies on Hyper-gE syndrome. Molecular identification of microorganisms in Greek patients

Department of General Biology,School of Medicine,University of Patras,Rion,26500, Hellas 3nd, east wing

+30 2610 997612 +30 2610 991769

Download Curriculum Vitae

Summary of Curriculum Vitae

B.Sc.Natural Sciences (Chemistry), University of Patras (1980),
Ph.D. Molecular Biology, School of Medicine University of Patras (1990).
Research training, Institute of Molecular Biology Biotechnology, Crete, (1987-1989). FEBS Short Fellowship  to Hubrecht Laboratory, Utrecht, The Netherlands (1989). EMBO Short Fellowship  to University of Newcastle,UK (1993). Sabbatical to Departments of Ob/Gynecology and Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA (1994-1995), and visits of 2 months (1996, 2000, 2004). Visit for research collaboration to Institut de Biologia Fundamental, Autonome  University of Barcelona,
Spain (1998).
More than 25 years of undergraduate teaching experience/laboratory training in Biology to medical and Pharmacy School students, Patras University. 20 years of teaching in several postgraduate Courses (Basic Medical Sciences, Clinical and Laboratory Medicine and Informatics of Life Sciences). Assigned supervisor for (5) doctoral theses and (12) M.Sc. theses of the postgraduate course in Basic Medical Sciences and Informatics of Life Sciences. Member in (32) advisory committees for doctorates and M.Sc. Examiner in (10) doctorate examination committees. Member of 7 Scientific Societies. Reviewer in 11 international scientific journals. Financing of 6 research grants (P.I).
Studies on complement system: molecular evolution in the teleost level, complement genes and human diseases. Molecular and functional studies on Hyper-gE syndrome. Molecular identification of microorganisms in Greek patients.
Full-papers in International Journals: 45.  More than 600 citations. Abstracts in International Conferences: 34. Abstracts in Hellenic Conferences: 38. Direct submissions of nucleotide and amino-acid sequences in GenBank/EMBL: 65

Undergraduate Courses

Postgraduate Courses

  • ΠΒ1. Αρχές Μοριακής Βιολογίας και Γενετικής (ΔΠΜΣ ΠΕΖ)
  • Εισαγωγή στη Βιοπληροφορική (ΔΠΜΣ ΠΕΖ)
  • Μεθοδολογία της έρευνας στις Βασικές Ιατρικές Επιστήμες I (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Ερευνητικά Θέματα (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Πληροφορική της Βιοϊατρικής Έρευνας (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Εισαγωγή στη Μοριακή και Κυτταρική Βιολογία (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Εργαστηριακή Εκπαίδευση I (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Τρέχοντα Θέματα Βιολογικής Έρευνας (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Ανάλυση Τρέχουσας Βιβλιογραφίας (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Εργαστηριακή Εκπαίδευση II (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Μοριακή Γενετική – Κυτταρογενετική (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Σεμινάρια Φοιτητών Ι (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Σεμινάρια Φοιτητών ΙΙ (ΠΜΣ - Βασικών Ιατρικών Επιστημών)
  • Μοριακή Βιολογία και Στοιχεία Μοριακής Ιατρικής (ΠΜΣ - ΚΚΙΕ)
  • Ιατρική Πληροφορική (ΠΜΣ - ΚΚΙΕ)

Selected Publications

  1. Sunyer J.O., Zarkadis IK., Lambris J.D. Multiple forms of Complement C3 in Trout that differ in binding to complement activators. Proc. Natl. Acad. Sci. USA, (1996) 93:8546-8551.
  2. Zarkadis IK., Vezyri E., Kouvelas E., Thanos D., Papamattheakis I. and Athanassiadou A. cDNA cloning of the translocon associated protein β-subunit in the chick cerebellum. Gene, (1997) 201:1-4.
  3. Sunyer J.O., Zarkadis I.K., and Lambris J.D. Complement diversity: a mechanism for generating immune diversity? Immunology Today, (1998) 19(11): 519-523.
  4. Sunyer J.O., Zarkadis IK., Sarrias M.R., Lambris J.D. Cloning of two rainbow trout Bf/C2 complement molecules and characterization of an ancestral Bf/C2 molecule having both factor B and C2 functions. J.Immunology, (1998) 161(8): 4106-4114.
  5. Del Rio-Tsonis, Tsonis A., Zarkadis IK., Tsangas A.G. and Lambris J.D. Expression of the third component of complement C3, in regenerating limb blastema cells of urodeles. J.Immunology, (1998) 161(12): 6819-6824.
  6. Papanastasiou AD, and Zarkadis IK. Gene duplication of the seventh component of complement in rainbow trout. Immunogenetics. (2005)57(9):703-708
  7. Papanastasiou AD and Zarkadis IK. Cloning and phylogenetic analysis of the alpha subunit of the eighth complement component (C8) in rainbow trout. Molecular Immunology (2006) 43(14):2188-2194
  8. Papanastasiou AD, Georgaka E, and Zarkadis IK. Cloning of a CD59-like gene in rainbow trout. Expression and phylogenetic analysis of two isoforms. Molecular Immunology. (2006) 44(6):1300-1306.
  9. Georgaka Eleftheria, Nastopoulos Vassilios, Eleftheriou Sofia and IK Zarkadis Τoxin-like gene in rainbow trout: cloning, expression, and gene organization. Toxicon (2007) 49 (7): 1002-1009.
  10. G. B. Christakis, P. Alexaki, A. S. Alivizatos, A. E. Athanasiou and IK Zarkadis. Primary bacteremia caused by Rhizobium radiobacter in a patient with solid tumor. Journal of Medical Microbiology. (2006) 55:1453-1456.
  11. Londou A, Mikrou A, Zarkadis IK Cloning and characterization of two clusterin isoforms in rainbow trout. Molecular Immunology. (2008) 45(2):470-478.
  12. Chondrou M, Papanastasiou AD, Spyroulias GA, Zarkadis IK. Three isoforms of complement properdin factor P in trout: Cloning, expression, gene organization and constrained modeling. Dev Comp Immunology. (2008) 32(12):1454-1466.
  13. Giannakopoulos A, Stavrou EF, Zarkadis I, Zoumbos N, Thrasher AJ, Athanassiadou A. The functional role of S/MARs in episomal vectors as defined by the stress-induced destabilization profile of the vector sequences. J Mol Biol. (2009) 387(5):1239-1249.
  14. Marioli DI, Pharmakakis N, Deli A, Havvas I, Zarkadis IK. Complement factor H and LOC387715 gene polymorphisms in a Greek population with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. (2009) 247:1547-1553.
  15. Papanastasiou AD, Mantagos S, Papanastasiou DA, Zarkadis IK. A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome. Mol Immunol. (2010) 47: 1629-1634.

PhD Theses Advisor

  1. Study of a new mutation in STAT3 gene, witch is involved in the Hyper-IgE immunodeficiency syndrome. Anastasios Papanastasiou (2010)