Clinical Pharmacology and Toxicology
Semester 5th ()
Hours 2
Teachers
Description
- ECTS Credits
- 4
- Course Type
- Scientific field
- Prerequisite Courses
- Pharmacology I & II
- Teaching and Assessment Language
- Greek
- The Course is Offered to Erasmus Students
- Yes (to Greek speaking students)
Course Content
- Toxicology in everyday practice. Forensic Toxicology. Postmortem Pharmacokinetics, distribution and drug levels.
- Therapeutic Drug Monitoring (TDM). Methods and clinical applications.
- Clinical Studies. Planning, bioethics and interpretation
- Originals or generics?Bio-equivalence and financial resources conservation
- Basic principles in prescribing medications. Common mistakes in prescribing. Over the counter medications. The cooperation between doctor and pharmacist.
- Drug interactions with clinical significance : The Libby Zion case
- Biological compounds. A novel Pharmacology
- The significance of Pharmacovigilance in drug safety. The role of the physician.
Teaching and Learning Methods - Αssessment
Teaching Method
Lectures in the amphitheater
Use of Information and Communication Technologies
Teaching Organization
Activity | Workload per semester |
Lectures | |
Independent study | 46 |
Student Assessment
- Written final exam with multiple choice questions with brief explanation
- Homework
Scope
Learning Outcomes
The main purpose of the course is to introduce the medical student to the correlation among genotype, pharmacological response and toxicity of drugs. Furthermore, the course focuses on the implication of fundamental principles of genetics in the personalization of drug therapy, prevention of toxicity and development of innovative therapeutics.
Briefly the course covers the following topics:
- Phenotype, genotype, haplotype
- Genetic polymorphisms
- Genetic polymorphisms and pharmacological response
- Correlation between genotype and phenotype
- Genome Wide Strategies
- Candidate gene approaches
- SNPs in personalized medicine
- Toxicogenomics
- Contribution of genomics in Forensic Toxicology
General Abilities
- Adaptation to new situations
- Decision making
- Unsupervised work
- Team work
- Work in the inter-scientific environment
- Production of new research ideas
- Promotion of free, constructive and inductive reasoning
Reading Material
Publications in international peer-reviewed Journals