School of Medicine
University of Patras
>University of Patras



Sector: Division of Basic Medical Sciences II

Clinic/Laboratory: Department of Physiology

Knowledge Subject: Physiology - Neurophysiology

Research Area: Neuroscience, Neurophysiology, Synaptic Transmission, Neuronal Networks & Brain Rhythms, Mechanisms of Memory and Learning, Brain Aging.

University of Patras, Department of Medicine, Lab of Physiology, Rion, 26504 Patras. 2nd level, Building of Preclinical Functions.

+30 2610 969117

Summary of Curriculum Vitae

Costas Papatheodoropoulos was born in Aigion, Greece in 1964. He graduated in Biology, University of Patras (1990) and he received a PhD degree in Neuroscience from the same University (1996). He worked as a post-doc fellow at the Unite 109, Centre Paul Broca, INSERM, Paris (1997-1998). He has taught neuropharmacology to undergraduate medicine students at the University of Thessaly, Greece (1999-2002) taking a contractual position. Visiting scientist at UCL, London, 2007. Since 2001 he works at the Medical Department of the University of Patras as lecturer (2001-2006), assistant professor (2006-2012), associate professor (2013-2018) and he is currently professor of physiology-neurophysiology. His research group uses the in vitro rat hippocampal slice preparation and electrophysiological techniques to study synaptic transmission, synaptic plasticity, neuronal excitability and neuronal synchronization. The most important scientific contributions of his research are the revealing of intrinsic neuronal circuitry diversification along the longitudinal axis of the hippocampus and the discovery of an in vitro model of sharp wave-ripples, which is a fundamental physiological rhythm of the hippocampus. The major part of his current work is focused on the functional diversification of the intrinsic-local circuitry along the longitudinal axis of the hippocampus with emphasis given to differences between the dorsal and the ventral hippocampus. He participates to five undergraduate courses of Physiology and Neurophysiology, in the School of Health Sciences, Univ. of Patras, and in five courses in programs of postgraduate studies. Other activities: Reviewer in >23 scientific journals, member of the administrative council of the Hellenic Society for Neuroscience (HSF) 2000-2014.

Undergraduate Courses

Selected Publications

•    Trompoukis G., Rigas R., Leontiadis L.J. & Papatheodoropoulos C. (2020) Ih, GIRK, KCNQ2/3 and KCNQ1/2 Channels Differently Modulate Sharp Wave - Ripples in the Dorsal and Ventral Hippocampus. Molecular and Cellular Neuroscience: 107, 103531

•    Trompoukis G. & Papatheodoropoulos C. (2020) Dorsal-Ventral Differences in Modulation of Synaptic Transmission in the Hippocampus. Frontiers in Synaptic Neuroscience. In Press. doi: 10.3389/fnsyn.2020.00024

•    Koutsoumpa A. & Papatheodoropoulos C. (2019) Short-term dynamics of input and output of CA1 netwrk greatly differ between the dorsal and ventral rat hippocampus. BMC Neurosci 20:35.

•    Kosmidis EK, Contoyiannis YF, Papatheodoropoulos C, Diakonos FK. (2018) Traits of criticality in membrane potential fluctuations of pyramidal neurons in the CA1 region of rat hippocampus. Eur J Neurosci. 48(6):2343–2353.

•    Papaleonidopoulos V, Kouvaros S, Papatheodoropoulos C. (2018) Effects of endogenous and exogenous D1/D5 dopamine receptor activation on LTP in ventral and dorsal CA1 hippocampal synapses. Synapse. Aug; 72(8):e22033.

•    Papaleonidopoulos V, Papatheodoropoulos C. (2018) β-adrenergic receptors reduce the threshold for induction and stabilization of LTP and enhance its magnitude via multiple mechanisms in the ventral but not the dorsal hippocampus. Neurobiol Learn Mem. 151:71-84.

•    Papatheodoropoulos C. (2018) Electrophysiological evidence for long-axis intrinsic diversification of the hippocampus. Frontiers in Bioscience (Landmark), 23: 109-145.

•    Papaleonidopoulos V., Trompoukis G., Koutsoumpa A. & Papatheodoropoulos C. (2017). A Gradient of Frequency-Dependent Synaptic Properties Along the Longitudinal Hippocampal Axis. BMC Neurosci 18:79.

•    Kouvaros S. and Papatheodoropoulos C. (2017) Prominent differences in sharp wave – ripples and complex spike bursts between the dorsal and the ventral rat hippocampus. Neuroscience, 352: 131-143.

•    Kouvaros S. and Papatheodoropoulos C. (2016) Theta burst stimulation-induced LTP: Differences and similarities between the dorsal and ventral CA1 hippocampal synapses. Hippocampus 26(12): 15542-1559.

•    Papatheodoropoulos C. and Kouvaros S. (2016) High-frequency stimulation-induced synaptic potentiation in dorsal and ventral CA1 hippocampal synapses: the involvement of NMDA receptors, mGluR5, and (L-type) voltage-gated calcium channels. Learn. Mem. 23(9):460-4.

•    Kouvaros S. and Papatheodoropoulos C. (2016) Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGluR5, A2A and cannabinoid CB1 receptors. Neuroscience:317, 47-64.

•    Papatheodoropoulos C. (2015) Striking differences in synaptic facilitation along the dorsoventral axis of the hippocampus. Neuroscience 301:454-470.

•    Kouvaros S., Kotzadimitriou D. and Papatheodoropoulos C. (2015) Hippocampal sharp waves and ripples: Effects of aging and modulation by NMDA receptors and L-type Ca2+ channels. Neuroscience. 298: 26-41.

•    Giannopoulos P. & Papatheodoropoulos C. (2013) Effects of μ-opioid receptor modulation on the hippocampal network activity of sharp wave and ripples. Br. J. Pharmacol. 168:1146-1164.

•    Fragkouli A., Papatheodoropoulos C., Georgopoulos S., Stamatakis A., Stylianopoulou F., Tsilibary E.C. and Tzinia A.K. (2012) Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9. J. Neurochem. 121:239-251.

•    Papatheodoropoulos C. and Koniaris E. (2011) α5-GABAA receptors regulate hippocampal sharp wave – ripple activity in vitro. Neuropharmacology 60(4): 662-673.

•    Papatheodoropoulos C. (2010) Patterned activation of hippocampal network (~10 Hz) during in vitro sharp wave-ripples. Neuroscience 168(2): 429-442.

•    Papatheodoropoulos C. (2008) A possible role of ectopic action potentials in the in vitro hippocampal sharp wave-ripple complexes. Neuroscience 157:495-501.

•    Moschovos C., Kostopoulos G. and Papatheodoropoulos C. (2008) Long-term potentiation of high-frequency oscillation and synaptic transmission characterize in vitro NMDA receptor-dependent epileptogenesis in the hippocampus. Neurobiology of Disease 29(2): 368-380.

•    Papatheodoropoulos C., Sotiriou E., Kotzadimitriou D. and Drimala P (2007) At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes. BMC Neuroscience 8, 60.

•    Papatheodoropoulos C. and Kostopoulos G. (2002) Spontaneous GABAA-dependent synchronous periodic activity in adult rat ventral hippocampal slices. Neurosci. Lett. 319(1): 17-20.

•    Louvel J., Papatheodoropoulos C., Siniscalchi A., Kurcewicz I., Pumain R., Devaux B., Turak B., Chodklewicz J.P., Villemeure J.G. and Avoli M. (2001) GABA-mediated synchronization in the human neocortex: elevations in extracellular potassium and presynaptic mechanisms. Neuroscience 105(4): 803-813.

•    Papatheodoropoulos C. and Kostopoulos G. (2000) Decreased ability of rat temporal hippocampal CA1 region to produce long-term potentiation. Neurosci. Lett. 279(3): 177-180.