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GRAFANAKI KATERINA, Special Laboratory Teaching Staff

GRAFANAKI KATERINA

Sector: Division of Internal Medicine ΙΙ

Clinic/Laboratory: Department of Dermatology

Knowledge Subject: Dermatology and Venereology

Research Area: Dermatology and Venereology with specialisation in Dermato-oncology

2610996123 grafanaki@med.upatras.gr

Office hours

Download Curriculum Vitae

Summary of Curriculum Vitae

2024: Training and certification in cryosurgery and management of skin cancers, A. Syngros Hospital, Athens, Greece.

2021-2022: Fulbright Visiting Research Scholar and National Cancer Institute Fellow, NIH-National Cancer Institute (NCI), Center for Cancer Research, Laboratory of Cancer Biology and Genetics, Bethesda, MD, USA

2021: Training in Dermatoscopy and Dermato-oncology, A. Syngros Hospital, Athens, Greece.

2021: Board Certification in Dermatology and Venereology, School of Medicine, University Hospital of Patras.

2018-2021: Resident in Dermatology and Venereology, School of Medicine, University Hospital of Patras.

2016-Today: Faculty staff (E.D.I.P; Special Research and Teaching Personnel) at the Department of Dermatology - Venereology, School of Medicine, University of Patras.

2016: PhD, University of Patras, School of Medicine, Department of Biochemistry.

2010-2012: Residency in Internal Medicine at the Kalavryta General Hospital, Kalavryta, Greece

2009: Medical license (registration number 135191, Medical Board of Patras 5276)

2009: M.D., Medical Degree, School of Medicine, University of Thessaly, Larissa, Greece. (Grade: Very Good)

1998: M.Sc. in Immunology and Allergy, University of Nottingham, School of Medicine, U.K.

Immunity and the Immune system, Research Methods, Library Dissertation, Molecular Allergy, Advanced Immunobiology, Clinical Allergy, Clinical Immunology, Biotechnology, Research Project, and Dissertation.

1997: B.Sc. with Honours in Biomedical Sciences, APU, Cambridge, U.K.

Selected Publications

 

                                                                                                                Dissertations

  1. Functional genomic analysis of the effect of retinoid analogues on human keratinocytes (PhD Thesis 2016, Department of Biochemistry, School of Medicine, University of Patras).
  2. HIV treatment. (April 1997, B. Sc. Thesis)
  3. The effect of female sex hormones on human airway smooth muscle proliferation. (September 1998, Μaster’s Research Dissertation).
  4. Understanding the immunologic basis of the mechanisms involved in transplantation rejection. (December 1998, Master’s Bibliographic Dissertation)

 

In peer-reviewed journals

  1. Papatheodorou L. K., Malizos K. N., Poultisidis L. A., Hantes M. E., Giannouli S., Grafanaki K., Ioannou M. G., Koukoulis G. K., Protopappas V. C., Fotiadis D. I. and Stathopoulos C. (2009) Effect of transosseus application of low-intensity ultrasound at the tendon graft-bone interface healing: Gene expression and histological analysis in rabbits. Ultrasound Med Biol 35: 576-584.
  2. Malizos KN, Papatheodorou LK, Hantes ME, Grafanaki K., Karantanas AH and Stathopoulos C. (2009) Low-intensity ultrasound enhances tendon graft-bone interface healing in anterior cruciate ligament reconstruction. A biochemical and image analysis in human. Osteoarthritis and Cartilage. 17: S250.
  3. Bariamis S. E., Magoulas G. E., Grafanaki K., Pontiki E., Tsegenidis T., Athanassopoulos C. M., Maroulis G., Papaioannou D. and Hadjipavlou-Litina D. (2015) Synthesis and Biological Evaluation of New C-10 Substituted Dithranol Pleiotropic Hybrids. Bioorganic & Medicinal Chemistry, 23: 7251-7263.
  4. Petridis T., Giannakopoulou D., Stamatopoulou V., Grafanaki K., Kostopoulos C. G., Papadaki H.,  Malavaki C.J., Karamanos N. K., Douroumi S., Papachristou D., Magoulas G. E., Papaioannou D. and Drainas D. (2015) Investigation on toxicity and teratogenenicity in rats of a retinoid-polyamine conjugate with potent anti-inflammatory properties. Birth Defects Res B Dev Reprod Toxicol 107:32-44.
  5. Dailiana Z. H., Christou D. C., Grafanaki K., Ioannou M. G., Stathopoulos C., Malizos K. N. and Varitimidis S. (2016) Histological and biochemical evidence related to the collagen quality in torn rotaor cuff tendons. Acta Orthopaedica Belgica 82: 179-188.
  6. Anastasakis D., Skeparnias I., Shaukat N-A., Grafanaki K., Kanellou A., Taraviras S., Papachristou D. J., Papakyriakou A. and Stathopoulos C. (2016) Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development. Nucleic Acids Res 44: 8908-8920.
  7. Skeparnias I., Anastasakis D., Shaukat AN., Grafanaki K. and Stathopoulos C. (2017) Expanding the repertoire of deadenylases. RNA Biology 14:1320-1325.
  8. Grafanaki K. (*), Kontos C., Korfiati A., Shaukat A., Papaioannou D., Scorilas A., Stathopoulos C., and Drainas, D. (2017) The synthetic retinoid-polyamine conjugate RASP induces S/G2 cell cycle arrest and DNA damage response on HaCat cells. Journal of The European Academy of Dermatology and Venereology. 31:53.
  9.  Grafanaki K. (*), Anastasakis D., Kyriakopoulos G., Skeparnias I., Georgiou S. and Stathopoulos C. (2019) Translation regulation in skin cancer from a tRNA point of view. Epigenomics. 11:215-245.
  10. Plachouri K.M., Kyriakou G., Chourdakis V., Georgiou S. and Grafanaki K. (2019) One Stone, Two Birds: Improvement of Early-Onset Vitiligo under Apremilast in a Patient with Plaque Psoriasis. Dermatol Ther. 15: e13064.
  11. Grafanaki K.(*), Vryzaki E., Georgiou S. and Liga M. (2020) Double trouble: influenza and pneumococcal vaccine exacerbation of psoriasis in a new-onset polycythemia vera patient. The Journal of Dermatology 47(7):e263-e264.
  12. Skeparnias I., Αnastasakis D., Grafanaki K., Kyriakopoulos G., Alexopoulos P., Dougenis D., Scorilas A., Kontos C. and Stathopoulos C. (2020) Contribution of miRNAs, tRNAs and tRFs to aberrant signaling and translation deregulation in lung cancer. Cancers 12:3056.
  13. Grafanaki K.(*), Kourakli A, Skeparnias I, Spiliopoulos T, Koumoundourou D, Bravou V, Alexopoulos A, Symeonidis A. and Georgiou S. (2021) Rare lobular capillary hemangioma associated with azacitidine in high-risk myelodysplastic syndrome patient. Dermatol Ther 34:e14884. 
  14. Kyriakopoulos G., Katopodi V., Skeparnias I., Kaliatsi EG., Grafanaki K. and Stathopoulos C. (2021) KRASG12C can either promote or impair cap-dependent translation in two different lung adenocarcinoma cell lines. Int J Mol Sci 22:2222.
  15. Lygeros S., Danielides G., Grafanaki K. and Riga M. (2021) Matrix metalloproteinases and chronic rhinosinusitis with nasal polyposis. Unravelling a puzzle through a systematic review. Rhinology. 2021 Mar 17. doi: 10.4193/Rhin20.578.
  16. Grafanaki K. (*), Kontos C., Anastasakis D., Kyriakopoulos G., Skeparnias I., Korfiati A., Theofilatos K., Mavroudi S., Magoulas G., Papaioannou D., Scorilas A., Stathopoulos C. and Drainas D. (2021) Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes. Pharmacogenomics J. 2021 Jun 18. 1473-1150. doi: 10.1038/s41397-021-00241-9.
  17. Grafanaki K. (*), Georgiou S., and Stratigos AJ. (2021) Solidarity and voluntarism amid the COVID-19 pandemic: skin cancer screening for blood donors. Dermatol Pract Concept. 2021;11(3):e2021080. DOI: https://doi.org/10.5826/dpc.1103a80
  18. Plachouri K.M., Mulita F., Grafanaki K. and Georgiou S. (2021) Remission of genital and generalized extragenital lichen sclerosus et atrophicus under pulse therapy with intravenous steroids. BMJ Case Reports 2021 Apr 30;14(4):e241900.
  19. Lygeros S., Danielides G., Kyriakopoulos G, Grafanaki K., Tsapardoni F., Stathopoulos C., and V. Danielides. (2021) Evaluation of MMP-12 expression in chronic rhinosinusitis with nasal polyposis. Rhinology epub ahead of print doi: 10.4193/Rhin21.320
  20. Lygeros S., Danielidi A., Tzelepi V. and Grafanaki K. (2021) An Unusual Polypoid Septal Mucosal Melanoma: Overview and Diagnostic Pitfalls. Cureus. December 2021. epub ahead of print.
  21. Korfiati A., Grafanaki K. (*), Kyriakopoulos G., Skeparnias I., Georgiou S., Sakellaropoulos G., and Stathopoulos C. (2022) Revisiting miRNA association with melanoma recurrence and metastasis from a machine learning point of view. Int. J. Mol. Sci. 2022, 23(3), 1299; https://doi.org/10.3390/ijms23031299.
  22. Grafanaki K. (*), Lygeros S., Vryzaki E. and Georgiou S. (2022) A rare Vardenafil associated Stevens Johnson Syndrome - toxic epidermal necrolysis. BMJ Case Reports 2022. epub ahead of print. DOI: http://dx.doi.org/10.1136/bcr-2022-249013
  23. Grafanaki K. (*), Lygeros S, Spyridonidis A, Liga M. (2022) Tongue graft-versus-host disease: remission with ruxolitinib. BMJ Case Rep. 2022 May 23;15(5):e247888. doi: 10.1136/bcr-2021-247888. PMID: 35606043.
  24. Grafanaki K (*), Merlino G, Day CP. (2022) Making a mouse out of a molehill: how precision modeling repurposes drugs for congenital giant nevi. Trends Cancer. 2022 Aug;8(8):626-628. doi: 10.1016/j.trecan.2022.06.004. Epub 2022 Jun 17. PMID: 35718707; PMCID: PMC9308749.
  25. Antonatos C, Grafanaki K, Asmenoudi P, Xiropotamos P, Nani P, Georgakilas GK, Georgiou S, Vasilopoulos Y. (2022) Contribution of the Environment, Epigenetic Mechanisms and Non-Coding RNAs in Psoriasis. Biomedicines. 2022 Aug 9;10(8):1934. doi: 10.3390/biomedicines10081934. PMID: 36009480; PMCID: PMC9405550.
  26. Antonatos C, Patsatsi A, Zafiriou E, Stavrou EF, Liaropoulos A, Kyriakoy A, Evangelou E, Digka D, Roussaki-Schulze A, Sotiriadis D, Georgiou S, Grafanaki K, Moschonas NΚ, Vasilopoulos Y. (2023) Protein network and pathway analysis in a pharmacogenetic study of cyclosporine treatment response in Greek patients with psoriasis. Pharmacogenomics J. 2023 Jan;23(1):8-13. doi: 10.1038/s41397-022-00291-7. Epub 2022 Oct 13. PMID: 36229649.
  27. Nani P, Ladopoulou M, Papaioannou EH, Papagianni ED, Antonatos C, Xiropotamos P, Kapsoritakis A, Potamianos PS, Karmiris K, Tzathas C, Patsatsi A, Lazaridou E, Zafiriou E, Roussaki-Schulze A, Georgiou S, Grafanaki K, Georgakilas GK, Vasilopoulos Y. (2023) Pharmacogenetic Analysis of the MIR146A rs2910164 and MIR155 rs767649 Polymorphisms and Response to Anti-TNF Treatment in Patients with Crohn's Disease and Psoriasis. Genes (Basel). 2023 Feb 9;14(2):445. doi: 10.3390/genes14020445. PMID: 36833372; PMCID: PMC9957441.
  28. Grafanaki K (*), Bania A, Kaliatsi EG, Vryzaki E, Vasilopoulos Y, Georgiou S. (2023) The imprint of exposome on the development of atopic dermatitis across the lifespan: A narrative review. J. Clin. Med. 2023, Mar 11;12(6):2180. doi: 10.3390/jcm12062180. PMID: 36983182; PMCID: PMC10054623.
  29. Grafanaki K (*), Antonatos C, Maniatis A, Petropoulou A, Vryzaki E, Vasilopoulos Y, Georgiou S, Gregoriou S. (2023) Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers. J Clin Med. 2023 Jun 12;12(12):4000. doi: 10.3390/jcm12124000. PMID: 37373692; PMCID: PMC10299550.
  30. Grafanaki K (*), Grammatikakis I, Ghosh A, Gopalan V, Olgun G, Liu H, Kyriakopoulos GC, Skeparnias I, Georgiou S, Stathopoulos C, Hannenhalli S, Merlino G, Marie K, Day CP. (2023) Noncoding RNAcircuitry in melanoma onset, plasticity, and therapeutic response. Pharmacol and Therapy. 2023. Aug;248:108466. doi: 10.1016/j.pharmthera.2023.108466. Epub 2023 Jun 8. PMID: 37301330.
  31. Lygeros S, Danielides G, Kyriakopoulos GC, Tsapardoni F, Grafanaki K, Stathopoulos C, Danielides V. (2023) Expression profiles of MMP-9 and EMMPRIN in chronic rhinosinusitis with nasal polyps. Acta Otorhinolaryngol Ital. 2023 Dec;43(6):400-408. doi: 10.14639/0392-100X-N2197. Epub 2023 Jul 28. PMID: 37519135; PMCID: PMC10773546.
  32. Antonatos C, Grafanaki K, Georgiou S, Evangelou E, Vasilopoulos Y. Disentangling the complexity of psoriasis in the post-genome-wide association era. (2023) Genes Immun. 2023 Oct;24(5):236-247. doi: 10.1038/s41435-023-00222-x. Epub 2023 Sep 16. PMID: 37717118.
  33. Makris KC, Langston MA, Islam KT, Holmes P, Chadeau-Hyam M, Smirnov AI, Du X, Thessen AE, Cui Y, Zhang K, Manrai AK, Motsinger-Reif A, Patel CJ; Members of the Exposomics Consortium. (2024) Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs). Exposome. 2024 Jan 17;4(1):osae001. doi: 10.1093/exposome/osae001. PMID: 38344436; PMCID: PMC10857773.
  34. Antonatos C, Pontikas A, Akritidis A, Georgiou S, Stratigos AJ, Kleidona IA, Gregoriou S, Grafanaki K (*), Vasilopoulos Y. Neuroticism and inflammatory skin diseases: a bidirectional Mendelian randomization study. Arch Dermatol Res. 2024 May 24;316(6):213. doi: 10.1007/s00403-024-03017-w. PMID: 38787431.
  35. Robert O Wright, Konstantinos C Makris, Pantelis Natsiavas, Timothy Fennell, Blake R Rushing, Ander Wilson, Members of the Exposomics Consortium. (2024) A long and winding road: culture change on data sharing in exposomics, Exposome, Volume 4, Issue 1, 2024, osae004, https://doi.org/10.1093/exposome/osae004
  36. Grafanaki K. (*), Kourea H., Liga M., Vryzaki E., Georgiou S., Apalla Z. (2024) Dermoscopy and Histology of Primary Cutaneous Aggressive Epidermotropic CD8+ T-Cell Lymphoma. Dermatology Practical & Conceptual. Accepted, In Press.
  37. Z. Apalla, A. Freites-Martinez, K. Grafanaki, A. Ortiz-Bruguez, V. Nikolaou, D. Fattore, P. Sollena, S. Deverapalli, S. Babakoohi, A. Galimont, N. Kluger, M. Beylot-Barry, C. Larocca, C. Iriarte, J. Smith, I. Tattersall, R. Dodiuk-Gad, M. Sauder, C. Carrera, B. Kwong, M. Whitley, N. Leboeuf, P. Romano, M. Starace, V. Mateeva, J. Riganti, J. Hirner, AB. Patel, CM. Reyes-Habito, L. Kraehenbuehl, M. Kheterpal , M. Fida, J. Hassel, M. Lacouture, V. Sibaud. (2024) Management of Human Epidermal Growth Factor Receptor inhibitors-related acneiform rash: A position paper based on the first Europe/USA Delphi consensus process. JEADV In Press.
  38. Grafanaki K (*), Antonatos C, Maniatis A, Vryzaki E, Vasilopoulos Y, Georgiou S, AJ Stratigos, Gregoriou S. (2024) Immunological Advancements in Hand Eczema Treatment: Progress with Small Molecules and Biologics. Current Treatment Options in Allergy. Accepted.

 

(*) denotes corresponding author.

 

In national journals

  1. Apalla Z, Nikolaou V, Grafanaki K. Guidelines & latest developments in the surgical treatment of skin cancer. Acneiform exanthem (papulopastular) in patients with cancer. Special Issue in EDAE News (Journal of the Greek Dermatology and Venereology Society). (2024) EDAE_61.
  2. Apalla Z, Nikolaou V, Grafanaki K. Hairloss in patients with cancer. Special Issue in EDAE News (Journal of the Greek Dermatology and Venereology Society). (2024) EDAE_61.
  3. Apalla Z, Nikolaou V, Grafanaki K. Drug-related oral mucositis in patients with cancer. Special Issue in EDAE News (Journal of the Greek Dermatology and Venereology Society). (2024) EDAE_61.
  4. Apalla Z, Nikolaou V, Grafanaki K. Pruritus in patients with cancer. Special Issue in EDAE News (Journal of the Greek Dermatology and Venereology Society). (2024) EDAE_61.
  5. Apalla Z, Nikolaou V, Grafanaki K. Nail changes due to antineoplastic therapies in patients with cancer. Special Issue in EDAE News (Journal of the Greek Dermatology and Venereology Society). (2024) EDAE_61.
  6. Apalla Z, Nikolaou V, Grafanaki K. Hand – Foot syndrome in patients with cancer. Special Issue in EDAE News (Journal of the Greek Dermatology and Venereology Society). (2024) EDAE_61.

 

 

Book chapters

  1. Toumpeki C., Stamatopoulou V., Bikou M., Grafanaki K., Stathopoulos C. and Drainas D. (2014) Targeting RNase P. In: “Antibiotics: Targets, Mechanisms and Resistance” Eds C. Gualerzi, L. Brandi, A. Fabbreti and C. L. Pon Wiley-VCH Verlag GmbH & Co. (Chapter 14, pp 355-366).

Other Activities

EDITORIAL DUTIES

Reviewer for: Journal of The German Society of Dermatology (JDDG), British Medical Journal-Case Reports, Cancers, Journal of Clinical Medicine, International Journal of Molecular Sciences, Genes, International Journal of Environmental Research and Public Health, Nature Scientific Reports.

 

PARTICIPATION IN RESEARCH GRANTS

  1. GSRT 2003, Greece-France Bilateral R&D collaboration (PLATON-EGIDE)
  2. Hellenic Society of Orthopedics & Trauma 2007 (BIOMED Institute, Larissa)
  3. Hellenic Society of Orthopedics & Trauma 2011
  4. GSRT 2011 «ΑRΙSΤΕΙΑ» (“Excellence”), “Dissecting the involvement and dynamic networks of tRNA expression, signaling and translation in lung cancer”
  5. “Fondation Sante 2016” “Switching from adaptation to regulation: the role of the S. aureus glyS T-box riboswitch
  6. “ELIDEK 2020 Riboregulon” “Riboswitches as modulators of bacterial infections and antibiotic resistance”.
  7. Participation in APOLO: AtoPic dermatitis - a crOss sectionaL study on disease characteristics and impact on patients 2022.
  8. Participation in Janssen’s psoriasis Tremfya clinical trial 2023.
  9. National Eczema Association Catalyst Research Grant 2024 “Decoding the complex architecture of atopic dermatitis in the post-genomic era (ATOMIC).”

 

 

PARTICIPATION IN TRAINING PROGRAMS

  1. 2024: Training and Certification in Cryosurgery and management of skin cancers, A. Syngros hospital, Athens, Greece.
  2. 2021: Training in Dermatoscopy / Dermato-oncology, A. Syngros hospital, Athens, Greece.
  3. 2019: NIH-National Cancer Institute (NCI), Center for Cancer Research, Laboratory of Cancer Biology and Genetics training in melanoma inherent and acquired resistance to targeted and immune-based therapeutics, Bethesda, MD, USA.
  4. 2018: LLP-ERASMUS teaching at the Laboratory of Prof. Hubert D. Becker, University of Strasbourg, France.
  5. 2016: LLP-ERASMUS training visit at the Laboratory of Prof. Hubert D. Becker, University of Strasbourg, France.
  6. 2008: LLP-ERASMUS exchange visit at the Laboratory of Prof. Hubert D. Becker, University of Strasbourg, France.

 

DISTINCTIONS

2023: EDAE Hellenic Society of Dermatology and Venereology Fellowship for Melanoma Research Presentation at EADO 2023

2022: National Cancer Fellowship (NCI) June-August 2022, NIH-National Cancer Institute (NCI), Center for Cancer Research, Laboratory of Cancer Biology and Genetics, Bethesda, MD, USA

2022: EDAE Hellenic Society of Dermatology and Venereology Fellowship for Melanoma Research

2021-2022: Fulbright Visiting Research Scholar, NIH-National Cancer Institute (NCI), Center for Cancer Research, Laboratory of Cancer Biology and Genetics, Bethesda, MD, USA

2018: Distinction Award for humanitarian and voluntary medical services by the Hellenic Red Cross – Samaritans, Rescuers and Lifeguards Sector.

2018: Distinction Award for voluntarism in Bone Marrow Donation and Skin Cancer Prevention Education in Western Greece by the Regional Governor of Western Greece.

 

AWARDS

2021: 30th EADV Virtual Congress 2021, UCB Scholarship.

2021: 47th Panhellenic Medical Conference, 20-22 May 2021, Best Basic Research Presentation Award

2019: 70th Hellenic Society of Biochemistry and Molecular Biology Conference, 1st Prize.

2018: 27th tRNA Conference in Strasbourg, France, Best Poster presentation.

2007: 2nd Conference of the Hellenic Society of Arthroscopy, 1st Prize.

 

MEMBERSHIPS

AACR (American Academy for Cancer Research)

EADV (European Academy of Dermatology and Venereology)

EAACI (European Academy of Allergology and Clinical Immunology)

EEMB (Hellenic Society of Biochemistry and Molecular Biology)

EDAE (Hellenic Society of Dermatology and Venereology)

Member of the Hellenic Melanoma Society

Member of the Hellenic Dermoscopy Society

Member of the Hellenic Medical Association

Member of the Medical Board of Patras

Member of the Exposomics Consortium (NIH/NIEHS)

Member of the EADV Task Force of Supportive Dermato-Oncology.