GEORGAKOPOULOS ANASTASIOS, Special Laboratory Teaching Staff
Sector: Division of Internal Medicine Ι
Clinic/Laboratory: Department of Pathology
Knowledge Subject: Molecular Biology with emphasis on Immunology
Research Area: Chromatin structure, Stochastic gene expression, Coregulation of expression between host and HIV genes
Building of Preclinical facilities of Medical School, 1st Floor K25.01.35
+30 2610-996102 georgako@upatras.gr
Office hours
Monday, Tuesday, Thursday 12.00-1400 p.m.
Summary of Curriculum Vitae
Dr. T. Georgakopoulos holds a degree in Physics from the University of Ioannina (1987) and a doctorate in Molecular Biology from the University of Crete (1996). He has worked as a postdoctoral researcher or collaborating researcher at the Institute of Marine Biology of Crete (IMBBC-HCMR) (1997-1998), at the Institute of Molecular Biology of Crete (IMBB-FORTH) (1998-2000), and since 2000 as a postdoctoral researcher at the Department of Medical Medicine of the University of Patras-Greece. Today he is Senior Scientist as a member of the scientific personnel (EDIP) of the University of Patras in the Department of Medicine (2015-today). He has taught Biology-Molecular/Biochemistry, Molecular-Immunology, Laboratories of Immunology and Scientific Methodology at the Hellenic Open University, in the undergraduate and graduate programs of the Medical School. His research interests focus mainly on the investigation of the transcriptional expression of viruses and of the mechanisms of gene activation or silencing in the immune system, the role of chromatin, interchromosomal interactions, monoallelic gene expression and stochastic events during these molecular processes. The ultimate goal is to correlate these molecular events with the onset of autoimmune diseases and/or pathological conditions of the immune system such as HIV infection
Selected Publications
SELECTED PUBLICATIONS
Georgakopoulos T, Thireos G. Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription. EMBO J. 1992; 11:4145-4152.
Georgakopoulos T, Gounalaki N, Thireos G. Interdependent function of the GCN5 and ADA2 proteins in mediating transcriptional activation by acidic activators. Mol Gen Genet. 1995; 246:723-728.
Argyropoulos C, Nikiforidis GC, Theodoropoulou M, Adamopoulos P, Boubali S, Georgakopoulos T, Paliogiani F, Papavasiliou AG, Mouzaki A. Mining microarray data to identify transcription factors expressed in naïve resting but not activated T lymphocytes. Genes Immun. 2004; 5(1):16-25.
Georgakopoulos T, Panagoulias I, Aggeletopoulou I, Agelopoulos M, Thanos D, Mouzaki A. Transcription factor Ets-2 acts as a preinduction repressor of Interleukin-2 (IL-2) trasncription in naïve T helper lymphocytes J Biol Chem. 2016; 291(52): 26707-26721.
Panagoulias I, Karagiannis F, Aggeletopoulou I, Georgakopoulos T, Argyropoulos C, Akinosoglou K, Gogos C, Skoutelis A, Mouzaki A. Ets-2 Acts as a Transcriptional Repressor of the Human Immunodeficiency Virus Type 1 through Binding to a Repressor-Activator Target Sequence of 5′-LTR. Front Immunol. 2018; 8:1924.
Anastasopoulou S., Georgakopoulos T., Mouzaki A. HIV-1 Transcriptional Activator Tat Inhibits IL2 Expression by Preventing the Presence of Pol II on the IL2 Promoter Biomolecules 2023, 13(6), 881