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CHRYSIS DIONISIOS, Professor

CHRYSIS DIONISIOS

Sector: Division of Paediatrics & Obstetrics – Gynaecology

Clinic/Laboratory: Department of Paediatrics

Knowledge Subject: Pediatrics - Endocrinology

Research Area: 1. Study of the mechanisms of longitudinal growth in growth plate cartilage during normal and abnormal development with emphasis on apoptosis.2. The role of FGF23 and klotho in phosphate homeostasis in normal children and in situations affecting phosphate homeostasis3. Possible role of the OPG/RANKL system as a cardiovascular risk factor and regulator of bone metabolism in children with subclinical hypothyroidism, obesity, diabetes mellitus type I, and IUGR.4. Investigation and further description of rare disorders in Pediatric Endocrinology (mutations in thyroid hormone receptor α, hypoaldosteronism, pseudohypoaldosteronism, Growth hormone Insensitivity.

Department of Pediatrics 1st fl

2610999546 2610994711 dchrysis@upatras.gr dchrysis@med.upatras.gr

Summary of Curriculum Vitae

UNIVERSITY DEGREE: 1985 M.D. from the Medical School, University of Patras, Greece. DOCTORAL DEGREE: 1) 1997 Thesis in Pediatrics, Pediatric Endocrinology from the Department of Pediatrics, Medical School, University of Patras, Greece. 2) 2004 PhD at Pediatric Sciences, from the Pediatric Endocrinology laboratory, Karolinska Institutet, Stockholm, Sweden. Supervisor Prof Lars Savendahl POSTDOCTORAL TRAINING: 1989-1993 Resident in Pediatrics, Department of Pediatrics, Medical School, University of Patras, Greece. 1993-1995 Fellow in Pediatric Endocrinology, Department of Pediatrics, Medical School, University of Patras, Greece 1995-1998 Clinical Fellow in Pediatric Endocrinology, Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, Medical School, Chapel Hill, N.C., USA. 2001-2004 PhD training program in Pediatric Sciences, Karolinska Institutet, Stockholm, Sweden. QUALIFICATION AS AN ASSOCIATE PROFESSOR: 2008 MEMBERSHIP OF PROFESSIONAL SOCIETIES: 1) Hellenic Endocrine Society 2) Hellenic Society for Pediatric and Adolescent Endocrinology 3) European Society for Pediatric Endocrinology 4) Swedish Medical Society 5) Swedish Society for Pediatric Endocrinology CURRENT POSITION: Associate Professor of Pediatric Endocrinology, Department of Pediatrics, Medical School, University of Patras. Greece since 2008. PREVIOUS POSITIONS: 1985-1987 Doctor in the Greek army 1987-1989 Doctor in the Health Center of Amfilochia as part of the obligatory rural service 1989-1993 Resident in Pediatrics, Department of Pediatrics, Medical School, University of Patras, Greece 1993-1995 Fellow in Pediatric Endocrinology, Department of Pediatrics, Medical School, University of Patras, Greece 1995-1998 Fellow in Pediatric Endocrinology, Division of Endocrinology, Department of Pediatrics, Medical School, UNC at Chapel Hill, NC, USA 1998-1999 Clinical and Research associate, Division of Pediatric Endocrinology, Department of Pediatrics, Medical School, UNC at Chapel Hill, NC, USA. 1999-2001 Guest Researcher, Department of Pediatrics, Division of Endocrinology, Astrid Lindgren Children´s Hospital, Karolinska Institutet, Stockholm, Sweden. 2001-2003 Consultant in Pediatric Endocrinology, Department of Pediatrics, Division of Endocrinology, Astrid Lindgren Children´s Hospital, Karolinska Institutet, Stockholm, Sweden. 2002-2003 Consultant Endocrinologist for the CATCH-22 (22-microdeletion syndrome) team, Karolinska Insitutet, Stockholm, Sweden. Τhe team includes Neurologist, Geneticist, Phycologist, Psyciatrist, Dentist, Craniofacial Surgeon, ENT surgeon, Cardiologist, Immunologist, Speech Pathologist, and Endocrinologist. It is Reference Center for Sweeden. 2003- 2008 Assistant Professor of Pediatric Endocrinology, Medical School, University of Patras, Greece. 2008- παρόν Associate Professor of Pediatric Endocrinology, Medical School, University of Patras, Greece. GRANTS 1. 1998-1999 Lawson Wilkins Pediatric Endocrine Society: Research Fellowship. 2. 1998-1999 Research grant supported by Eli Lilly, Indianapolis, IN, USA. 3. 1998-1999 Research grant supported by Serono, USA. 4. 1999-2001 Research grant from Wenner-Gren Foundation, Stockholm, Sweden. 5. 1999-2000 Wera Ekström´s Research Grant for Pediatric Research, Stockholm, Sweden. 6. 1999-2000 Swedish Research Medical Council Grant, Stockholm, Sweden 7. 1999-2001 Erik Ronnbergs Research Award and Grant, Stockholm, Sweden. 8. 1999-2003 Sven Jerring´s Foundation grant, Stockholm, Sweden. 9. 2000-2003 Swedish Medical Society grant, Stockholm, Sweden. 10. 2000-2004 Sällskapet Barnvård´s grant, Stockholm, Sweden. 11. 2000-2003 Stiftelsen Frimurare Barnhuset grant, Stockholm, Sweden. 12. 2000-2003 Kronprinsessans Lovisa grant, Stockholm, Sweden. 13. 2001-2003 Stiftelsen Samariten grant, Stockholm, Sweden. 14. 2001-2003 Stiftelsen Thuringe, Stockholm, Sweden. 15. 2002-2003 Mary Bevés Foundation grant, Stockholm, Sweden. 16. 2006-2008 Child and Health grant by Procter and Gamble 2006 17. 2009-2013 KIGS (International collaborative study) 18. 2009-2013 GENESIS (International collaborative study) 19. 2013 EASYPOD (International collaborative study) AWARDS 1. The Research Merit Award. Thomas F. Boat Evening of Scholarship. University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA. 2. Hellenic Endocrine Society Pitoulis award of 2008 for the best basic research study.

Undergraduate Courses

Postgraduate Courses

1. Lectures for the postgraduate program (residency program) for the Department of Pediatrics, Medical School, University of Patras. 2. Lectures as invited speaker for the postgraduated programs for residences from other departments of the University of Patras, and Department of Pediatrics of Greek Universities 3. Lectures as invited speaker in international seminars

Selected Publications

1. Chrysis D, Calikogu AS, Ying P, D’Ercole AJ 2001 Insulin-like Growth Factor-I (IGF-I) overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally-specific manner. J. Neurosci. 21: 1481-1489. 2. Chrysis D, Nilsson O, Ritzen M, Savendahl L 2002 Apoptosis is developmentally regulated in rat growth plate. Endocrine; 18:271-8. 3. Chrysis D, Ritzen M, Savendahl L 2003 Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes. J of Endocrinol ; 176:331-337. 4. Mårtensson K, Chrysis D, Sävendahl L. 2004 Interleukin-1 and TNF- act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones. J Bone Miner Res 19:1805-1812. 5. Chrysis D, Zaman F, Chagin A, Takigawa M, Savendahl L 2005 Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-(PI3K) signaling pathway.Endocrinology 146:1391-1397. 6. Chrysis D, Spiliotis BE, Stene M, Cacciari E, Davenport ML. 2006 Gonadotropin secretion in girls with turner syndrome measured by an ultrasensitive immunochemiluminometric assay. Horm Res. 65:261-266. 7. Chagin A, Karimian E, Zaman F, Chrysis D, Savendahl L 2007 Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones. Bone 40:1415-1424. 8. Zaman F, Menendez-Benito V, Eriksson E, Chagin AS, Takigawa M, Fadeel B, Dantuma NP, Chrysis D, Sävendahl L. Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice. Cancer Res. 2007 67:10078-86. 9. Georgopoulos NA, Koika V, Varnavas P, Efthymiadou A, Marioli DJ, Mantagos S, Chrysis D. Can Kallmann syndrome be occasionally diagnosed during childhood? Genetic diagnosis in a child with associated renal agenesis and mirror movements. Asian J Androl. 2009 11:521-3. 10. Chrysis D, Chagin A, Sävendahl L. Insulin-like growth factor-1 restores dexamethasone-induced heart growth arrest in rats: the role of the ubiquitin pathway. Hormones. 2011 10:46-56. 11. Zaman F, Chrysis D, Huntjens K, Fadeel B, Sävendahl L. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PLoS One. 2012;7:e33168. 12. van Mullem A, van Heerebeek R, Chrysis D, Visser E, Medici M, Andrikoula M, Tsatsoulis A, Peeters R, Visser TJ. Clinical phenotype and mutant TRα1. N Engl J Med. 2012 366:1451-3. 13. Eriksson E, Zaman F, Chrysis D, Wehtje H, Heino TJ, Sävendahl L. Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice. PLoS One. 2012;7:e50523. 14. Efthymiadou A, Stefanou EG, Chrysis D. 45,X/46,XY mosaicism: a cause of short stature in males. Hormones. 2012 ;11:501-4. 15. van Mullem AA, Chrysis D, Eythimiadou A, Chroni E, Tsatsoulis A, de Rijke YB, Visser WE, Visser TJ, Peeters RP. Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor; consequences of LT4 treatment. J Clin Endocrinol Metab. 2013;98:3029-38.

Selected Presentations

  • 1999 The annual meeting of the Lawson Wilkins Pediatric Endocrine Society, San Fransisco, CA, USA.
  • 2001 Biomedicine School, Karolinska Institutet, Stockholm, Sweden.
  • 2002 Course for the Biology of the growth plate, Karolinska Institutet, Stockholm, Sweden.
  • 2003 International Advanced Postgraduate course in Growth Karolinska Institutet, Stockholm, Sweden.
  • 2003 EUROGROP. Working group of ESPE for the study of bone and cartilage.
  • 2004 Course for the Biology of the growth plate, Karolinska Institutet, Stockholm, Sweden.
  • 2005 The annual seminar of the Pediatric Department, Medical School, University of Patras, Greece.
  • 2005 International Advanced Postgraduate course in Growth Karolinska Institute, Stockholm, Sweden.
  • 2005 Educational program of the Department of Pediatrics, Medical School, University of Ioannina, Ioannina, Greece.
  • 2006 The annual seminar of the Pediatric Department, Medical School, University of Creta, Herakleion, Greece.
  • 2006 International Seminar for bone age assessment, Pediatric Endocrine Unit, Karolinska Institutet, Stockholm, Sweden.
  • 2006 Calcium metabolism and related disorders: Seminar for the residency training program of Sweden, organized by the Pediatric Endocrine Unit, Karolinska Institute, Stockholm, Sweden.
  • 2006 Annual seminar of the Pediatric Department, Medical School, University of Ioannina, Ioannina, Greece.
  • 2006 International Advanced Postgraduate course in Growth Research, Karolinska Institute, Stockholm, Sweden.
  • 2006 20th Postgraduate meeting of the Hellenic Endocrine Society, Portaria, Pelion.
  • 2006 Annual meeting the Hellenic Society for child and adolescent Endocrinology.
  • 2006 Annual meeting of the Hellenic Pediatric Society. Aldemar, Skafidia.
  • 2007 34th Annual meeting of the Hellenic Endocrine Society.
  • 2007 Annual meeting of Hellenic Society for child and adolescent Endocrinology.
  • 2008 Annual Intensive courses of the Hellenic Endocrine Society, Athens.
  • 2009 Annual meeting of the Hellenic Society for child and adolescent Endocrinology.
  • 2010 4th Advanced Seminar organized by the European Society for Pediatric Endocrinology (ESPE), Stockholm, Sweden.
  • 2011 38th meeting of the Hellenic Endocrine Society, Thessaloniki
  • 2011 Postgraduate courses of the Department of Psychiatry, Medical School, Univesity of Patras, Patra..
  • 2011 Postgraduate courses of the Division of Endocrinology, Internal Medicine, Medical Scool, University of Patras, Greece.
  • 2011 7th meeting of Diabetes, Center for Diabetes, Medical School, Univesity of Patras, Greece.
  • 2012 39th Annual meeting of the Hellenic Endocrine Society, Athens.
  • 2012 Postgraduate courses of the Division of Endocrinology, Internal Medicine, Medical Scool, University of Patras, Greece.
  • 2012 Endorama, Organized by the Hellenic Endocrine Society, Patra
  • 2012 Postgraduate course of the Department of Pediatrics, Medical School, Aristoteleion University, Thessaloniki
  • 2013 Annual meeting of the Hellenic Society for child and adolescent Endocrinology.
  • 2013 Postgraduate courses of the Department of Pediatrics, Medical Scool, Univesity of Ioannina, Ioannina.

PhD Theses Advisor

  • 1) Mermigka Alexandra: Cardiovascular risk factor in children with T1DM
  • 2) Vasilakis Ioannis: The metabolic role of myostatin in children with T1DM
  • 3) Katsantoni Eleni: Study of the OPG/RANKL system in children with subclinical hypothyroidism.
  • 4) Malic Nina: The role of OPG and RANKL in children with urinary track infections.
  • 5) Mpogiatzidou Maria: The levels of AMH in girls with premature adrenarche.
  • 6) Gkentzi Despoina: The role of FGF23 in phosphate homeostasis in normal children.
  • Co-mentor (25%) for the PhD students Farasat Zaman (Effects of chemotherapy on on bone growth and chondrocyte cell death signaling, 2010) and Emma Eriksson (Proteasome Inhibitors, new-promising anticancer drugs. Studies of their effect on longitudinal bone growth, 2013) from the laboratory of Pediatric Endocrinology, Karolinska Institutet, Stockholm, Sweden. http://publications.ki.se/xmlui/bitstream/handle/10616/40260/Farasat-thesis-2010.pdf?sequence=1 http://publications.ki.se/xmlui/bitstream/handle/10616/41493/Thesis.pdf?sequence=4

Other Activities

Scientifically responsible for the laboratory of metabolic disorders, Department of Pediatrics, Medical School, University of Patras. http://www.pgnp.gr/?section=2252&language=el_GR