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Athanasiadou Aglaia, Emeritus Professor

Athanasiadou Aglaia

Period: 1978-2010

Knowledge Subject: Biology -Molecular Genetics

Research Area: Gene therapy- Development of Episomal Vectors for gene thεrapy

Dept of General Biology Medical Faculty

00302610 997689 athanass@med.upatras.gr

Download Curriculum Vitae

Summary of Curriculum Vitae

 

 

Aglaia Athanassiadou Summary of CV

 

Studies: BSc, School of Natural Sciences, University of Athens 

MSc, Genetics, Weizmann Institute of Science and Tel Aviv University, Israel,1973,

PhD, Genetics, Imperial College of Science, London, UK,1978.

Academic Career, Dept of General Biology, Elected Lecturer 1978, became Professor in Molecular Genetics, 2003, Retired 2010, Professor Emeritus 2011.

Post doctoral and sabbatical positions under long term fellowships in (1) NIMR, Lab.of Gene structure and expression, Dr F.Grosveld, Mill Hill, London, UK(1981). (2) Baylor College of Medicine, Mutation detection, Dr  R.Gibbs and Prof. T. Caskey, Houston, USA(1991). (3) Guy's Hospital, GKT School of Medicine, Dr M Antoniou, Division of Medical and Molecular Genetics, London, UK (2000).

Teaching: Undergraduate level, Biology, Genetics, Medical Genetics; Postgraduate level:

Advance topics in Biology, Compartmentalization of the cell and material transfer, Documentation of gene Expression

Research grants: 12 grants as PI, 4 national and 8 EU funded.

Grant  Evaluator The 7th Framework Programme for Research - European Comission              (FP7  EU  Programme); Promotion Foundation of Cyprus; etc.

Reviewer of research publications  For: Molecular Therapy, Human Mutation, Journal of Molecular Biology, Gene Therapy,  Scientific Reports, and Journal of Biotechnology.

Research. (a)Studies on beta-Thalassaemia by Mutation detection, haplotyping and functional analysis of beta-globin gene mutations, in patients treated at the University Hospital; (b)Identification of the first mutation in Familiar Parkinson Disease, in the alpha-synuclein gene and studies of its expression; (c) Development of non-viral, Episomal vectors for gene therapy.

Publications in peer reviewed journals: 63; Presentations in Symposia : 76; Invitation for Presenations:41.

 

 

 

Selected Publications

 

Selected Publications on the development of Episomal Vectors for Gene Therapy

 

  •  Grace Elizabeth Mulia,Virginia Picanço-Castro, Eleana F.Stavrou, Aglaia Athanassiadou , Marxa Leão Figueiredo . Advances in the Development and the Applications of Nonviral, Episomal Vectors for Gene Therapy.Hum Gene Ther. 2021 Oct;32(19-20):1076-1095. doi: 10.1089/hum.2020.310.
  • Virginia Picanço-Castro, Cristiano Gonçalves Pereira, Dimas Tadeu Covas, Geciane Silveira Porto , Aglaia Athanassiadou   and Marxa Leão Figueiredo. Emerging patent landscape for non-viral vectors used for gene therapy. Nature Biotechnology | VOL 38 | February 2020 | 151–158 |
  • Eleana F. Stavrou, Emannuel Simantirakis, Meletios Verras, Carlos Barbas III, George Vassilopoulos, Kenneth R. Peterson, and Aglaia Athanassiadou. Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells. Sci Rep 9, 19765 (2019). https://doi.org/10.1038/s41598-019-56056-z
  • Stavrou E.F., V.M. Lazaris, A. Giannakopoulos, E.Papapetrou, A. Spyridonidis, A. Skountis, N. C. Zoumbos, A. Athanassiadou: The beta-globin Replicator greatly enhances the potential of S/MAR based episomal vectors for gene transfer into human hematopoietic progenitor cells. Scientific Reports | Jan 2017/ 7:40673 | DOI: 10.1038/srep40673.2017
  • Aristeidis Giannakopoulos, Michael Quiviger, Eleana Stavrou, Meletios Verras, Corinne Marie, Daniel Scherman, Aglaia Athanassiadou Efficient episomal gene transfer to human hepatic cells using the pFAR4–S/MAR vector . Mol Biol Rep. 2019 Jun;46(3):3203-3211.https://doi.org/10.1007/s11033-019-04777-9
  • Mickael Quiviger, Aristeidis Giannakopoulos, Sebastien Verhenne, Corinne Marie, Eleana F. Stavrou, Karen Vanhoorelbeke, Zsuzsanna Izsvák, Simon F. De Meyer,  Aglaia Athanasiadou, Daniel Scherman. Improved molecular platform for the gene therapy of rare diseases by liver protein secretion. European Journal of Medical Genetics. Eur J Med Genet. 2018 Apr 26. pii: S1769-7212(17)30610-9. doi:10.1016/j.ejmg.2018.04.010
  • Argyro Sgourou Samantha Routledge, Aglaia Athanassiadou Dionysios  Spathas and Michael . Physiological Levels of HBB Transgene Expression from Replicating Episomal vectors based on the chromosomal element S/MAR. J.of Biotechnology, 143  85–94, 2009
  • Giannakopoulos A1, Stavrou E.F1, Zarkadis I1, Zoumbos N2, Thrasher AJ3,    Athanassiadou A1. The functional role of S/MARs in EBV-based episomal vectors as defined by the stress-induced destabilization profile of the vector backbone sequences  J. Mol. Biol. 387, 1239–1249, 2009
  • Eirini P Papapetrou, Panos G Ziros, Ilina D Micheva, Nicholas CZoumbos,   Aglaia Athanassiadou. Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying a S/MAR elemen. Gene Therapy;13(1):40-51. 2006
  • Eirini P. Papapetrou, Nicholas C. Zoumbos, Aglaia Athanassiadou.. Genetic

      modification of hematopoietic stem cells with non-viral systems: past  progress  

      and future prospects Gene Therapy  Oct;12 Suppl 1:S118-30 2005.         

  • Chow C.M., A. Athanassiadou, S. Raguz, L. Psiouri, L. Harland, M. Malik, M.A.

Aitken, F. Grosveld and  M. Antoniou. LCR-mediated, long-term tissue specific gene expression within replicating episomal plasmid vectors, Gene  Therapy 5 :327-36,  2002

 

 

PhD Theses Advisor

Advisor for the PhD theses of the students:

Orphanos Vasileios, Zarkadis Ioannis, Vezyri Elena, Papachatzopoulou Adamantia, Psiouri Labrini, Sgourou Argyro, Giannakopoulos Aristeidis, Papapetrou Eirini, Polyviou Stavros, Stavrou Eleana, Lazaris Vasileios