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Teaching Staff

expand  Rank : Professor
ALEXANDRIDES THEODORE
ANASTASSIOU EVANGELOS
ANTHRAKOPOULOS MICHAEL
APOSTOLOPOULOS DIMITRIOS
ATHANASOPOULOS ANASTASIOS
BEZERIANOS ANASTASIOS
CHRISTOFIDOU MYRTO
CHRONI ELISABETH
CHRYSIS DIONISIOS
COSTARIDOU LENA
DANIILIDIS VASSILIOS
DECAVALAS GEORGE
DIMITRIOU GABRIEL
DRAINAS DENIS
GEORGIOU SOPHIA
GOGOS CHARALAMPOS
GOUMENOS DIMITRIS
GOURZIS PHILIPPOS
GREKA-SPILIOTI VASILIKI (SPILIOTIS BESSIE E.)
HAHALIS GEORGE
JELASTOPULU ELENI
KALOFONOS CHARALAMPOS
KALPAXIS DIMITRIOS
KARDAMAKIS DIMITRIOS
KONSTANTINOY DIMITRIOS
KYPREOS KYRIAKOS
KYRIAZOPOULOU VENETSANA
LEOTSINIDIS MICHAEL
LIOSSIS STAMATIS-NICK
LYGEROU ZOI
MARANGOS MARKOS
MARKOU KOSTAS
MEGAS PANAGIOTIS
MELACHRINOU MARIA
MITSACOU ADAMANTIA
MOSCHONAS NIKOLAOS
MOUZAKI ATHANASIA
NIKOLOPOULOU VASILIKI
PALIOGIANNI FOTINI
PANAGIOTOPOULOS ILIAS
PANAYIOTAKIS GEORGE
PERIMENIS PETROS
PETROU-PAPADAKI HELEN
PETSAS THEODOROS
PHARMAKAKIS NIKOLAOS
SIMEONIDIS ANARGIROS
SPILIOPOULOU-SDOUGKOU IRIS
SPIRIDONIDIS ALEXANDROS
SPIROPOULOS KONSTANTINOS
STATHOPOULOS CONSTANTINOS
TARAVIRAS STAVROS
TSOLAKIS IOANNIS
TYLLIANAKIS MINOS
VARVARIGOU ANASTASIA
ZARKADIS IOANNIS
ZOLOTA VASSILIKI
expand  Rank : Associate Professor
ASSIMAKOPOULOS KONSTANTINOS
CHEILADAKIS JOHN
DAVLOUROS PERIKLIS
ELLOUL JOHN
GEORGAKOPOULOS CONSTANTINOS
GYFTOPOULOS KONSTANTINOS
KAGADIS GEORGE C.
KALOGEROPOULOU CHRISTINA
KATRIVANOU AGGELIKI
KOUREA ELENI (HELEN)
MAROULIS IOANNIS
NAKSAKIS STEFANOS
PANOS GEORGE
PAPACHRISTOU DIONYSIOS
PAPADOPOULOS VASILEIOS
PASMATZI EFSTATHIA
SAKELLAROPOULOS GEORGE
SOLOMOU AIKATERINI
STATHOPOULOS GEORGIOS
TSOPANOGLOU NIKOS
expand  Rank : Assistant Professor
ALEXOPOULOS PANAGIOTIS
BRAVOU VASSILIKI
FLIGKOU FOTEINI
GLIATIS IOANNIS
KARATZA AGGELIKI
KATSANOS KONSTANTINOS
KOLETSIS EFSTRATIOS NIKOLAOS
KOUTRAS AGGELOS
PANAGIOTAKOPOULOS GEORGE
PAPACHRISTOU EVAGGELOS
SOLOMOU-LIOSI ELENA
TSAMANDAS ATHANASSIOS C.
VELISSARIS DIMITRIOS
ZAMPAKIS PETER
expand  Rank : Lecturer
NIKA KONSTANTINA
SYGGELOS SPYROS
KALPAXIS DIMITRIOS
Rank:Professor
Sector:Division of Basic Medical Sciences I
Clinic/Laboratory:
Department of Biochemistry
Knowledge Subject:Biochemistry
Research Area:Structure and function of the protein-synthesizing machine-mechanism of action of antibiotics
Address:Department of Biochemistry, School of Medicine, University of Patras, 26504-Patras, Greece
Office:Building for Preclinical Activities, 3rd Floor
Phone:2610-996124
Fax:2610-969167
E-mail:
dimkal@med.upatras.gr
Personal Website:
http://biochemistry.med.upatras.gr/lang_en/humanResources/viewCV/5
Download Short CV
 

Summary of Curriculum Vitae

Dimitrios Kalpaxis was born in Moulki of Corinth in 1951. He studied Biology (1970-1974) and Chemistry (1975-1979) in University of Patras. He was a post-graduate student in the School of Sciences of University of Patras and received his PhD in 1981. He worked as a Research Fellow (1980-1982), Lecturer (1982-1986), Assistant Professor (1986-1996), Associate Professor (1996-2003) and Professor (2003-today) at the School of Medicine of University of Patras. He has been a Visiting Scholar at the School of Medicine of Nurnberg University (1988, 1989) and Visiting Research Fellow at the Max-Plank Institute of Berlin (2000). He has given a series of lectures and seminars in Academic and Research Centers of Europe.
 
His research interests are focused on the Biochemistry field, in particular on the structure and function of the protein-synthesizing machine and the mechanism of action of antibiotics. He has published extensively in international journals and books, and has presented his research in various international conferences. He is a member of the editorial board of the Open Enzyme Inhibition Journal and the Community Medicine & Health Education, reviewer in 18 international journals, reviewer of research proposals submitted in national and international financial fora, and member of 6 scientific societies.
 
He has been director of the post-graduate Programme in Basic Medicinal Sciences of University of Patras (2006-2010), member of the Committee for Post-Graduate Studies (2006-2008), and member of the Research Committee (2007-2010) of University of Patras. Currently, he was elected to be the Vice Rector for Strategic Research Planning and Development in the University of Patras (2010-2014).

Undergraduate Courses

Postgraduate Courses

  • PΑ4. Introduction in Biochemistry (Post-Graduate Programme in Informatics for Life Sciences)
  • Methodology for Research in Basic Medicinal Sciences-Part I (Post-Graduate Programme in Basic Medicinal Sciences)
  • Reasearch Topics (Post-Graduate Programme in Basic Medicinal Sciences)
  • Introduction in Molecular and Cellular Biology (Post-Graduate Programme in Basic Medicinal Sciences)
  • Laboratory Training I (Post-Graduate Programme in Basic Medicinal Sciences)
  • Methodology for Research in Basic Medicinal Sciences-Part II (Post-Graduate Programme in Basic Medicinal Sciences)
  • Laboratory Training II (Post-Graduate Programme in Basic Medicinal Sciences)
  • Molecular Basis of Transcription and Translation(Post-Graduate Programme in Basic Medicinal Sciences)
  • Clinical Biochemistry (Post-Graduate Programme in Basic Medicinal Sciences)
  • Presentation and Discussion of experimental Results (Post-Graduate Programme in Basic Medicinal Sciences)

Selected Publications

Read all the publications
  1. O. N. Kostopoulou, A. D. Petropoulos, G. P. Dinos, T. Choli-Papadopoulou, D. L. Kalpaxis*, Investigating the entire course of telithromycin binding to Escherichia coli ribosomes, Nucleic Acids Res., 2012, 40: 5078-5087.
  2. E. C. Kouvela, D.L. Kalpaxis, D.N. Wilson and G.P. Dinos*, A distinct mode of interaction of a novel ketolide antibiotic that displays enhaced antimicrobial activity. Antimicrob. Agents Chemother., 2009, 53: 1411-1419.
  3. A. D. Petropoulos, E. C. Kouvela, A. L. Starosta, D. N. Wilson, G. P. Dinos and D. L. Kalpaxis*, Time-resolved binding of azithromycin to Escherichia coli ribosomes. J. Mol. Biol., 2009, 385: 1179-1192.
  4. S. Pytharopoulou, E. Sazakli, K. Grintzalis, C. D. Georgiou, M. Leotsinidis, D. L. Kalpaxis*, Translational responses of Mytilus galloprovincialis to environmental pollution: integrating the responses of oxidative stress and other biomarkers into a general stress index. Aquat. Toxicol., 2008, 89: 18-27.
  5. A. D. Petropoulos, E. C. Kouvela, G. P. Dinos and D. L. Kalpaxis*, Step-wise binding of tylosin and erythromycin to Escherichia coli ribosomes, characterized by kinetic and footprinting analysis. J. Biol. Chem., 2008, 283: 4756-4765.
  6. E. C. Kouvela, G. V. Gerbanas, M. A. Xaplanteri, A. D. Petropoulos, G. P. Dinos and D. L. Kalpaxis*, Changes in the conformation of 5S rRNA cause alterations in principal functions of the ribosomal nanomachine. Nucleic Acids Res., 2007, 35: 5108-5119.
  7. Ε. Κouvela, A. D. Petropoulos and D. L. Kalpaxis*, Unravelling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. J. Biol. Chem., 2006, 281: 23103-23110.
  8. A. Tsagkalia, F. Leontiadou, M. A. Xaplanteri, G. Papadopoulos, D. L. Kalpaxis*, T. Choli-Papadopoulou*, Ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus display multiple defects in ribosomal functions and sensitivity against erythromycin. RNA, 2005, 11: 1633-1639.
  9. Μ. A. Xaplanteri, A. D. Petropoulos, G. P. Dinos and D. L. Kalpaxis*, Localization of spermine binding sites in 23S rRNA by photoaffinity labeling: parsing the spermine contribution to ribosomal 50S subunit functions. Nucleic Acids Res., 2005, 33: 2792-2805.
  10. A. Petropoulos, M. A. Xaplanteri, G. P. Dinos, D. N. Wilson and D. L. Kalpaxis*, Polyamines affect diversely the antibiotic potency: insight gained from kinetic studies of the blasticidin S and spiramycin with functional ribosomes. J. Biol. Chem., 2004, 279: 26518-26525.
  11. G. Dinos, D. Wilson, Y. Teraoka, W. Szaflarski, P. Fucini, D. L. Kalpaxis and K. H. Nierhaus*, Dissecting the inhibition mechanisms of edeine and pactamycin: Antagonistic interplay on the ribosome between these translational inhibitors. Mol. Cell, 2004, 13: 113-124.
  12. M. A. Xaplanteri, A. Andreou, G. P. Dinos and D. L. Kalpaxis*, Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: Revisiting the mechanism of chloramphenicol action. Nucleic Acids Res., 2003, 31: 5074-5083.
  13. I. Amarantos, I. K. Zarkadis and D. L. Kalpaxis*, The identification of spermine binding sites in 16S rRNA allows interpratation of the spermine effect on ribosomal 30S subunit functions. Nucleic Acids Res., 2002, 30: 2832-2843.
  14. I. Amarantos, and D. L. Kalpaxis*, Photoaffinity polyamines: interactions with AcPhe-tRNA free in solution or bound at the P-site of Escherichia coli ribosomes. Nucleic Acids Res., 2000, 28: 3733-3742.
  15. R. Marschalek, D. L. Kalpaxis, T. Dingermann*, Temperature sensitive synthesis of transfer RNAs in vivo in Saccharomyces cerevisiae. EMBO J., 1990, 9: 1253-1258.

Selected Presentation

D. L. Kalpaxis, Binding of antibiotics to the ribosome revisited: Kinetics, time-resolved footprinting and NMR analysis reveal a time-dependent mechanism of the ribosome-ligand interaction, 3rd SEE-DRUG Workshop on Emerging analytical techniques in Protein Characterization, Patras, Greece, September 19-20, 2013.
D. L. Kalpaxis, Rules in ribosome accessibility: Most of antibiotics act as slow binding inhibitors, 10th Workshop on Experimental Strategies for Ribosomal Research, Schloss Ringberg, Germany, April 19-22, 2009.
D. L. Kalpaxis, Biomonitoring the Gulf of Patras (Greece) using caged mussels, Workshop on the MED POL Biological Effects: Achievements and Future Orientation, Alessandria, Italy, December 20-21, 2006.
D. L. Kalpaxis, Insights into the mechanism of polyamine action on the function of the large ribosomal subunit using photoaffinity labeling techniques, Max-Planck Institut fur Molekulare Genetik, Berlin, Germany, September 24, 2002

PhD Theses Advisor

  1. Michelinaki, Μ. (1997) “Mechanisms of inhibition and activation of ribosomal peptidyl transferase in Escherichia coli from derivatives of chloramphenicol and monovalent ions”, School of Medicine, University of Patras.
  2. Karahalios, P. (1999) “Effect of polyamines and polyamine derivatives on protein synthesis, polyamine uptake, and growth of Escherichia coli”, Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  3. Amarantos, I. (2001) “Effect of polyamines on the ribosomal structure and function”, Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  4. Xaplanteri, M. (2004) “Structural and functional studies on the effect of spermine on the 50S ribosomal subunit of Escherichia coli”, Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  5. Petropoulos, A. (2007) «Effect of ionic environment on the structure and function of antibiotics which inhibit protein synthesis», Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  6. Kouvela, Α. (2008) «Investigation of the mechanism of action of antibiotics-inhibitors of protein synthesis in Escherichia coli » Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  7. Pytharopoulou S. (2012) «Perturbations in the cellular protein synthesis as a biomarker of environmental stress», Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  8. Kostopoulou, Ο. (2013) «Polyamine derivatives of chloramphenicol as antibacterial drugs and tools in studying the function of the ribosomal catalytic center», Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.
  9. Kournoutou G. «Structural and functional changes in the protein synthesizing machinery of Mytilus galloprovincialis experimentally exposed to toxic metals», Post-Graduate Programme on Basic Medicinal Sciences, School of Medicine, University of Patras.

Other Activities

President of the Institute Committee for granting the Basic Research and Post-Doctoral activities in University of Patras.
National Representative in the International Committee SCOAP3 for the promotion of the OPEN ACCESS to the literature.