|Sector:||Division of Basic Medical Sciences II|
|Knowledge Subject:||Neurosciences - Neurophysiology|
|Research Area:||Physiology of sleep, experimental epileptology, synaptic plasticity, electroencephalography, magnetoencephalography|
|Address:||Department of Physiology, Medical School, University of Patras, Panepistemioupolis, 26500 Greece|
|Office:||Basic Medical Sciences building, 2nd floor, west wing, B7|
George Kostopoulos son of Costas and Penelope was born in Athens in 1949 and is married with two daughters. He received his MD from the University of Athens (1972) and his PhD (Physiology) from the University of Saskatchewan, Canada (1977). He taught at McGill University, Canada as full time assistant professor with the departments of Physiology, Neurology and Neurosurgery (1978-1982) and as visiting professor of Physiology (1987-1988). Since 1982 he works at the University of Patras - since 1991 as full professor and since 2005 as chairman of the Department of Physiology of the Medical School.
He currently teaches several undergraduate and graduate courses of Physiology - mostly Neurophysiology and Neuroinformatics - and he has supervised 9 PHD Theses.
He has received research training in basic neurophysiology by John W Phillis and in EEG and experimental epileptology by Pierre Gloor. He has been using methods of in vivo and in vitro electrophysiology in experimental animals and human studies. His research interests gradually shifted from the level of single neuron excitability and synaptic transmission to that of thalamocortical and hippocampal circuits plasticity and finally to that of sleep physiology and epileptology research (in 1983 he received the Michael Price for Epileptology). His lab's research is currently supported by the project FP7-ICT-2011-7, 2011-2014 http://cordis.europa.eu/projects/rcn/101414_en.html
. He has published 88 original research articles (3.400 citations, H-index=34), as well as lecture notes, Physiology textbooks translations and articles for public awareness. Finally he has edited or contributed chapters (23) to scientific books.
Contribution to the following graduate studies programs (GSP) and courses:
GSP "Basic Medical Sciences": Neurosciences I and II, Bioethics I and II, Methodology, Research Subjects,
Interschool GSP "Informatics for Life Sciences": Principles of Human Physiology, Neurosciences, Introduction to Neuroinformatics, Neuroinfomatics I and II
Interuniversity GSPs "Biomedical Engineering" and "Medical Physics":Principles of Physiology and Pathophysiology.
| Read all the publications|
B1- Avoli, M., Gloor, P., Kostopoulos, G. and Naquet, R. (Eds.), "Generalized Epilepsy : Neurobiological Approaches", Birkhauser, Boston, 1990, pp480.
85. Kokkinos V, Koupparis AM and Kostopoulos GK. An intra-K-complex oscillation with independent and labile frequency and topography in NREM sleep. Front. Hum. Neurosci. 2013; vol. 7; article:163, pages1-16
B2- Kostopoulos G. Brain Mechanisms Linking Epilepsy to Sleep. In P. Schwartzkroin (Ed.), Encyclopedia of Basic Epilepsy Research. 2009, London: Elsevier, Vol 3. Oxford: Academic Press; 2009. pp. 1327-1336.
3 Kostopoulos, G.K., Limacher, J.J. and Phillis, J.W., Action of various adenine derivatives on cerebellar Purkinje cells, Brain Research, 88 (1975) 162-165.
13 Phillis, J.W., Edstrom, J.P., Kostopoulos, G. and Kirkratrick, J., Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex, Can. J. Physiology and Pharmacology, 57 (1979) 1289-1312.
15 Kostopoulos, G.K., Gloor, P., Pelegrini, A. and Gotman, J., A study of the transition from spindles to spike and wave discharges in feline generalized penicillin epilepsy. II. Microphysiological features, Experimental Neurology, 73 (1981) 55-77.
31 Kostopoulos, G., Drapeau, C., Avoli, M., Olivier, A. and Villemeure, J.G., Endogenous adenosine can reduce epileptiform activity in the human epileptogenic cortex maintained in vitro, Neurosci. Lett., 106(1-2) (1989) 119-124.
41 Kostopoulos, G.K. and Psarropoulou, C.T., Possible mechanisms underlying hyperexcitability in the epileptic mutant mouse tottering, Journal of Neural Transmission, 35 (1992) 109-124.
57. Kostopoulos GK Involvement of the thalamocortical system in epileptic loss of consciousness”, 2001, Epilepsia 42 (s3), 13-19.
59. Ioannides AA, Kostopoulos GK, Laskaris NA, Liu L, Shibata T, Schellens M, Poghosyan V and Khurshudyan A Timing and connectivity in the human somatosensory cortex from single trial mass electrical activity. Human Brain Mapping, 2002;15(4):231-46
60. Papatheodoropoulos C. and Kostopoulos G. Spontaneous low frequency (~ 2-3 Hz) field activity generated in rat ventral hippocampal slices perfused with normal medium. Brain Research Bulletin 2002; 57(2):187-193.
61. Papatheodoropoulos C, Asprodini E, Nikita I, Koutsona C and Kostopoulos G, Weaker synaptic inhibition in CA1 region of ventral compared to dorsal rat hippocampal slices, Brain Research, 2002, 948(1-2):117-21.
65. Ioannides AA, Corsi-Cabrera M, Fenwick P, del Rio Portilla Y, Laskaris N, Khurshudyan A, Theofilou D, Shibata T, Uchida S, Nakabayashi T and Kostopoulos GK. MEG tomography of human cortex and brainstem activity in waking and REM sleep saccades. Cerebral Cortex, 2004;14(1):56-72.
69. Papatheodoropoulos C, Moshovos C. and Kostopoulos GK , Greater contribution of NMDA receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity. Neuroscience, 2005, 135(3): 765-779.
76. Ioannides A., Kostopoulos GK, Liu L., Fenwick PB, MEG Identifies Dorsal Medial Brain Activations during Sleep. Neuroimage, 2009, vol. 44(2): 455-468.77.
79. Kokkinos V and Kostopoulos GK Human NREM stage II sleep spindles are blocked upon spontaneous K-complex coincidence and resume as higher frequency spindles afterwards. J. of Sleep Research 2011; 20: 57-72.
82. Koutroumanidis M, Tsiptsios D, Kokkinos V, Kostopoulos GK. Focal and generalized EEG paroxysms in childhood absence epilepsy: Topographic associations and distinctive behaviors during the first cycle of non-REM sleep. Epilepsia, 2012, 53(5): 840-849
|• "Long term multimodal monitoringofepilepticpatients at home: The experienceof FP7-ICT project ARMOR (2011-2014)", MICHAEL FORUM, October 9th-12th, 2014, Bonn, Germany.
• "EEG and MEG Dynamics of Sound and Safe Sleep" 19th International Conference on Biomagnetism, August 24-28, 2014, Halifax, Canada.
• «Pierre Gloor: Epilepsy is a network disease”.Special Symposium: The pioneers at the Montreal Neurological Institute: early concepts in today’s practice. 30th International Epilepsy Congress, Montreal, 23-27 June 2013.
“Neural correlates of losing consciousness in sleep and epilepsy” Albert Einstein College of Medicine, New York, 25 April 2013.
“EEG and MEG studies indicating cognitive processes during sleep”, Universite de Montreal, Dep de Psychologie, 11 April 2013l
“Glimpses into consciousness from the ways we lose it”. Montreal Neurological Institute, Brain Imaging Center and Cognitive Neuroscience group, McGill University, Canada, 25 March 2013
“Understanding sleep mechanisms contributes to a redefinition of the term “generalized” of absence seizures.” Michael Stiftung for Epileptology, 50th Anniversary Berlin October 5-6, 2012
• "Sleep's macro-, micro- and dynamic structure", "Society for Applied Neuroscience" meeting, Thessaloniki, Greece, May 2011
• "Recent Advances in Sleep Physiology of Interest to Psychoanalysis", International Federation of Psychoanalytic Societies, Athens, Oct. 2010
• "Frontal lobe and epileptic seizures: Basic mechanisms". Teaching section, Also "Presidents welcome address" at the 9th European Congress of Epileptology, Rhodes June 2010.
• "Why do we sleep?" in the frame of "Searching for the Equation. Mind, Brain and Behavior" a 3-days public awareness event organized at the Pantion University, Athens by the Center of Society, Science and Art www.caid.gr
, February 2010
• "Mechanisms underlying loss of consciousness in sleep and epilepsy" in the frame of the "Consciousness and its measures" Limasol, Cyprus, November 2009
• Dynamics of brain rhythmogenesis in human sleep and their possible contribution to epilepsy” Plenary lecture at the 8th National Neuroscience Congress, Bolu, Turkey, Apr 2009.
• “Of Brain Rhythms and Greek Arrhythmias” 18.11.2008 Society for Neuroscience Washington DC USA 18.11.2009. Satellite Events: Greek Neuroscience Social.
• “Use of animal models for AED development” 03.08.2008. Venice International University – International School of Neurological Sciences of Venice Advanced International Course: Bridging Basic with Clinical Epileptology-3. Sponsored by European Community, Eurepa, ILAE, FENS and Fondazione Istituto Neurologico C.Besta.
• «Neuronal Assemblies Supporting Brain Rhythm Transformations in Sleep and Epilepsy”. 27.06.2008. AREADNE 2008: Research in Encoding and Decoding of Neural Ensembles. Santorini, Greece.
• «Introduction to Idiopathic Generalized Epilepsy Models” 3-6.10.2007 IGR:Developmental Aspects, Bridging Basic Sciences and Clinical Research. EPAM. Antalya, Turkey.
• 1st European Congress of the International Neuropsychiatric Association and 2nd Mediterranean Congress of the World Federation of Societies of Biological Psychiatry 7-10 December 2006 Athens, “The Neurophysiologist’s View Point” on “The Imaging of the Brain Functions”
• Federation of European Physiological Societies, March 26-29, 2006, Munich. “Functional differentiation along the longitudinal axis of hippocampus and its relationship to epileptogenesis”.
• “Brain, Mind and Culture: A neuroscience debate of 2,500-year-old riddles” held in Limassol, Cyprus on 29 November - 3 December, 2004: "Epilepsy and other daemons in the brain: a historical perspective".
• “5th Ιnternational Congress of Neuropsychiatry International Neuropsychiatric Association & 1st Mediterranean Regional Congress of the World Federation of Societies of Biological Psychiatry” held on 14-18 October 2004 in Athens, Greece, I organized and chaired together with AA Ioannides the symposium "Magnetoencephalography in Psychiatry" and I gave a talk on « Magnetic Field Tomography studies during sleep and dreaming: relevance to Psychiatry».
• 7th “International Michael Forum on Epileptology” I talked on “Functional differentiation along the longitudinal axis of hippocampus and its possible relevance to epileptogenesis”, Berlin, 29 May 2004.
• 2nd International Multidisciplinary Delphi Conference «Ecological Dynamics And Human Nature. The Risk Of A Mass Extinction Of Life On The Planet», "Brain Mechanisms Of Logos And Pathos" Delphi – Greece, September 5-8, 2002.
• Annual Conference of National Epilepsy Society of Turkey, Trabzon: "Neuronal mechansims underlying absence seizures", June 9, 2002..
• 6th “International Michael Forum on Epileptology” I talked on: “Functional Differentiation Along The Longitudinal Axis Of Hippocampus: Plasticity And Epilepsy” Hamburg, Germany, 23 June 2001.
• 2nd Symposium “Sleep and Epilepsy – Physiopathological and Clinical Aspects”, Udine, Italy, May 27-29 1999.
1. Caterina Psarropoulou - 1990,
2. George Antoniades – 1995,
3. Costas Papatheodoropoulos – 1996,
4. Alexandra Badea - 2003.
5. Ovidiu Zainea - 2005,
6. Panagiotis Georgopoulos - 2008
8. Ioanna Nikita - 2009
9. Vasileios Kokkinos - 2010
- President of the "Hellenic Society for Neuroscience" (1986-1987) www.hsfn.gr
- Member of the Governing Council of the “International Brain Research Organization” (IBRO, www.ibro.org, 1990-1997), member of IBRO publication Committee (1995-today) and of IBRO Science Advisory Program (2004–today).
- Associate Editor: "Epileptologia" (2010-today); Member, Editorial Board of “Brain Research Bulletin” (1999-2011) and "Dataset Papers in Neuroscience"(2012-today).
- Contribution to efforts to educate the general public on recent developments of brain research (lately as elected member of the European DANA Alliance for the Brain) aiming to the eradication of the social stigma of certain neuropsychiatric disorders, the elucidation of ethical and social consequences of developments in neuroscience and public control of their applications. Some of these contributions can be found at: http://physiology.med.upatras.gr/NU/index.php?option=com_content&view=article&id=10&Itemid=17#d